ERBB4

  • Official Full Name

    v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

  • Overview

    c-erbB-4 is the fourth member of class 1 receptor kinase family. HER-4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum. Breast tumor cell lines T47-D, MDA-MB-453, BT-474 and H3396 are found to have the highest levels of mRNA, and intermediate levels are seen in MCF-7, MDA-MB-330 and MDA-MB-361. Expression of erbB-4 is low or absent in some breast tumor cell lines such as MDA-MB-231, MDA-MB-157, MDA-MB-468, and SKBR-3.
  • Synonyms

    ERBB4; v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian); v erb a avian erythroblastic leukemia viral oncogene homolog like 4; receptor tyrosine-protein kinase erbB-4; proto-oncogene-like protein c-ErbB-4; tyrosine kinase-type cell surface receptor HER4; avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4; HER4; p180erbB4; MGC138404;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Human, Rhesus
  • Mouse
  • Rat
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • hFc
  • His
  • DDK
  • DDK|His
  • Fc
  • Fc|His
  • His(C
  • ter)
  • Flag
  • GST
  • hIgG
  • His (Fc)
  • Avi
  • human|IgG1|Fc
  • Myc
  • MYC
  • Myc|DDK
  • N/A
  • No tag
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ERBB4-622H Active Recombinant Human ERBB4, His-tagged, Biotinylated Human Cell His
Human ERBB4-623H Active Recombinant Human ERBB4, Fc-tagged, Biotinylated Human Cell Fc
Human ERBB4-77H Active Recombinant Human ERBB4(706-991) Protein, N-His-tagged Sf21 His 706-991 aa
Human ERBB4-513HFL Active Recombinant Full Length Human ERBB4 Protein, C-Flag-tagged Mammalian cells Flag
Human ERBB4-1218H Recombinant Human V-Erb-A Erythroblastic Leukemia Viral Oncogene Homolog 4 (avian), GST-tagged Insect Cell GST
Human ERBB4-288H Recombinant Human ERBB4, Fc-His tagged Human Cell Fc/His
Human ERBB4-139H Recombinant Human ERBB4 Protein, DDK-tagged Insect Cell DDK
Human ERBB4-3450H Active Recombinant Human ERBB4 Protein, GST-tagged Insect Cell GST
Human ERBB4-3451H Recombinant Human ERBB4 Protein, GST-tagged Wheat Germ GST
Human ERBB4-329H Recombinant Human ERBB4, GST-tagged, Active Sf9 Insect Cell GST
Human ERBB4-141H Recombinant Human ERBB4 Protein, DDK/HIS-tagged HEK293 DDK/His Leu33-Val532
Human ERBB4-233H Recombinant Human ERBB4, C13&N15-labeled HEK293 N/A
Human ERBB4-26848TH Recombinant Human ERBB4 N/A
Human ErbB4-7283H Recombinant Human ErbB4, His tagged Human Cell His
Human ERBB4-1126H Recombinant Human V-Erb-A Erythroblastic Leukemia Viral Oncogene Homolog 4 (avian), GST-tagged Sf9 Insect Cell GST
Human ERBB4-216H Recombinant Human ERBB4, His-tagged Insect Cell His Met1-Arg649
Human ERBB4-7284H Active Recombinant Human ERBB4 protein, His-tagged HEK293 His Gln26-Pro651
Human ERBB4-140H Recombinant Human ERBB4 Protein, DDK-tagged Insect Cell DDK Met-Gln26-Pro651
Human ERBB4-001HCL Recombinant Human ERBB4 cell lysate Insect Cell N/A
Human ERBB4-1543HCL Recombinant Human ERBB4 cell lysate Human Cell N/A
Human ERBB4-3768H Recombinant Human ERBB4 protein, GST-tagged E.coli GST 989-1308 aa
Human ERBB4-4240H Recombinant Human ERBB4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ERBB4-2116H Recombinant Human ERBB4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ErbB4-7283HAF555 Recombinant Human ErbB4 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 635
Human ErbB4-7282HAF488 Recombinant Human ERBB4 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 865
Human ERBB4-288HAF488 Recombinant Human ERBB4 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His 871
Human ERBB4-385H Recombinant Human ERBB4 Protein, His-tagged E.coli His Cys29~Asn278
Human ERBB4-2052H Recombinant Human ERBB4 Protein, Fc/His-tagged HEK293 Fc/His Gln26-Arg649
Human ERBB4-358H Recombinant Human ERBB4 protein, Fc-tagged HEK293 human/IgG1/Fc 626
Human ErbB4-7283HAF488 Recombinant Human ErbB4 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 635
Human ERBB4-04H Active Recombinant Human ERBB4 Protein, hIgG/His-tagged HEK293 hIgG/His
Human ERBB4-216HAF488 Recombinant Human ERBB4 Protein, His-tagged, Alexa Fluor 488 conjugated Insect Cell His Met1-Arg649, 635
Human ErbB4-7282HF Recombinant Human ERBB4 Protein, Fc-tagged, FITC conjugated HEK293 Fc 865
Human ErbB4-7282HAF555 Recombinant Human ERBB4 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 865
Human ERBB4-859H Recombinant Human ERBB4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ErbB4-7283HAF647 Recombinant Human ErbB4 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 635
Human ERBB4-4524HF Recombinant Full Length Human ERBB4 Protein, GST-tagged In Vitro Cell Free System GST 1308 amino acids
Human ERBB4-216HAF647 Recombinant Human ERBB4 Protein, His-tagged, Alexa Fluor 647 conjugated Insect Cell His Met1-Arg649, 635
Human ERBB4-240H Recombinant Human ERBB4 Protein, Fc-tagged HEK293 Fc 1308
Human ERBB4-69H Recombinant Human ERBB4 Protein (ECD), Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter) Gln26-Arg649
Human ERBB4-216HAF555 Recombinant Human ERBB4 Protein, His-tagged, Alexa Fluor 555 conjugated Insect Cell His Met1-Arg649, 635
Human ERBB4-288HAF647 Recombinant Human ERBB4 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His 871
Human ERBB4-288HAF555 Recombinant Human ERBB4 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His 871
Human ERBB4-1325S Recombinant Human ERBB4 Protein (R676-V1308), Tag Free Insect Cell No tag R676-V1308
Human ErbB4-7282HAF647 Recombinant Human ERBB4 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 865
Human ERBB4-216HF Recombinant Human ERBB4 Protein, His-tagged, FITC conjugated Insect Cell His Met1-Arg649, 635
Human ERBB4-239H Recombinant Human ERBB4 Protein, His-tagged HEK293 His 1308
Human ERBB4-1326S Recombinant Human ERBB4 Protein (R676-V1308), GST tagged Insect Cell GST R676-V1308
Human ErbB4-1400H Active Recombinant Human ErbB4 protein, Fc-tagged HEK293 Fc Gln26-Pro651
Human ERBB4-288HF Recombinant Human ERBB4 Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His 871
Human ERBB4-2651H Active Recombinant Human ERBB4 protein, hFc&His-tagged HEK293 hFc&His Gln26-Arg649
Human ErbB4-7283HF Recombinant Human ErbB4 Protein, His-tagged, FITC conjugated HEK293 His 635
Human ERBB4-859H-B Recombinant Human ERBB4 Protein Pre-coupled Magnetic Beads HEK293
Human ERBB4-116H Recombinant Human ERBB4 Protein, ECD, Tag Free, Biotinylated CHO Tag Free ECD
Human ERBB4-2678H Recombinant Human ERBB4 Protein (Cys29-Asn278), His tagged E.coli His Cys29-Asn278
Mouse Erbb4-473M Active Recombinant Mouse V-Erb-A Erythroblastic Leukemia Viral Oncogene Homolog 4 (avian) Mammalian cells N/A
Mouse Erbb4-7416MAF488 Active Recombinant Mouse Erbb4 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His Met1-Leu652, 638
Mouse Erbb4-7416MAF647 Active Recombinant Mouse Erbb4 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His Met1-Leu652, 638
Mouse Erbb4-7416MF Active Recombinant Mouse Erbb4 Protein, His-tagged, FITC conjugated HEK293 His Met1-Leu652, 638
Mouse Erbb4-7416MAF555 Active Recombinant Mouse Erbb4 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His Met1-Leu652, 638
Mouse Erbb4-7416M Active Recombinant Mouse Erbb4 Protein, His tagged HEK293 His Met1-Leu652
Mouse ERBB4-1417MCL Recombinant Mouse ERBB4 cell lysate Human Cell N/A
Mouse Erbb4-971M Recombinant Mouse Erbb4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Erbb4-10551M-B Recombinant Mouse Erbb4 Protein Pre-coupled Magnetic Beads HEK293
Mouse Erbb4-10551M Recombinant Mouse Erbb4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ErbB4-1253R Acitve Recombinant Rat ErbB4 protein(Met1-Pro651), His-tagged HEK293 C-His Met1-Pro651
Rat ERBB4-2134R Recombinant Rat ERBB4 Protein Mammalian Cell His
Rat Erbb4-8720R Active Recombinant Rat Erbb4 protein(Met1-Pro651), hFc-tagged HEK293 C-hFc Met1-Pro651
Rat ERBB4-217R Recombinant Rat Erbb4, His tagged Human Cell His
Rat ERBB4-895RCL Recombinant Rat ERBB4 cell lysate Human Cell N/A
Rat ERBB4-1791R-B Recombinant Rat ERBB4 Protein Pre-coupled Magnetic Beads HEK293
Rat ERBB4-217RF Recombinant Rat Erbb4 Protein, His-tagged, FITC conjugated HEK293 His 637
Rat ERBB4-217RAF555 Recombinant Rat Erbb4 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 637
Rat Erbb4-8720RAF488 Recombinant Rat Erbb4 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 867
Rat Erbb4-8720RF Recombinant Rat Erbb4 Protein, Fc-tagged, FITC conjugated HEK293 Fc 867
Rat ERBB4-217RAF647 Recombinant Rat Erbb4 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 637
Rat Erbb4-8720RAF647 Recombinant Rat Erbb4 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 867
Rat ERBB4-1791R Recombinant Rat ERBB4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Erbb4-8720RAF555 Recombinant Rat Erbb4 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 867
Rat ERBB4-217RAF488 Recombinant Rat Erbb4 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 637
Human, Rhesus ErbB4-7282H Active Recombinant Human, Rhesus ErbB4 protein, hFc-tagged HEK293 hFc Met1-Arg649
Chicken ERBB4-2237C Recombinant Chicken ERBB4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

