Recombinant Human ANPEP protein, GST-tagged

• Cat.No.: ANPEP-622H
• Product Overview: Human ANPEP full-length ORF ( NP_001141.1, 1 a.a. - 967 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 135.9 kDa
• AA Sequence: MAKGFYISKSLGILGILLGVAAVCT IIALSVVYSQEKNKNANSSPVASTT PSASATTNPASATTLDQSKAWNRYR LPNTLKPDSYQVTLRPYLTPNDRGL YVFKGSSTVRFTCKEATDVIIIHSK KLNYTLSQGHRVVLRGVGGSQPPDI DKTELVEPTEYLVVHLKGSLVKDSQ YEMDSEFEGELADDLAGFYRSEYME GNVRKVVATTQMQAADARKSFPCFD EPAMKAEFNITLIHPKDLTALSNML PKGPSTPLPEDPNWNVTEFHTTPKM STYLLAFIVSEFDYVEKQASNGVLI RIWARPSAIAAGHGDYALNVTGPIL NFFAGHYDTPYPLPKSDQIGLPDFN AGAMENWGLVTYRENSLLFDPLSSS SSNKERVVTVIAHELAHQWFGNLVT IEWWNDLWLNEGFASYVEYLGADYA EPTWNLKDLMVLNDVYRVMAVDALA SSHPLSTPASEINTPAQISELFDAI SYSKGASVLRMLSSFLSEDVFKQGL ASYLHTFAYQNTIYLNLWDHLQEAV NNRSIQLPTTVRDIMNRWTLQMGFP VITVDTSTGTLSQEHFLLDPDSNVT RPSEFNYVWIVPITSIRDGRQQQDY WLIDVRAQNDLFSTSGNEWVLLNLN VTGYYRVNYDEENWRKIQTQLQRDH SAIPVINRAQIINDAFNLASAHKVP VTLALNNTLFLIEERQYMPWEAALS SLSYFKLMFDRSEVYGPMKNYLKKQ VTPLFIHFRNNTNNWREIPENLMDQ YSEVNAISTACSNGVPECEEMVSGL FKQWMENPNNNPIHPNLRSTVYCNA IAQGGEEEWDFAWEQFRNATLVNEA DKLRAALACSKELWILNRYLSYTLN PDLIRKQDATSTIISITNNVIGQGL VWDFVQSNWKKLFNDYGGGSFSFSN LIQAVTRRFSTEYELQQLEQFKKDN EETGFGSGTRALEQALEKTKANIKW VKENKEVVLQWFTENSK
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ANPEP alanyl (membrane) aminopeptidase [ Homo sapiens ]
• Official Symbol: ANPEP
• Synonyms: ANPEP; alanyl (membrane) aminopeptidase; CD13, PEPN; aminopeptidase N; aminopeptidase M; gp150; LAP1; microsomal aminopeptidase; p150; AP-M; AP-N; hAPN; alanyl aminopeptidase; myeloid plasma membrane glycoprotein CD13; APN; CD13; P150; PEPN; GP150
• Gene ID: 290
• mRNA Refseq: NM_001150
• Protein Refseq: NP_001141
• MIM: 151530
• UniProt ID: P15144