Recombinant Human ARSL Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : ARSL-441H
Product Overview : ARSE MS Standard C13 and N15-labeled recombinant protein (NP_000038) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : Arylsulfatase E is a member of the sulfatase family. It is glycosylated postranslationally and localized to the golgi apparatus. Sulfatases are essential for the correct composition of bone and cartilage matrix. X-linked chondrodysplasia punctata, a disease characterized by abnormalities in cartilage and bone development, has been linked to mutations in this gene. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the Y chromosome.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 65.7 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : ARSL arylsulfatase L [ Homo sapiens (human) ]
Official Symbol : ARSL
Synonyms : ARSL; arylsulfatase L; ASE; ARSE; CDPX; CDPX1; CDPXR; arylsulfatase L; arylsulfatase E (chondrodysplasia punctata 1); EC
Gene ID : 415
mRNA Refseq : NM_000047
Protein Refseq : NP_000038
MIM : 300180
UniProt ID : P51690

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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Q&As (11)

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Can mutations in the ARSL gene lead to any developmental abnormalities? 03/09/2023

Currently, there is no documented evidence linking ARSL gene mutations to developmental abnormalities. However, since the ARSL protein is involved in important metabolic processes, it is possible that severe disruptions in its function could have developmental consequences.

Can variations in the ARSL gene affect drug metabolism or response? 03/30/2022

While no direct links between ARSL gene variations and drug metabolism or response have been reported, disturbances in sulfated compound metabolism, which ARSL participates in, can indirectly influence drug pharmacokinetics and efficacy. Further research is needed to fully understand these relationships.

What tissues express the ARSL protein? 11/24/2021

The ARSL protein is widely expressed in various tissues, including the liver, kidney, brain, and intestines, among others. Its expression pattern reflects its involvement in the metabolism of sulfated compounds throughout the body.

Are there any known diseases associated with ARSL protein mutations? 06/16/2021

Currently, there are no known diseases specifically associated with mutations in the ARSL gene. However, dysregulation or deficiency of ARSL activity may contribute to certain disorders that involve impaired sulfated compound metabolism.

Does the expression of the ARSL protein change under different physiological conditions? 04/19/2021

The expression of the ARSL protein can vary depending on the tissue type, developmental stage, and specific physiological conditions. Research suggests that factors such as inflammation and cellular stress can influence ARSL expression levels to regulate sulfated compound metabolism.

Is there a link between ARSL protein dysfunction and neurodegenerative disorders? 09/02/2020

While currently there is no known direct link between ARSL dysfunction and neurodegenerative disorders, disturbances in sulfated compound metabolism have been implicated in some neurodegenerative diseases. Further research is necessary to determine if ARSL dysfunction contributes to these conditions.

How is the ARSL protein transported within the cell? 03/08/2019

The ARSL protein contains specific targeting sequences that facilitate its transport to the lysosomes, where it carries out its enzymatic activity. Trafficking of ARSL from the endoplasmic reticulum to the lysosomes involves interactions with various intracellular transport machinery.

Can the ARSL protein be targeted for therapeutic interventions? 08/06/2017

While the therapeutic targeting of the ARSL protein itself is not currently explored extensively, the manipulation of its activity or related pathways may hold potential for certain diseases involving abnormal sulfated compound metabolism. Further research is needed to determine the therapeutic implications of ARSL modulation.

Is the ARSL protein found in other organisms besides humans? 03/19/2017

Yes, the ARSL protein is conserved across multiple organisms, including mammals, birds, fish, and certain invertebrates. This suggests its significance in sulfated compound metabolism is evolutionarily conserved.

How is the ARSL protein related to lysosomal storage disorders? 11/19/2016

The ARSL protein is not directly associated with lysosomal storage disorders. However, disturbances in lysosomal function, which is involved in the breakdown of sulfated compounds, can impact ARSL-mediated pathways, potentially contributing to the pathogenesis of lysosomal storage disorders.

Are there any known modulators or inhibitors of the ARSL protein? 06/06/2016

Currently, specific modulators or inhibitors of the ARSL protein have not been reported. However, it is possible that compounds or molecules affecting sulfated compound metabolism or lysosomal function could indirectly alter the activity of ARSL.

Customer Reviews (3)

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    Its versatility and consistent performance make it an indispensable tool for a wide range of research applications.


      Whether it's protein quantification, structural analysis, or Western Blotting, the ARSL protein has consistently delivered exceptional results, earning my highest recommendation.


        The ARSL protein has proven invaluable in protein electron microscopy structure analysis, allowing for detailed investigations and providing critical insights.

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