Recombinant Human Fas Ligand Inhibitor, Fc-tagged
Cat.No. : | FAS-37H |
Product Overview : | Produced in HEK 293 cells. The extracellular domain of human Fas (CD95; APO-1)(aa 7-154) is fused to the Fc portion of human IgG1. Purified by multi-step chromatography. |
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Species : | Human |
Tag : | Fc |
Form : | 50 μg lyophilized, contains PBS. |
Molecular Mass : | ~56 kDa |
Endotoxin : | Endotoxin content is<0.1 eu/μg purified protein as determined by lal test.>0.1> |
Purity : | ≥95% as determined by SDS-PAGE. |
Characteristic : | Inhibits the apoptosis-inducing activity of Fas Ligand. Binds FasL. |
Applications : | Functional Application: Inhibition of FAS Ligand activity in human and mouse: The apoptosis-inducing activity of FasL is inhibited by concentrations of 20-100 μg/mL of the fusion protein. |
Usage : | For in vitro research use only. Not for use in diagnostics or in humans. |
Storage : | Store at -20°C. After reconstitution, aliquot and store at -20°C. Avoid repeated freeze/thaw cycles (activity may decrease). |
Warning : | No warranties, expressed or implied, are made regarding the use of this product. Creative Biomart is not liable for any damage, personal injury, or economic loss caused by this product. |
Protein length : | 7-154 |
Gene Name : | FAS Fas (TNF receptor superfamily, member 6) [ Homo sapiens ] |
Official Symbol : | FAS |
Synonyms : | FAS; Fas (TNF receptor superfamily, member 6); APT1, FAS1, TNFRSF6, tumor necrosis factor receptor superfamily, member 6; tumor necrosis factor receptor superfamily member 6; APO 1; CD95; Fas AMA; FAS 827dupA; CD95 antigen; FASLG receptor; apoptosis antigen 1; Delta Fas/APO-1/CD95; APO-1 cell surface antigen; apoptosis-mediating surface antigen FAS; tumor necrosis factor receptor superfamily, member 6; APT1; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6; |
Gene ID : | 355 |
mRNA Refseq : | NM_000043 |
Protein Refseq : | NP_000034 |
MIM : | 134637 |
UniProt ID : | P25445 |
Chromosome Location : | 10q24.1 |
Pathway : | Activation of Pro-Caspase 8, organism-specific biosystem; Adipogenesis, organism-specific biosystem; African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Alzheimers disease, organism-specific biosystem; |
Function : | binding; identical protein binding; kinase binding; protein binding; receptor activity; receptor activity; signal transducer activity; transmembrane signaling receptor activity; tumor necrosis factor-activated receptor activity; |
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◆ Lysates | ||
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Related Gene
Fascin Is Critical for the Maintenance of Breast Cancer Stem Cell Pool Predominantly via the Activation of the Notch Self-Renewal Pathway.
Journal: Stem cells (Dayton, Ohio) PubMed ID: 27502039 Data: 2017/12/4
Authors: Rayanah Barnawi, Samiyah Al-Khaldi, Monther Al-Alwan
Article Snippet:The ALDEFLUOR? Kit which measure aldehyde dehydrogenase (ALDH) activity was purchased from StemCell Technologies.The ALDEFLUOR? Kit which measure aldehyde dehydrogenase (ALDH) activity was purchased from StemCell Technologies.. The recombinant human Notch ligand (DLLI) was purchased from Creative BioMart and the Notch signaling inhibitor (FLI-06) was purchased from Selleckchem.. Flow cytometry and cell sorting Cell surface staining and permeablization to detect fascin were performed as previously described [30].Flow cytometry and cell sorting Cell surface staining and permeablization to detect fascin were performed as previously described [30].
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewWhen experimenting with FAS, the results are very reproducible.
The stability of FAS products allows them to cope with different experimental conditions and modes of operation.
FAS has high specific activity and can exert strong biological effect at low concentration.
Q&As (6)
Ask a questionFAS protein plays an important role in cell signaling, it can activate downstream signaling pathways, such as death signaling pathway and survival signaling pathway, by binding to its ligand and transmitting signals.
It can provide a reference for clinical practice and guide the diagnosis, treatment and prevention of diseases by detecting the expression level of FAS protein and understanding its mechanism of action.
FAS protein-related diseases can be prevented and treated by regulating the expression level of FAS protein and inhibiting its signaling pathway.
Gene knockout or knockdown techniques can be used to study the function and mechanism of action of FAS proteins. By knocking out or knocking down the FAS gene, changes in processes such as apoptosis and immune response can be observed to further understand its function and mechanism of action.
FAS protein can bind to its ligand, activate the death signaling pathway, and induce apoptosis.
The expression level and activity of FAS protein can be measured to predict the prognosis and development trend of certain diseases.
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