|Official Full Name||v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)|
|Background||c-erbB-4 is the fourth member of class 1 receptor kinase family. HER-4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum. Breast tumor cell lines T47-D, MDA-MB-453, BT-474 and H3396 are found to have the highest levels of mRNA, and intermediate levels are seen in MCF-7, MDA-MB-330 and MDA-MB-361. Expression of erbB-4 is low or absent in some breast tumor cell lines such as MDA-MB-231, MDA-MB-157, MDA-MB-468, and SKBR-3.|
|Synonyms||ERBB4; v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian); v erb a avian erythroblastic leukemia viral oncogene homolog like 4; receptor tyrosine-protein kinase erbB-4; proto-oncogene-like protein c-ErbB-4; tyrosine kinase-type cell surface receptor HER4; avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4; HER4; p180erbB4; MGC138404|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
erbb4 involved in several pathways and played different roles in them. We selected most pathways erbb4 participated on our site, such as ErbB signaling pathway, Calcium signaling pathway, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with erbb4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|ErbB signaling pathway||TGFA; SHC3; MAPK8A; GRB2B; MAPK1; AKT3A; MAP2K1; NRG1; GSK3B; ERBB4A|
|Calcium signaling pathway||NTSR1; MYLK2; PHKG1; GNA15; P2RX2; VDAC3; GNA15.4; SLC8A4A; CHRNA7; PLCG1|
|Endocytosis||VPS4A; PDGFRA; PLD1; ARF3; AGAP1; VPS29; CHMP7; ASAP2; ARPC1A; IL2RGA|
|Proteoglycans in cancer||MMP9; WNT8A; HSPG2; VAV2; FLNA; ROCK1; ACTB; FASLG; TGFB1; FGFR1|
erbb4 has several biochemical functions, for example, ATP binding, epidermal growth factor receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by erbb4 itself. We selected most functions erbb4 had, and list some proteins which have the same functions with erbb4. You can find most of the proteins on our site.
|ATP binding||NLRP9C; GTF2F2A; ATP2B1B; UBE2NA; ADCY6; CCT3; P2RY1; DDX42; ATP2B4; HK1|
|epidermal growth factor receptor binding||GRB2; FER; SNX4; SOCS5; ATXN2; ERBB4; RNF126; SNX2; EPGN; VAV3|
|protein binding||MED29; ATP1B1; C7orf31; NIPAL3; MYD88; GLTP; CD6; NR0B1; ADAM1B; SYTL1|
|protein homodimerization activity||PVRL2; MVD; GJC3; ATF3; RXRB; UGT1A9; ANXA1; XDH; CEBPB; CEBPE|
|protein tyrosine kinase activity||KIT; PTK2B; FES; SYK; FGFR2; EPHB4A; PTK2AA; ROS1; ERBB4; LYN|
|receptor signaling protein tyrosine kinase activity||SYK; LYN; KIT; EGFR; ERBB2; KITA; ERBB4; ERBB3B; ERBB4A; TYRO3|
|transcription regulatory region DNA binding||KLF1; DDIT3; LEF1; ZNF831; TCF7L1A; HOXA13; SALL1A; FOXI1; NKX3-1; ATF4|
|transmembrane receptor protein tyrosine kinase activity||TIE1; MUSK; ALK; NTRK2B; EPHA4B; EGFR; FLT1; NPTNB; ERBB4A; EK1|
erbb4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with erbb4 here. Most of them are supplied by our site. Hope this information will be useful for your research of erbb4.
ERBB2; DLG4; SHC1; ERBB3; GRB2