Recombinant Human CEACAM8 Protein (Gln35-Asp320), His tagged

• Cat.No.: CEACAM8-0849H
• Product Overview: Recombinant human CEACAM8 (Gln35-Asp320) fused with His tag was expressed in E. coli.

Specification

• Description: Carcinoembryonic Antigen-Related Cell Adhesion Molecule 8 (CEACAM8) is a single chain, GPI-anchored, highly glycosylated protein which belongs to the immunoglobulin superfamily and the carcinoembryonic antigen (CEA) family. CEACAM8 is expressed by neutrophils and eosinophils, and serves as a binding partner for CEACAM-6 and Galectin-3. It contains two Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. Mature human CEACAM8 is a 287 amino acid GPI-linked glycoprotein. CEACAM family members are a set of widely expressed proteins involved in several biological functions, including cell adhesion, migration, signal transduction, and the regulation of gene expression. Abnormal overexpression and downregulation of some CEACAMs have been described in tumor cells.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 32.12 kDa
• Protein length: Gln35-Asp320
• Purity: >90% as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles.
  Store at 2 to 8 centigrade for one week.
  Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 [ Homo sapiens (human) ]
• Official Symbol: CEACAM8
• Synonyms: CEACAM8; carcinoembryonic antigen-related cell adhesion molecule 8; CGM6; CD66b; CD67 antigen; carcinoembryonic antigen CGM6; non-specific cross-reacting antigen NCA-95; carcinoembryonic antigen gene family member 6; CD67; NCA-95
• Gene ID: 1088
• mRNA Refseq: NM_001816
• Protein Refseq: NP_001807
• MIM: 615747
• UniProt ID: P31997

Reviews

12/24/2021

Trusted partner. Contributes to our research discoveries.

09/09/2021

Essential for research milestones. Highly recommended service.

07/07/2017

Efficient and accurate. A research game-changer.

Q&As

How do genetic variations in the CEACAM8 gene affect immune response and susceptibility to infections?

Genetic variations in CEACAM8 affect immune function and infection susceptibility.

How does CEACAM8 contribute to the activation and function of neutrophils?

It aids neutrophil adhesion, migration, and antibacterial functions.

What role does CEACAM8 play in inflammatory processes and immune regulation?

CEACAM8 plays a role in regulating inflammation and immune responses.

How does CEACAM8 interact with other cell adhesion molecules and signaling pathways in the immune system?

CEACAM8 works with other adhesion molecules, impacting immune cell signaling.

What is the impact of altered CEACAM8 expression in autoimmune disorders and chronic inflammation?

Altered CEACAM8 expression is linked to autoimmune diseases and chronic inflammation.

What potential therapeutic applications could arise from targeting CEACAM8 in immune-related diseases?

Targeting CEACAM8 offers potential treatments for immune-related conditions.

What is the primary function of CEACAM8 in immune response and cell signaling?

CEACAM8 is key in immune cell activation and signaling, especially in neutrophils.