|Product Overview :
||Human APEX1 full-length ORF ( AAH02338, 1 a.a. - 318 a.a.) recombinant protein with GST-tag at N-terminal.
||Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008]
|Molecular Mass :
|AA Sequence :
||Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
||Best use within three months from the date of receipt of this protein.
||Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
|Storage Buffer :
||50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
12.5% SDS-PAGE Stained with Coomassie Blue.