Description : |
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Fc |
Form : |
Lyophilized |
Molecular Mass : |
96 kDa |
Protein Length : |
1308 |
AA Sequence : |
MKPATGLWVWVSLLVAAGTVQPSDS QSVCAGTENKLSSLSDLEQQYRALR KYYENCEVVMGNLEITSIEHNRDLS FLRSVREVTGYVLVALNQFRYLPLE NLRIIRGTKLYEDRYALAIFLNYRK DGNFGLQELGLKNLTEILNGGVYVD QNKFLCYADTIHWQDIVRNPWPSNL TLVSTNGSSGCGRCHKSCTGRCWGP TENHCQTLTRTVCAEQCDGRCYGPY VSDCCHRECAGGCSGPKDTDCFACM NFNDSGACVTQCPQTFVYNPTTFQL EHNFNAKYTYGAFCVKKCPHNFVVD SSSCVRACPSSKMEVEENGIKMCKP CTDICPKACDGIGTGSLMSAQTVDS SNIDKFINCTKINGNLIFLVTGIHG DPYNAIEAIDPEKLNVFRTVREITG FLNIQSWPPNMTDFSVFSNLVTIGG RVLYSGLSLLILKQQGITSLQFQSL KEISAGNIYITDNSNLCYYHTINWT TLFSTINQRIVIRDNRKAENCTAEG MVCNHLCSSDGCWGPGPDQCLSCRR FSRGRICIESCNLYDGEFREFENGS ICVECDPQCEKMEDGLLTCHGPGPD NCTKCSHFKDGPNCVEKCPDGLQGA NSFIFKYADPDRECHPCHPNCTQGC NGPTSHDCIYYPWTGHSTLPQHART PLIAAGVIGGLFILVIVGLTFAVYV RRKSIKKKRALRRFLETELVEPLTP SGTAPNQAQLRILKETELKRVKVLG SGAFGTVYKGIWVPEGETVKIPVAI KILNETTGPKANVEFMDEALIMASM DHPHLVRLLGVCLSPTIQLVTQLMP HGCLLEYVHEHKDNIGSQLLLNWCV QIAKGMMYLEERRLVHRDLAARNVL VKSPNHVKITDFGLARLLEGDEKEY NADGGKMPIKWMALECIHYRKFTHQ SDVWSYGVTIWELMTFGGKPYDGIP TREIPDLLEKGERLPQPPICTIDVY MVMVKCWMIDADSRPKFKELAAEFS RMARDPQRYLVIQGDDRMKLPSPND SKFFQNLLDEEDLEDMMDAEEYLVP QAFNIPPPIYTSRARIDSNRSEIGH SPPPAYTPMSGNQFVYRDGGFAAEQ GVSVPYRAPTSTIPEAPVAQGATAE IFDDSCCNGTLRKPVAPHVQEDSST QRYSADPTVFAPERSPRGELDEEGY MTPMRDKPKQEYLNPVEENPFVSRR KNGDLQALDNPEYHNASNGPPKAED EYVNEPLYLNTFANTLGKAEYLKNN ILSMPEKAKKAFDNPDYWNHSLPPR STLQHPDYLQEYSTKYFYKQNGRIR PIVAENPEYLSEFSLKPGTVLPPPP YRHRNTVV |
Purity : |
> 98% |
Applications : |
WB; ELISA; FACS; FC |
Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
Storage : |
At -20 centigrade. |
Concentration : |
1 mg/mL |
Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |