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Recombinant Human Chemokine (C-C motif) Ligand 24
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Cat.No. : | CCL24-357H Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant CCL24 isa disulfide-linked homodimeric protein consisting of 79 amino acid residuesubunits, and migrates as an approximately 9 kDa protein under non-reducing andreducing conditions in SDS-PAGE, and was lyophilzed from 0.2μm filteredconcentrated (1.0mg/ml) solution in 100mM NaCl, 10mM PB, pH 7.0. |
Description : | Eotaxin belongs tothe platelet factor-4 family of chemokines. The gene symbol is SCYA11. Thefactor is being referred to also as Eotaxin-1 and has been renamed CCL11.Eotaxin induces substantial accumulation of eosinophils in the skin withoutsignificantly affecting the accumulation of neutrophils. Eotaxin is a potentstimulator of both guinea pig and human eosinophils in vitro. The Eotaxinreceptor is a G-protein-coupled receptor selectively expressed in humaneosinophils. |
Source : | Human |
Host : | E. coli |
Purity : | >97%, asdetermined by SDS-PAGE and HPLC. |
Sequence : | MAGLMTIVTSLLFLGVCAHH IIPTGSVVIP SPCCMFFVSK RIPENRVVSY QLSSRSTCLK AGVIFTTKKG QQFCGDPKQEWVQRYMKNLD AKQKKASPRA RAVAVKGPVQ RYPGNQTTC |
Molecular Weight : | Native human CCL24has a calculated molecular mass of approximately 9 kDa. |
Biological Activity : | Activity wasdetermined by the ability to induce chemotaxis of purified eosinophils atconcentrations ranging between 50-100 ng/ml. |
Endotoxin : | Endotoxin contentwas assayed using a LAL gel clot method. Endotoxin level was found to be lessthan 0.1 ng/µg (1EU/µg). |
Reconstitution : | A quick spin of thevial followed by reconstitution in distilled water to a concentration notless than 0.1 mg/mL. This solution can then be diluted into other buffers. |
Storage : | The lyophilizedprotein is stable for at least 2 years from date of receipt at -20° C. Uponreconstitution, this cytokine can be stored in working aliquots at 2° - 8° Cfor one month, or at -20° C for six months, with a carrier protein withoutdetectable loss of activity. Avoid repeated freeze/thaw cycles. |
OfficialSymbol : | CCL24 |
Pathways : | Chemokine signalingpathway; Cytokine-cytokine receptor interaction |
Gene Name : | CCL24chemokine (C-C motif) ligand 24 [ Homo sapiens ] |
Synonyms : | CCL24;chemokine (C-C motif) ligand 24; Ckb-6; MPIF2; MPIF-2; SCYA24; C-C motifchemokine 24; CK-beta-6; eotaxin-2; OTTHUMP00000210224; OTTHUMP00000210225;small-inducible cytokine A24; eosinophil chemotactic protein 2; myeloidprogenitor inhibitory factor 2; small inducible cytokine subfamily A(Cys-Cys), member 24 |
Gene ID : | 6369 |
mRNA Refseq : | NM_002991 |
Protein Refseq : | NP_002982 |
MIM : | 602495 |
UniProt ID : | O00175 |
Chromosome Location : | 7q11.23 |
Function : | chemokine activity |
◆ Recombinant Protein
Ccl24-151M | Recombinant Mouse Ccl24 Protein | +Inquiry |
Ccl24-1348M | Recombinant Mouse Ccl24 Protein | +Inquiry |
CCL24-0629H | Recombinant Human CCL24 Protein, GST-Tagged | +Inquiry |
CCL24-51H | Recombinant Human CCL24 Protein | +Inquiry |
CCL24-687R | Recombinant Rhesus monkey CCL24 Protein, His-tagged | +Inquiry |
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◆ Lysates
CCL24-437HCL | Recombinant Human CCL24 cell lysate | +Inquiry |
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CCL1CCL11Ccl12CCL13CCL14CCL15CCL16CCL17CCL18CCL19CCL2CCL20CCL21Ccl21cCCL22CCL23CCL24CCL25CCL26CCL27Ccl27aCCL28CCL3CCL3L1Ccl4CCL5Ccl6CCL7CCL8Ccl9CCL4L2Ccl21aCCL4L1CCL3L3Ccl21bCcl27b
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