Species : |
Human |
Source : |
Human |
Tag : |
Non |
Description : |
Eotaxin belongs tothe platelet factor-4 family of chemokines. The gene symbol is SCYA11. Thefactor is being referred to also as Eotaxin-1 and has been renamed CCL11.Eotaxin induces substantial accumulation of eosinophils in the skin withoutsignificantly affecting the accumulation of neutrophils. Eotaxin is a potentstimulator of both guinea pig and human eosinophils in vitro. The Eotaxinreceptor is a G-protein-coupled receptor selectively expressed in humaneosinophils. |
Purity : |
>97%, asdetermined by SDS-PAGE and HPLC. |
Sequence : |
MAGLMTIVTSLLFLGVCAHH IIPTGSVVIP SPCCMFFVSK RIPENRVVSY QLSSRSTCLK AGVIFTTKKG QQFCGDPKQEWVQRYMKNLD AKQKKASPRA RAVAVKGPVQ RYPGNQTTC |
Molecular Weight : |
Native human CCL24has a calculated molecular mass of approximately 9 kDa. |
Biological Activity : |
Activity wasdetermined by the ability to induce chemotaxis of purified eosinophils atconcentrations ranging between 50-100 ng/ml. |
Endotoxin : |
Endotoxin contentwas assayed using a LAL gel clot method. Endotoxin level was found to be lessthan 0.1 ng/µg (1EU/µg). |
Reconstitution : |
A quick spin of thevial followed by reconstitution in distilled water to a concentration notless than 0.1 mg/mL. This solution can then be diluted into other buffers. |
Storage : |
The lyophilizedprotein is stable for at least 2 years from date of receipt at -20° C. Uponreconstitution, this cytokine can be stored in working aliquots at 2° - 8° Cfor one month, or at -20° C for six months, with a carrier protein withoutdetectable loss of activity. Avoid repeated freeze/thaw cycles. |
OfficialSymbol : |
CCL24 |
Pathways : |
Chemokine signalingpathway; Cytokine-cytokine receptor interaction |