Recombinant Human CACNB4, His-tagged

• Cat.No.: CACNB4-10640H
• Product Overview: Recombinant Human CACNB4 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-350a.a.
• Description: This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: CACNB4 calcium channel,voltage-dependent,beta 4 subunit [ Homo sapiens ]
• Official Symbol: CACNB4
• Synonyms: CACNB4;Cavβ4 Calcium Channel;EA5;EJM;calcium channel,voltage-dependent,beta 4 subunit;CAB4;EIG9;EJM4;EJM6;CACNLB4;voltage-dependent L-type calcium channel subunit beta-4;calcium channel voltage-dependent subunit beta 4;dihydropyridine-sensitive L-type,cal
• Gene ID: 785
• mRNA Refseq: NM_000726
• Protein Refseq: NP_000717
• MIM: 601949
• UniProt ID: O00305
• Chromosome Location: 2q22-q23
• Pathway: rrhythmogenic right ventricular cardiomyopathy (ARVC);Axon guidance;Cardiac muscle contraction;Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels;Developmental Biology;Dilated cardiomyopathy;Hypertrophic cardiomyopathy (HCM)
• Function: contributes_to high voltage-gated calcium channel activity;protein binding;contributes_to voltage-gated calcium channel activity;voltage-gated ion channel activity