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Official Full Name v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
Background c-erbB-4 is the fourth member of class 1 receptor kinase family. HER-4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum. Breast tumor cell lines T47-D, MDA-MB-453, BT-474 and H3396 are found to have the highest levels of mRNA, and intermediate levels are seen in MCF-7, MDA-MB-330 and MDA-MB-361. Expression of erbB-4 is low or absent in some breast tumor cell lines such as MDA-MB-231, MDA-MB-157, MDA-MB-468, and SKBR-3.
Synonyms ERBB4; v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian); v erb a avian erythroblastic leukemia viral oncogene homolog like 4; receptor tyrosine-protein kinase erbB-4; proto-oncogene-like protein c-ErbB-4; tyrosine kinase-type cell surface receptor HER4; avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4; HER4; p180erbB4; MGC138404
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • NS0
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • DDK
    • His
    • Fc
    • GST
    • human
    • IgG1
    • MYC/DDK
    • Myc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Erbb4-7416M Recombinant Mouse Erbb4 Protein, His tagged HEK293 His
    Human ERBB4-2052H Recombinant Human ERBB4 Protein, Fc/His-tagged HEK293 Fc/His
    Human ERBB4-358H Recombinant Human ERBB4 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human ERBB4-4240H Recombinant Human ERBB4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Erbb4-971M Recombinant Mouse Erbb4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human ERBB4-001HCL Recombinant Human ERBB4 cell lysate Insect Cell N/A
    Human ERBB4-1126H Recombinant Human V-Erb-A Erythroblastic Leukemia Viral Oncogene Homolog 4 (avian), GST-tagged Sf9 Insect Cell GST
    Human ERBB4-1218H Recombinant Human V-Erb-A Erythroblastic Leukemia Viral Oncogene Homolog 4 (avian), GST-tagged Insect Cell GST
    Human ERBB4-139H Recombinant Human ERBB4 Protein, DDK-tagged Insect Cell DDK
    Human ERBB4-140H Recombinant Human ERBB4 Protein, DDK-tagged Insect Cell DDK
    Human ERBB4-141H Recombinant Human ERBB4 Protein, DDK/HIS-tagged HEK293 DDK/His
    Human ERBB4-1543HCL Recombinant Human ERBB4 cell lysate Human Cell N/A
    Human ERBB4-2116H Recombinant Human ERBB4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ERBB4-216H Recombinant Human ERBB4, His-tagged Insect Cell His
    Human ERBB4-233H Recombinant Human ERBB4, C13&N15-labeled HEK293 N/A
    Human ERBB4-26848TH Recombinant Human ERBB4 N/A
    Human ERBB4-288H Recombinant Human ERBB4, Fc-His tagged Human Cell Fc/His
    Human ERBB4-329H Recombinant Human ERBB4, GST-tagged, Active Sf9 Insect Cell GST
    Human ERBB4-3450H Recombinant Human ERBB4 Protein, GST-tagged Insect Cell GST
    Human ERBB4-3451H Recombinant Human ERBB4 Protein, GST-tagged Wheat Germ GST
    Human ERBB4-385H Recombinant Human ERBB4 Protein, His-tagged E.coli His
    Human ERBB4-622H Recombinant Human ERBB4, His-tagged, Biotinylated Human Cell His
    Human ERBB4-623H Recombinant Human ERBB4, Fc-tagged, Biotinylated Human Cell Fc
    Human ErbB4-7282H Recombinant Human ErbB4, Fc tagged Human Cell Fc
    Human ErbB4-7283H Recombinant Human ErbB4, His tagged Human Cell His
    Human ERBB4-7284H Recombinant Human ERBB4 protein, His-tagged HEK293 His
    Mouse ERBB4-1417MCL Recombinant Mouse ERBB4 cell lysate Human Cell N/A
    Mouse Erbb4-473M Recombinant Mouse V-Erb-A Erythroblastic Leukemia Viral Oncogene Homolog 4 (avian) NS0 N/A
    Rat ERBB4-2134R Recombinant Rat ERBB4 Protein Mammalian Cell His
    Rat ERBB4-217R Recombinant Rat Erbb4, His tagged Human Cell His
    Rat Erbb4-8720R Recombinant Rat Erbb4, Fc tagged Human Cell Fc
    Rat ERBB4-895RCL Recombinant Rat ERBB4 cell lysate Human Cell N/A
    Chicken ERBB4-2237C Recombinant Chicken ERBB4 Mammalian Cell His

    erbb4 involved in several pathways and played different roles in them. We selected most pathways erbb4 participated on our site, such as ErbB signaling pathway, Calcium signaling pathway, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with erbb4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ErbB signaling pathway TGFA; SHC3; MAPK8A; GRB2B; MAPK1; AKT3A; MAP2K1; NRG1; GSK3B; ERBB4A
    Calcium signaling pathway NTSR1; MYLK2; PHKG1; GNA15; P2RX2; VDAC3; GNA15.4; SLC8A4A; CHRNA7; PLCG1
    Endocytosis VPS4A; PDGFRA; PLD1; ARF3; AGAP1; VPS29; CHMP7; ASAP2; ARPC1A; IL2RGA
    Proteoglycans in cancer MMP9; WNT8A; HSPG2; VAV2; FLNA; ROCK1; ACTB; FASLG; TGFB1; FGFR1

    erbb4 has several biochemical functions, for example, ATP binding, epidermal growth factor receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by erbb4 itself. We selected most functions erbb4 had, and list some proteins which have the same functions with erbb4. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding NLRP9C; GTF2F2A; ATP2B1B; UBE2NA; ADCY6; CCT3; P2RY1; DDX42; ATP2B4; HK1
    epidermal growth factor receptor binding GRB2; FER; SNX4; SOCS5; ATXN2; ERBB4; RNF126; SNX2; EPGN; VAV3
    protein binding MED29; ATP1B1; C7orf31; NIPAL3; MYD88; GLTP; CD6; NR0B1; ADAM1B; SYTL1
    protein homodimerization activity PVRL2; MVD; GJC3; ATF3; RXRB; UGT1A9; ANXA1; XDH; CEBPB; CEBPE
    protein tyrosine kinase activity KIT; PTK2B; FES; SYK; FGFR2; EPHB4A; PTK2AA; ROS1; ERBB4; LYN
    receptor signaling protein tyrosine kinase activity SYK; LYN; KIT; EGFR; ERBB2; KITA; ERBB4; ERBB3B; ERBB4A; TYRO3
    transcription regulatory region DNA binding KLF1; DDIT3; LEF1; ZNF831; TCF7L1A; HOXA13; SALL1A; FOXI1; NKX3-1; ATF4
    transmembrane receptor protein tyrosine kinase activity TIE1; MUSK; ALK; NTRK2B; EPHA4B; EGFR; FLT1; NPTNB; ERBB4A; EK1

    erbb4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with erbb4 here. Most of them are supplied by our site. Hope this information will be useful for your research of erbb4.

    ERBB2; DLG4; SHC1; ERBB3; GRB2

    Nevoltris, D; Lombard, B; et al. Conformational Nanobodies Reveal Tethered Epidermal Growth Factor Receptor Involved in EGFR/ErbB2 Predimers. ACS NANO 9:1388-1399(2015).
    D'Souza, JW; Reddy, S; et al. Combining Anti-ERBB3 Antibodies Specific for Domain I and Domain III Enhances the Anti-Tumor Activity over the Individual Monoclonal Antibodies. PLOS ONE 9:-(2014).

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