Recombinant Human AP3S2 Protein, His-tagged

• Cat.No.: AP3S2-193H
• Product Overview: Recombinant Human AP3S2 Protein (Met1-Val193) with N-His tag was expressed in E. coli.

Specification

• Description: Predicted to be involved in anterograde synaptic vesicle transport and vesicle-mediated transport. Located in intracellular membrane-bounded organelle. Part of AP-3 adaptor complex.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 25.7 kDa
  Accurate Molecular Mass: 24 kDa
• Protein length: Met1-Val193
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1 mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: AP3S2 adaptor-related protein complex 3, sigma 2 subunit [ Homo sapiens (human) ]
• Official Symbol: AP3S2
• Synonyms: AP3S2; adaptor-related protein complex 3, sigma 2 subunit; AP-3 complex subunit sigma-2; sigma3b; sigma-3B-adaptin; sigma-adaptin 3b; adaptor complex sigma3B; AP-3 complex subunit sigma-3B; clathrin-associated/assembly/adaptor protein, small 4, 22-kD; AP3S3; FLJ35955
• Gene ID: 10239
• mRNA Refseq: NM_005829
• Protein Refseq: NP_005820
• MIM: 602416
• UniProt ID: P59780

Reviews

11/11/2020

Green production process of AP3S2 is very advanced, using the most environmentally friendly production process and is very friendly to the environment.

09/11/2020

They have a wide range of products and can always find the AP3S2 we need.

09/02/2020

Catalytic activity of AP3S2 is really amazing, and it can bring unexpected catalytic effects every time it is used, and its performance is impressive.

08/10/2020

The reproducibility of AP3S2 can be said to be almost 100 percent, and the results are very consistent in every experiment or application, which is an important indication of its excellent quality.

Q&As

In addition to cancer treatment, what other areas can AP3S2 be used?

AP3S2 can also be used in the treatment of inflammation, autoimmune diseases and other fields.

What are the physicochemical properties of AP3S2 ?

The AP3S2 has a relative molecular mass of about 16-18KDa and an isoelectric point of about 5.5-6.0.

What are the structural characteristics of AP3S2 ?

The AP3S2 belongs to the small G protein family and has the structure of GTPase activity, which is similar to other small G proteins in terms of molecular structure.

What are the possible future application prospects of AP3S2 ?

With the continuous research and in-depth understanding of the mechanism of action of AP3S2 , its future treatment prospects in tumor, inflammation and other fields are broad.

Can AP3S2 be used in clinical treatment?

At present, there are no reports and studies on the application of AP3S2 in clinical treatment.

Which diseases is the of AP3S2 valuable for research and treatment?

At present, the therapeutic value of recombinant AP3S2 protein is mainly concentrated in the fields of tumor and inflammation.

Why was recombinant AP3S2 chosen for cancer treatment?

AP3S2 is involved in intracellular protein transport, which can directly affect the growth and proliferation of cancer cells. It can also promote the immune system to clear cancer cells.

Can the combination of AP3S2 and other therapeutic agents have a better therapeutic effect?

The combination of AP3S2 and other therapeutic agents can have a better therapeutic effect, but the specific effect needs to be further studied.

What are the best storage conditions for AP3S2 ?

The optimal storage condition of AP3S2 is the refrigerator at -20℃, avoid light and moisturize, and do not repeatedly freeze and thaw.

What is the relationship between AP3S2 and immune system?

Recombinant AP3S2 protein is involved in intracellular immune regulation and can affect the tubule system, cytophagocytosis and the formation of acidic lysosomes.

What is the biological function of AP3S2 ?

The AP3S2 is involved in protein transport from the Golgi apparatus to the endoplasmic reticulum during intracellular transport.

What is the clinical manifestation of recombinant AP3S2 in mouse models?

Recombinant AP3S2 protein in mouse model can significantly promote tumor growth inhibition and reduce tumor metastasis.

What is the cost of synthesizing AP3S2 ?

The cost of synthesis of AP3S2 varies according to different manufacturers, methods and other factors.

What is the progress of preclinical research on AP3S2 ?

At present, the preclinical research of AP3S2 mainly focuses on in vivo and in vitro experiments and animal model studies.

What is the synthesis method of AP3S2 ?

AP3S2 can be prepared by synthesis, expression and purification.

How difficult is the preparation of AP3S2 ?

The preparation difficulty of AP3S2 depends on the specific preparation method and experimental conditions.