Recombinant Human AURKA protein, GST-tagged

• Cat.No.: AURKA-1037H
• Product Overview: Human AURKA full-length ORF ( AAH01280, 1 a.a. - 403 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 70.07 kDa
• AA Sequence: MDRSKENCISGPVKATAPVGGPKRV LVTQQFPCQNPLPVNSGQAQRVLCP SNSSQRVPLQAQKLVSSHKPVQNQK QKQLQATSVPHPVSRPLNNTQKSKQ PLPSAPENNPEEELASKQKNEESKK RQWALEDFEIGRPLGKGKFGNVYLA REKQSKFILALKVLFKAQLEKAGVE HQLRREVEIQSHLRHPIILRLYGYF HDATRVYLILEYAPLGTVYRELQKL SKFDEQRTATYITELANALSYCHSK RVIHRDIKPENLLLGSAGELKIADF GWSVHAPSSRRTTLCGTLDYLPPEM IEGRMHDEKVDLWSLGVLCYEFLVG KPPFEANTYQETYKRISRVEFTFPD FVTEGARDLISRLLKHNPSQRPMLR EVLEHPWITANSSKPSNCQNKESAS KQS
• Applications: Kinase Assay; Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: AURKA aurora kinase A [ Homo sapiens ]
• Official Symbol: AURKA
• Synonyms: AURKA; aurora kinase A; serine/threonine kinase 6 , serine/threonine kinase 15 , STK6, STK15; ARK1; AurA; BTAK; PPP1R47; protein phosphatase 1; regulatory subunit 47; STK7; ARK-1; hARK1; aurora 2; IPL1-related kinase; aurora-related kinase 1; aurora/IPL1-like kinase; serine/threonine kinase 6; aurora/IPL1-related kinase 1; breast tumor-amplified kinase; breast-tumor-amplified kinase; serine/threonine-protein kinase 6; serine/threonine protein kinase 15; serine/threonine-protein kinase 15; serine/threonine-protein kinase aurora-A; protein phosphatase 1, regulatory subunit 47; AIK; AURA; STK6; STK15; AURORA2; MGC34538
• Gene ID: 6790
• mRNA Refseq: NM_003600
• Protein Refseq: NP_003591
• MIM: 603072
• UniProt ID: O14965