Recombinant Human CBX1 Protein, GST-Tagged

• Cat.No.: CBX1-0477H
• Product Overview: Human CBX1 full-length ORF (NP_006798.1, 1 a.a. - 185 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 47.8 kDa
• AA Sequence: MGKKQNKKKVEEVLEEEEEEYVVEK VLDRRVVKGKVEYLLKWKGFSDEDN TWEPEENLDCPDLIAEFLQSQKTAH ETDKSEGGKRKADSDSEDKGEESKP KKKKEESEKPRGFARGLEPERIIGA TDSSGELMFLMKWKNSDEADLVPAK EANVKCPQVVISFYEERLTWHSYPS EDDDKKDDKN
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CBX1 chromobox homolog 1 [ Homo sapiens ]
• Official Symbol: CBX1
• Synonyms: CBX1; chromobox homolog 1; chromobox homolog 1 (Drosophila HP1 beta); chromobox protein homolog 1; CBX; HP1 beta homolog (Drosophila); HP1 BETA; HP1Hs beta; M31; MOD1; HP1 beta homolog; modifier 1 protein; heterochromatin protein 1-beta; heterochromatin protein p25 beta; heterochromatin protein 1 homolog beta; chromobox homolog 1 (HP1 beta homolog Drosophila); p25beta; HP1-BETA; HP1Hsbeta; HP1Hs-beta
• Gene ID: 10951
• mRNA Refseq: NM_001127228
• Protein Refseq: NP_001120700
• MIM: 604511
• UniProt ID: P83916