| Description : |
This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
77.8 kDa |
| AA Sequence : |
MAAATGDPGLSKLQFAPFSSALDVG FWHELTQKKLNEYRLDEAPKDIKGY YYNGDSAGLPARLTLEFSAFDMSAP TPARCCPAIGTLYNTNTLESFKTAD KKLLLEQAANEIWESIKSGTALENP VLLNKFLLLTFADLKKYHFYYWFCY PALCLPESLPLIQGPVGLDQRFSLK QIEALECAYDNLCQTEGVTALPYFL IKYDENMVLVSLLKHYSDFFQGQRT KITIGVYDPCNLAQYPGWPLRNFLV LAAHRWSSSFQSVEVVCFRDRTMQG ARDVAHSIIFEVKLPEMAFSPDCPK AVGWEKNQKGGMGPRMVNLSECMDP KRLAESSVDLNLKLMCWRLVPTLDL DKVVSVKCLLLGAGTLGCNVARTLM GWGVRHITFVDNAKISYSNPVRQPL YEFEDCLGGGKPKALAAADRLQKIF PGVNARGFNMSIPMPGHPVNFSSVT LEQARRDVEQLEQLIESHDVVFLLM DTRESRWLPAVIAASKRKLVINAAL GFDTFVVMRHGLKKPKQQGAGDLCP NHPVASADLLGSSLFANIPGYKLGC YFCNDVVAPGDSTRDRTLDQQCTVS RPGLAVIAGALAVELMVSVLQHPEG GYAIASSSDDRMNEPPTSLGLVPHQ IRGFLSRFDNVLPVSLAFDKCTACS SKVLDQYEREGFNFLAKVFNSSHSF LEDLTGLTLLHQETQAAEIWDMSDD ETITRTRPLEQKLISEEDLAANDIL DYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
