Recombinant Human APOL3 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : APOL3-472H
Product Overview : APOL3 MS Standard C13 and N15-labeled recombinant protein (NP_663614) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : This gene is a member of the apolipoprotein L gene family, and it is present in a cluster with other family members on chromosome 22. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids, including cholesterol, and/or allow the binding of lipids to organelles. In addition, expression of this gene is up-regulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Alternative splicing results in multiple transcript variants.
Source : HEK293
Species : Human
Tag : Myc&DDK
Molecular Mass : 36.5 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : APOL3 apolipoprotein L3 [ Homo sapiens (human) ]
Official Symbol : APOL3
Synonyms : APOL3; apolipoprotein L, 3; apolipoprotein L3; APOLIII; CG12 1; CG12_1; apoL-III; apolipoprotein L-III; TNF-inducible protein CG12-1; CG121;
Gene ID : 80833
mRNA Refseq : NM_145639
Protein Refseq : NP_663614
MIM : 607253
UniProt ID : O95236

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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    They can offer insights into interpreting results and assist in identifying trends or patterns that may be relevant to the specific research question.


      The manufacturer's technical support can also aid researchers in the data analysis phase.


        They can provide valuable guidance in experimental design, optimization, and troubleshooting, helping researchers overcome challenges and maximize the efficiency of their trials.


          the manufacturer's technical support is instrumental in assisting researchers throughout their trials.

          Q&As (9)

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          How is APOL3 expression regulated? 10/30/2022

          The regulatory mechanisms governing APOL3 expression are not well characterized. However, studies have shown that APOL3 expression can be influenced by genetic and environmental factors, hormonal factors, and inflammatory stimuli. Further investigations are required to elucidate the precise mechanisms involved in the regulation of APOL3 expression.

          Are there any specific tissues where APOL3 protein is predominantly expressed? 12/30/2021

          APOL3 is primarily expressed in the liver, which is a major site of lipid metabolism. However, it is also found in other tissues such as the intestines, kidney, and adipose tissue, albeit at lower levels.

          Are there any known interacting partners of APOL3? 10/22/2020

          The exact interacting partners of APOL3 are not extensively characterized. However, APOL3 is known to interact with other apolipoproteins, such as apolipoprotein A1 (APOA1), as part of the HDL complex. These interactions contribute to the role of APOL3 in lipid metabolism and transport.

          Are there any known disorders or conditions associated with APOL3 mutations? 05/10/2020

          Specific pathological conditions directly linked to APOL3 mutations have not been extensively reported. However, variations in the APOL3 gene have been associated with dyslipidemia, altered lipid profiles, and an increased risk of cardiovascular diseases, as mentioned earlier.

          Is there any known genetic variation in the APOL3 gene? 08/11/2019

          Yes, genetic variations have been identified in the APOL3 gene. These include single nucleotide polymorphisms (SNPs) that can lead to changes in the protein structure or function. Some of these SNPs have been associated with altered lipid levels and increased risk for cardiovascular diseases.

          Can targeting APOL3 be a potential therapeutic strategy? 06/24/2018

          The therapeutic potential of targeting APOL3 is currently unclear. It may have implications for lipid disorders and cardiovascular diseases, but more research is needed to determine whether modulating APOL3 levels or function could be a viable therapeutic approach.

          Is there any ongoing research exploring the functions of APOL3? 03/29/2018

          Yes, ongoing research aims to further unravel the functions and mechanisms of APOL3. Scientists are investigating its role in lipid metabolism, atherosclerosis development, and potential therapeutic targeting. Additionally, studies are being conducted to explore the broader physiological functions of APOL3 in various biological processes and disease contexts.

          Does APOL3 have any disease implications? 08/07/2017

          Previous research has suggested that genetic variations in the APOL3 gene may be associated with an increased risk of cardiovascular diseases, including atherosclerosis and coronary artery disease. However, further studies are needed to fully understand the exact role of APOL3 in these conditions.

          Does APOL3 have any other physiological functions besides lipid metabolism? 04/10/2017

          While the primary function of APOL3 is related to lipid metabolism, recent studies have suggested its involvement in additional processes. For instance, APOL3 has been implicated in modulating immune responses and regulating the growth and differentiation of certain cell types, indicating potential roles beyond lipid metabolism.

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