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Recombinant Human AURKB protein, GST-tagged

Cat.No. : AURKB-1038H
Product Overview : Human AURKB full-length ORF ( AAH09751.1, 1 a.a. - 344 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
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Description : This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 63.47 kDa
AA Sequence : MAQKENSYPWPYGRQTAPSGLSTLP QRVLRKEPVTPSALVLMSRSNVQPT AAPGQKVMENSSGTPDILTRHFTID DFEIGRPLGKGKFGNVYLAREKKSH FIVALKVLFKSQIEKEGVEHQLRRE IEIQAHLHHPNILRLYNYFYDRRRI YLILEYAPRGELYKELQKSCTFDEQ RTATIMEELADALMYCHGKKVIHRD IKPENLLLGLKGELKIADFGWSVHA PSLRRKTMCGTLDYLPPEMIEGRMH NEKVDLWCIGVLCYELLVGNPPFES ASHNETYRRIVKVDLKFPASVPMGA QDLISKLLRHNPSERLPLAQVSAHP WVRANSRRVLPPSALQSVA
Applications : Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : AURKB aurora kinase B [ Homo sapiens ]
Official Symbol : AURKB
Synonyms : AURKB; aurora kinase B; serine/threonine kinase 12 , STK12; Aik2; AIM 1; ARK2; AurB; aurora 1; aurora B; IPL1; PPP1R48; protein phosphatase 1; regulatory subunit 48; STK5; ARK-2; STK-1; aurora-1; aurora-B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora-related kinase 2; serine/threonine kinase 12; aurora/IPL1-related kinase 2; serine/threonine-protein kinase 5; serine/threonine-protein kinase 12; serine/threonine-protein kinase aurora-B; protein phosphatase 1, regulatory subunit 48; aurora- and Ipl1-like midbody-associated protein 1; AIK2; AIM1; AIM-1; STK12; aurkb-sv1; aurkb-sv2;
Gene ID : 9212
mRNA Refseq : NM_001256834
Protein Refseq : NP_001243763
MIM : 604970
UniProt ID : Q96GD4

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What are the interactions between AURKB protein and cell cycle regulatory proteins? 12/03/2022

AURKB protein interacts with a variety of cell cycle regulatory proteins, including Cdk1, INCENP, Survivin, etc., to regulate the progression of cell mitosis.

What are the intracellular substrates of AURKB protein? 09/09/2022

The substrates of AURKB include chromosome-associated proteins, cytoskeletal proteins and other cell cycle regulatory proteins. Phosphorylation modification of these substrates regulates chromosome segregation and cell division during mitosis.

What is the cellular localization of AURKB protein? 06/30/2021

AURKB protein is mainly located in the nucleus and cytoplasm and participates in the regulation of cell mitosis.

What is the expression pattern of AURKB gene? 08/11/2020

The expression of the AURKB gene is regulated by cell cycle regulators and other transcription factors and is mainly expressed in the mitotic phase of cells.

How does AURKB protein activity work? 03/14/2020

The activity of AURKB protein is regulated by a variety of factors, including phosphorylation modification, protein interaction and cell cycle regulation.

At what stage of cell mitosis does AURKB protein reach its peak expression? 04/08/2019

The protein reaches its peak expression during early and metaphase of cell mitosis and is closely associated with chromosome segregation and cell division.

Customer Reviews (3)

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Reviews
12/28/2021

    AURKB's exceptional repeatability allows for its reliable use in a range of applications, making it a top choice for researchers.

    08/31/2021

      Very pure and can be used with confidence.

      02/03/2019

        The quality is very high and very reliable.

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