Recombinant Human CD44, Fc tagged

Cat.No. : CD44-421H
Product Overview : Recombinant Human CD44 (P16070-1) (Met1-Pro220), fused with the Fc region of human IgG1 at the C-terminus, was produced in Human Cells.
Availability July 19, 2024
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Source : Human Cells
Species : Human
Tag : Fc
Predicted N Terminal : Gln 21
Form : Lyophilized from sterile PBS, pH 7.4.Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization.
Molecular Mass : The recombinant human CD44/Fc is a disulfide-linked homodimer. The reduced monomer comprises 441 amino acids and has a predicted molecular mass of 49.1 kDa. The apparent molecular mass of the protein is approximately 76 kDa in SDS-PAGE under reducing cond
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : >90 % as determined by SDS-PAGE
Stability : Samples are stable for up to twelve months from date of receipt at -70oC.
Storage : Store it under sterile conditions at -20oC~-70oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : CD44 CD44 molecule (Indian blood group) [ Homo sapiens ]
Official Symbol : CD44
Gene ID : 960
mRNA Refseq : NM_000610
Protein Refseq : NP_000601
MIM : 107269
UniProt ID : P16070
Chromosome Location : 11p13

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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03/08/2022

    Using this reagent, I can gain a better understanding of the functionality and regulatory mechanisms of proteins.

    04/26/2019

      This reagent has long-lasting performance, enduring prolonged experimental use.

      03/14/2019

        A miraculous reagent driving us towards the frontiers, inviting a glance into an expanded world.

        Q&As (7)

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        What is the role of CD44 in cancer? 04/27/2023

        CD44 is implicated in cancer progression and metastasis. It promotes tumor cell invasion, migration, and adhesion to the extracellular matrix. CD44 also plays a role in cancer stem cell maintenance and drug resistance. Its overexpression is associated with poor prognosis in various types of cancer.

         Can CD44 be targeted for therapeutic purposes? 05/19/2021

        Targeting CD44 has been explored as a potential therapeutic strategy in cancer and inflammatory diseases. Strategies include blocking CD44-ligand interactions, inhibiting CD44 signaling pathways, and targeting CD44-positive cancer stem cells. However, further research is needed to fully understand the complex roles of CD44 in different disease contexts and to develop effective CD44-targeted therapies.

        How is the expression of CD44 regulated? 03/10/2021

        The expression of CD44 is regulated at multiple levels, including transcriptional control, alternative splicing, and post-translational modifications. Transcription factors such as Sp1 and NF-κB can bind to the CD44 promoter region to regulate its gene expression. Additionally, alternative splicing of CD44 pre-mRNA generates CD44 isoforms with different functions and expression patterns.

         How does CD44 contribute to immune regulation? 11/02/2019

        CD44 is involved in immune cell activation, trafficking, and homing. It participates in the recruitment of leukocytes to sites of inflammation and mediates T cell adhesion and migration. CD44 can also modulate immune responses by interacting with other immune receptors and cytokines, and it is involved in the regulation of T cell activation and differentiation.

        How is CD44 involved in immune regulation? 05/12/2019

        CD44 plays a vital role in immune regulation by participating in immune cell activation, migration, and modulation of T-cell activation and differentiation. CD44 is expressed on various immune cell populations, including T cells, B cells, natural killer cells, and dendritic cells. It serves as an adhesion molecule and facilitates immune cell trafficking to lymphoid tissues and inflammatory sites. CD44 also functions as a co-stimulatory receptor, enhancing T-cell activation and cytokine production upon interaction with its ligands. Moreover, CD44 isoforms have been implicated in the differentiation of T helper cell subsets, such as Th1, Th2, and Th17 cells. These findings highlight the multifaceted role of CD44 in immune regulation and its potential as a therapeutic target for immune-related disorders.

        What is the cellular localization of the protein CD44? 02/11/2016

        CD44 is a transmembrane glycoprotein predominantly localized on the cell surface, specifically in the plasma membrane of various cell types, including epithelial cells, leukocytes, and mesenchymal cells.

         What are the signaling pathways associated with CD44? 01/03/2016

        CD44 can activate various signaling pathways, including PI3K/AKT, MAPK/ERK, and NF-κB pathways. These pathways mediate downstream cellular processes such as cell survival, proliferation, migration, and immune responses. CD44 can also interact with other cell surface receptors, such as receptor tyrosine kinases, to modulate their signaling activities.

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