Recombinant Human Chemokine (C-C motif) Ligand 24 CCL24-357H

Recombinant Human Chemokine (C-C motif) Ligand 24

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Cat.No. : CCL24-357H Optional Service: Optional requirements on this protein
Product Overview : Recombinant CCL24 isa disulfide-linked homodimeric protein consisting of 79 amino acid residuesubunits, and migrates as an approximately 9 kDa protein under non-reducing andreducing conditions in SDS-PAGE, and was lyophilzed from 0.2μm filteredconcentrated (1.0mg/ml) solution in 100mM NaCl, 10mM PB, pH 7.0.
Description : Eotaxin belongs tothe platelet factor-4 family of chemokines. The gene symbol is SCYA11. Thefactor is being referred to also as Eotaxin-1 and has been renamed CCL11.Eotaxin induces substantial accumulation of eosinophils in the skin withoutsignificantly affecting the accumulation of neutrophils. Eotaxin is a potentstimulator of both guinea pig and human eosinophils in vitro. The Eotaxinreceptor is a G-protein-coupled receptor selectively expressed in humaneosinophils.
Source : Human
Host : E. coli
Purity : >97%, asdetermined by SDS-PAGE and HPLC.
Sequence : MAGLMTIVTSLLFLGVCAHH IIPTGSVVIP SPCCMFFVSK RIPENRVVSY QLSSRSTCLK AGVIFTTKKG QQFCGDPKQEWVQRYMKNLD AKQKKASPRA RAVAVKGPVQ RYPGNQTTC
Molecular Weight : Native human CCL24has a calculated molecular mass of approximately 9 kDa.
Biological Activity : Activity wasdetermined by the ability to induce chemotaxis of purified eosinophils atconcentrations ranging between 50-100 ng/ml.
Endotoxin : Endotoxin contentwas assayed using a LAL gel clot method. Endotoxin level was found to be lessthan 0.1 ng/µg (1EU/µg).
Reconstitution : A quick spin of thevial followed by reconstitution in distilled water to a concentration notless than 0.1 mg/mL. This solution can then be diluted into other buffers.
Storage : The lyophilizedprotein is stable for at least 2 years from date of receipt at -20° C. Uponreconstitution, this cytokine can be stored in working aliquots at 2° - 8° Cfor one month, or at -20° C for six months, with a carrier protein withoutdetectable loss of activity. Avoid repeated freeze/thaw cycles.
OfficialSymbol : CCL24
Pathways : Chemokine signalingpathway; Cytokine-cytokine receptor interaction
Gene Name : CCL24chemokine (C-C motif) ligand 24 [ Homo sapiens ]
Synonyms : CCL24;chemokine (C-C motif) ligand 24; Ckb-6; MPIF2; MPIF-2; SCYA24; C-C motifchemokine 24; CK-beta-6; eotaxin-2; OTTHUMP00000210224; OTTHUMP00000210225;small-inducible cytokine A24; eosinophil chemotactic protein 2; myeloidprogenitor inhibitory factor 2; small inducible cytokine subfamily A(Cys-Cys), member 24
Gene ID : 6369
mRNA Refseq : NM_002991
Protein Refseq : NP_002982
MIM : 602495
UniProt ID : O00175
Chromosome Location : 7q11.23
Function : chemokine activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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