Active Recombinant Human CXCL5 Protein (9-78, 70 aa)
Cat.No. : | CXCL5-424C |
Product Overview : | Recombinant human ENA-78/CXCL5 (9-78a.a.) produced in E. coli is a single non-glycosylated polypeptide chain containing 70 amino acids. A fully biologically active molecule, rhENA-78/CXCL5 (9-78a.a.) has a molecular mass of 7.7 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques. |
- Specification
- Gene Information
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Description : | Epithelial cellderived neutrophilactivating peptide (ENA78) also known as C-X-C motif chemokine 5(CXCL5), is a small cytokine belonging to the CXC chemokine family. It is produced following stimulation of cells with the inflammatory cytokines interleukin-1 or tumor necrosis factor-alpha. Expression of CXCL5 has also been observed in eosinophils, and can be inhibited with the type II interferon, IFN-γ. This chemokine stimulates the chemotaxis of neutrophils possessing angiogenic properties Full length CXCL5 (78 a.a.) is cleaved at the Nterminal end by cathepsin G and chymotrypsin to ENA-74 (74 a.a.) and ENA-70 (70a.a.), with the shortened forms showing increased potency relative to full length CXCL5. CXCL5can signal through the CXCR2 receptor. |
Source : | E. coli |
Species : | Human |
Form : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Bio-activity : | The EC50 value of human ENA78/CXCL5 (9-78 a.a.) on Ca^2+ mobilization assay in CHO-K1/Gα15/hCXCR2 cells (human Gα15 and human CXCR2 stably expressed in CHO-K1 cells) is less than 50 ng/mL. |
Molecular Mass : | 7.7 kDa, observed by reducing SDS-PAGE. |
Protein Length : | 70 |
AA Sequence : | RELRCVCLQTTQGVHPKMISNLQVF AIGPQCSKVEVVASLKNGKEICLDP EAPFLKKVIQKILDGGNKEN |
Endotoxin : | < 0.2 EU/μg, determined by LAL method. |
Purity : | > 95% as analyzed by SDS-PAGE. |
Storage : | Lyophilized recombinant human ENA78/CXCL5 (9-78a.a.) remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, human ENA78/CXCL5(9-78) should be stable up to 1 week at 4 centigrade or up to 2 months at -20 centigrade. |
Storage Buffer : | Lyophilized after extensive dialysis against PBS. |
Reconstitution : | Reconstituted in ddH2O or PBS at 100 μg/mL. |
Gene Name : | CXCL5 chemokine (C-X-C motif) ligand 5 [ Homo sapiens ] |
Official Symbol : | CXCL5 |
Synonyms : | CXCL5; chemokine (C-X-C motif) ligand 5; SCYB5, small inducible cytokine subfamily B (Cys X Cys), member 5 (epithelial derived neutrophil activating peptide 78); C-X-C motif chemokine 5; ENA 78; ENA-78(1-78); small inducible cytokine B5; small-inducible cytokine B5; neutrophil-activating protein 78; neutrophil-activating peptide ENA-78; epithelial-derived neutrophil activating protein 78; epithelial-derived neutrophil-activating peptide 78; epithelial-derived neutrophil-activating protein 78; small inducible cytokine subfamily B (Cys-X-Cys), member 5 (epithelial-derived neutrophil-activating peptide 78); SCYB5; ENA-78; |
Gene ID : | 6374 |
mRNA Refseq : | NM_002994 |
Protein Refseq : | NP_002985 |
MIM : | 600324 |
UniProt ID : | P42830 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCXCL5 is implicated in promoting tumor growth and metastasis by facilitating the migration of cancer cells and modulating the tumor microenvironment.
Several clinical trials are exploring the efficacy of drugs that modulate CXCL5 levels in various diseases, including cancer, autoimmune disorders, and inflammatory conditions.
CXCL5 has been identified as a regulator of angiogenesis, influencing the formation of new blood vessels, a process crucial for tumor growth and wound healing.
CXCL5's role in recruiting cells to damaged tissues makes it a potential candidate for enhancing regenerative medicine approaches, such as tissue repair and wound healing.
CXCL5 levels can be measured in blood or tissue samples to assess the extent of inflammation, aiding in the diagnosis and monitoring of various diseases.
Customer Reviews (3)
Write a reviewIts versatility and reliability make it an indispensable asset for scientists seeking to explore the complexities of various biological systems.
Its stability and functional attributes ensure reliable imaging and facilitate the elucidation of complex protein structures.
The CXCL5 protein is known for its exceptional quality, making it a highly suitable choice for meeting diverse experimental needs.
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