Recombinant Human B4GALT3 Protein, His-tagged

• Cat.No.: B4GALT3-315H
• Product Overview: Recombinant Human B4GALT3, transcript variant 2, fused with His tag at C-terminal was expressed in HEK293 cells.

Specification

• Description: This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene encodes an enzyme that may be mainly involved in the synthesis of the first N-acetyllactosamine unit of poly-N-acetyllactosamine chains. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
• Source: HEK293 cells
• Tag: His
• Form: Supplied as a 0.2 µM filtered solution of 20mM TrisHCl, 150mM NaCl, 2mM MgCl2, 10%Glycerol, pH7.5
• Molecular Mass: 41.5kD
• AA Sequence: RSLSALFGRDQGPTFDYSHPRDVYS NLSHLPGAPGGPPAPQGLPYCPERS PLLVGPVSVSFSPVPSLAEIVERNP RVEPGGRYRPAGCEPRSRTAIIVPH RAREHHLRLLLYHLHPFLQRQQLAY GIYVIHQAGNGTFNRAKLLNVGVRE ALRDEEWDCLFLHDVDLLPENDHNL YVCDPRGPRHVAVAMNKFGYSLPYP QYFGGVSALTPDQYLKMNGFPNEYW GWGGEDDDIATRVRLAGMKISRPPT SVGHYKMVKHRGDKGNEENPHRFDL LVRTQNSWTQDGMNSLTYQLLAREL GPLYTNITADIGTDPRGPRAPSGPR YPPGSSQAFRQEMLQRRPPARPGPL STANHTALRGSHVDHHHHHH*
• Endotoxin: Endotoxin level is <0.1 ng/µg of protein (<1EU/µg).
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining

Gene Information

• Gene Name: B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 [ Homo sapiens ]
• Official Symbol: B4GALT3
• Synonyms: B4GALT3; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3; beta-1,4-galactosyltransferase 3; beta4Gal T3; b4Gal-T3; beta-1,4-GalTase 3; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3; beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase 3; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3; beta4Gal-T3
• Gene ID: 8703
• mRNA Refseq: NM_001199873
• Protein Refseq: NP_001186802
• MIM: 604014
• UniProt ID: O60512