ERBB4 involved in several pathways and played different roles in them. We selected most pathways ERBB4 participated on our site, such as ErbB signaling pathway, Calcium signaling pathway, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERBB4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ErbB signaling pathwayCAMK2A;PIK3R5;RPS6KB2;SHC1;MAP2K7;PRKCB;ERBB4;HBEGFA;PIK3R3B
Calcium signaling pathwayAVPR1A;PLCB2;RYR3;NOS2B;P2RX3A;PLCD3;EDNRB2;AGTR1;PTGER3
EndocytosisRAB10;CHMP2B;CHMP6B;TSG101A;EPS15;LDLRAP1;PIP5K1AB;WIPF1A;ADRB2A
Proteoglycans in cancerPPP1R12B;WNT2;COL21A1;BRAF;MAPK12;ARAF;PLAUR;IGF1R;PXN

ERBB4 has several biochemical functions, for example, ATP binding, epidermal growth factor receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ERBB4 itself. We selected most functions ERBB4 had, and list some proteins which have the same functions with ERBB4. You can find most of the proteins on our site.

Function Related Protein
ATP bindingCDK13;IDE;SYN2B;CSNK1G2A;SMOK2B;KIF2A;CHD8;CHEK1;FGFR1
epidermal growth factor receptor bindingYES1;BTC;SNX1;VAV2;LINGO1B;EREG;SOCS5;RNF126;MS4A1
protein bindingSCLY;CEP120;LCE1B;HOXA9;PPP6C;LACE1;P2RX4;TXNDC12;C5orf30
protein homodimerization activityATPIF1B;HMGCL;MAP3K9;KCNE2;ALS2;RBM44;SETMAR;KCNK9;APOA1BP
protein tyrosine kinase activityMAP2K7;INSRB;MAP2K4;CLK3;CSK;NTRK2B;BCR;EK1;ALK
receptor signaling protein tyrosine kinase activityKITB;LYN;ERBB3B;TYRO3;SYK;KITA;EGFR;ERBB4A;ERBB2
transcription regulatory region DNA bindingTRP63;SP1;DLX5;CTNNB1;NFKB1;Ar;H2AFY;ZNF217;NKX3
transmembrane receptor protein tyrosine kinase activityRYK;ERBB4;IGF1RB;PDGFRA;EPHB2B;EPHB4;ERBB2;ROR1;NPTNB

ERBB4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERBB4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERBB4.

ERBB2; DLG4; SHC1; ERBB3; GRB2

Research Area

Related articles

Nevoltris, D; Lombard, B; et al. Conformational Nanobodies Reveal Tethered Epidermal Growth Factor Receptor Involved in EGFR/ErbB2 Predimers. ACS NANO 9:1388-1399(2015).
D'Souza, JW; Reddy, S; et al. Combining Anti-ERBB3 Antibodies Specific for Domain I and Domain III Enhances the Anti-Tumor Activity over the Individual Monoclonal Antibodies. PLOS ONE 9:-(2014).
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