Recombinant Human Chromosome 19 Open Reading Frame 10, HQ-tagged

• Cat.No.: C19orf10-5371H
• Product Overview: Recombinant human C19orf10contains 143 amino acids and a 16 aa HQ tag. Total length is 159 aa.

Specification

• Species: Human
• Source: Hordeum Vulgare
• Tag: HQ
• Description: C19orf10 is aprotein that in humans is encoded by the C19orf10 gene. C19orf10 is acytokine that shares the sequence similarity with IL17. This cytokine caninduce NF-κB activation, and stimulate the production of IL8. Both thiscytokine and IL17B are ligands for the cytokine receptor IL17RB. Studies ofthe similar gene in mice suggested that this cytokine may be aproinflammatory cytokine favoring Th2-type immune response. Two alternativelyspliced transcript variants of this gene encoding distinct isoforms have beenreported.
• Form: Lyophilized from a0.2 µm sterile filtered solution of PBS, pH 7.2.
• Molecular Weight: Projected MW = 18.1kDa. The recombinant protein migrates with an apparent MW = 24 kDa inSDS-PAGE.
• Purity: >98% by SDS-PAGE.Purified product carries no pyrogenic or pro-inflammatory contaminants, asassayed with monocyte activation test using custom human Multiplex CytokineAssay measuring IL-6, TNF-alpha and IL-1beta induction.
• Endotoxin Level: < 0.005 ng perµg of product (0.05 EU/µg) as measured by turbidimetric kinetic assay.
• Reconstitution: Centrifuge vialprior to opening. First add sterile distilled water to the vial to fully solubilizethe protein to a concentration not less than 100 µg/ml. After complete solubilizationof the protein, it can be further diluted to other aqueous solutions.
• Storage: The lyophilizedprotein, though stable at room temperature for two weeks, is best stored at-20°C. Reconstituted protein should be used immediately or stored in workingaliquots at -20°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: C19orf10

Gene Information

• Gene Name: C19orf10 chromosome 19 openreading frame 10 [ Homo sapiens ]
• Synonyms: C19orf10; chromosome19 open reading frame 10; IL25; IL27; IL-25; SF20; IL27w; R33729_1;EUROIMAGE1875335; hypothetical protein LOC56005; interleukin 25;Interleukin-25; interleukin 27 working designation; stromal cell-derivedgrowth factor; Stromal cell-derived growth factor SF20
• Gene ID: 56005
• mRNA Refseq: NM_019107
• Protein Refseq: NP_061980
• MIM: 606746
• UniProt ID: Q969H8
• Chromosome Location: 19p13.3
• Pathway: Activation ofChaperones by IRE1alpha; Diabetes pathways; Unfolded Protein Response