Recombinant Human CD55 Protein, His-tagged

Cat.No. : CD55-689H
Product Overview : Recombinant Human CD55 Protein (Asp35-Ser353) with His tag was expressed in 293F.
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Description : This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins.
Source : HEK293F
Species : Human
Tag : N-His
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 36.6 kDa; Accurate Molecular Mass: 58 kDa
Protein length : Asp35-Ser353
Purity : > 95%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Storage Buffer : 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Reconstitution : Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
FACS:
Gene Name : CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) [ Homo sapiens (human) ]
Official Symbol : CD55
Synonyms : CD55; CD55 molecule, decay accelerating factor for complement (Cromer blood group); DAF, decay accelerating factor for complement (CD55, Cromer blood group system); complement decay-accelerating factor; CR; CROM; TC; CD55 antigen; DAF;
Gene ID : 1604
mRNA Refseq : NM_000574
Protein Refseq : NP_000565
MIM : 125240
UniProt ID : P08174

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How do genetic variations in CD55 influence susceptibility to complement-mediated disorders, and what are the molecular mechanisms involved? 03/28/2022

Genetic variations in CD55 may influence susceptibility to complement-mediated disorders by affecting the protein's ability to regulate complement activation. This can lead to conditions like paroxysmal nocturnal hemoglobinuria (PNH).

How does CD55 contribute to the modulation of immune responses beyond its role in complement regulation? 05/22/2021

CD55 has immunomodulatory functions beyond complement regulation, influencing T cell responses and contributing to the maintenance of immune tolerance.

What role does CD55 play in protecting cells from complement-mediated lysis, and how does it contribute to immune evasion? 08/09/2019

CD55 protects cells from complement-mediated lysis by preventing the formation of membrane attack complexes. This contributes to immune evasion by pathogens and self-cells alike.

Can you elaborate on the structural domains of CD55 and how they mediate its interactions with complement components? 03/14/2018

CD55 consists of extracellular domains responsible for interactions with complement proteins, particularly C3b and C4b. These interactions prevent the formation of membrane attack complexes on host cells.

Can you discuss the involvement of CD55 in various diseases, including autoimmune disorders and infectious diseases? 01/06/2018

CD55 dysregulation is associated with autoimmune disorders, where it may contribute to immune system overactivity. Additionally, some pathogens exploit CD55 to evade host immune responses.

Customer Reviews (3)

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Reviews
02/23/2022

    Efficient shipping and exceptional product quality. This company knows how to serve its customers.

    09/20/2019

      Consistency is key in research, and this product delivers that every time.

      03/02/2018

        We've tried various proteins, but this one stands out for its purity and performance.

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