Recombinant Human EXOSC10, His-tagged

• Cat.No.: EXOSC10-26640TH
• Product Overview: Recombinant full length EXOSC10 protein produced from Sf9 insect cells. This is a glycosylated, polypeptide chain with a MW of 120 kDa,with a N termial 6xHis tag.

Specification

• Species: Human
• Tag: His
• Description: Exosome component 10, also known as EXOSC10, is a human gene, the protein product of which is part of the exosome complex and is an autoantigen is patients with certain auto immune diseases, most notably scleromyositis.
• Conjugation: HIS
• Biological activity: This protein binds IgG-type human auto-antibodies and polymyositis patient sera.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 0.02% SDS, 20mM HEPES, 100mM Sodium chloride, 0.01mM EDTA, pH 7.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Contains 1 3-5 exonuclease domain.Contains 1 HRDC domain.
• Full Length: Full L.

Gene Information

• Gene Name: EXOSC10 exosome component 10 [ Homo sapiens ]
• Official Symbol: EXOSC10
• Synonyms: EXOSC10; exosome component 10; PMSCL2, polymyositis/scleroderma autoantigen 2, 100kDa; p2; p3; p4; PM Scl; PM/Scl 100; polymyositis/scleroderma autoantigen 2 (100kD); RRP6; Rrp6p
• Gene ID: 5394
• mRNA Refseq: NM_001001998
• Protein Refseq: NP_001001998
• MIM: 605960
• Uniprot ID: Q01780
• Chromosome Location: 1p36.22
• Pathway: RNA degradation, organism-specific biosystem; RNA degradation, conserved biosystem
• Function: 3-5 exonuclease activity; RNA binding; exoribonuclease activity; hydrolase activity; nucleotide binding