Recombinant Human ANTXR1 protein, GST-tagged

• Cat.No.: ANTXR1-625H
• Product Overview: Human ANTXR1 full-length ORF ( NP_444262.1, 1 a.a. - 368 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 67.6 kDa
• AA Sequence: MATAERRALGIGFQWLSLATLVLIC AGQGGRREDGGPACYGGFDLYFILD KSGSVLHHWNEIYYFVEQLAHKFIS PQLRMSFIVFSTRGTTLMKLTEDRE QIRQGLEELQKVLPGGDTYMHEGFE RASEQIYYENRQGYRTASVIIALTD GELHEDLFFYSEREANRSRDLGAIV YCVGVKDFNETQLARIADSKDHVFP VNDGFQALQGIIHSILKKSCIEILA AEPSTICAGESFQVVVRGNGFRHAR NVDRVLCSFKINDSVTLNEKPFSVE DTYLLCPAPILKEVGMKAALQVSMN DGLSFISSSVIITTTHCSDGSILAI ALLILFLLLALALLWWFWPLCCTVI IKEVPPPPAEESEENKIK
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ANTXR1 anthrax toxin receptor 1 [ Homo sapiens ]
• Official Symbol: ANTXR1
• Synonyms: ANTXR1; anthrax toxin receptor 1; anthrax toxin receptor; ATR; FLJ10601; FLJ21776; TEM8; tumor endothelial marker 8 precursor; 2310008J16Rik; 2810405N18Rik; tumor endothelial marker 8; FLJ11298
• Gene ID: 84168
• mRNA Refseq: NM_018153
• Protein Refseq: NP_060623
• MIM: 606410
• UniProt ID: Q9H6X2