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Recombinant Human BTK Protein, MYC/DDK-tagged

Cat.No. : BTK-2827H
Product Overview : Recombinant Human BTK protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293.
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  • Gene Information
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Description : The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms.
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 76.1 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : BTK Bruton agammaglobulinemia tyrosine kinase [ Homo sapiens ]
Official Symbol : BTK
Synonyms : AGMX1; AT; ATK; BPK; IMD1; PSCTK1; XLA
Gene ID : 695
mRNA Refseq : NM_000061
Protein Refseq : NP_000052
MIM : 300300
UniProt ID : Q06187

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the current progress in drug development for BTK? 04/02/2022

The development of drugs targeting BTK is currently in the clinical trial stage, including small molecule inhibitors against BTK and inhibitors targeting BTK signaling pathways.

How can BTK be used as a biomarker in clinical practice? 12/28/2021

In clinical practice, the expression level of BTK can be detected to predict disease progression and prognosis, and to guide the choice of treatment regimen. For example, in the diagnosis and treatment of lymphoma and leukemia, testing the expression level of BTK can help doctors determine the type, stage and prognosis of the disease, and guide the choice of treatment regimen.

What is the significance of studying BTK proteins? 08/26/2021

BTK proteins can help to gain insight into the mechanisms of B cell development and activation, as well as the pathogenesis of certain diseases such as lymphoma and leukemia. In addition, it is of great significance for the development of new drugs and treatment strategies.

Does BTK protein play a role in tumor immunotherapy? 03/22/2021

BTK protein plays an important role in tumor immunotherapy, which can activate the immune response of tumor cells, promote apoptosis of tumor cells and inhibit the proliferation of tumor cells.

How is BTK protein related to viral infection? 08/01/2020

Studies have shown that BTK protein can participate in the regulation of antiviral immune responses and affect the course of viral infection.

What are the applications of BTK protein in drug discovery? 02/12/2020

It can be used as a target for the development of new drugs, or as a drug carrier for the directional delivery of drugs.

Customer Reviews (3)

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Reviews
02/08/2022

    High purity, lack of impurities, in the experiment performance is very efficient.

    02/03/2022

      Short half-life, more flexible dosage plan.

      09/12/2021

        It's stable in all kinds of environments.

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