Recombinant Human FAS Protein, Fc-tagged

Cat.No. : FAS-243H
Product Overview : Recombinant human FAS protein with Fc tag was expressed in HEK293.
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Description : The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
Source : HEK293
Species : Human
Tag : Fc
Form : Lyophilized
Molecular Mass : 42.8 kDa
Protein Length : 335
AA Sequence : MLGIWTLLPLVLTSVARLSSKSVNA QVTDINSKGLELRKTVTTVETQNLE GLHHDGQFCHKPCPPGERKARDCTV NGDEPDCVPCQEGKEYTDKAHFSSK CRRCRLCDEGHGLEVEINCTRTQNT KCRCKPNFFCNSTVCEHCDPCTKCE HGIIKECTLTSNTKCKEEGSRSNLG WLCLLLLPIPLIVWVKRKEVQKTCR KHRKENQGSHESPTLNPETVAINLS DVDLSKYITTIAGVMTLSQVKGFVR KNGVNEAKIDEIKNDNVQDTAEQKV QLLRNWHQLHGKKEAYDTLIKDLKK ANLCTLAEKIQTIILKDITSDSENS NFRNEIQSLV
Purity : > 98%
Applications : WB; ELISA; FACS; FC
Stability : This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
Storage : At -20 centigrade.
Concentration : 1 mg/mL
Storage Buffer : PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
Reconstitution : Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
Gene Name : FAS Fas (TNF receptor superfamily, member 6) [ Homo sapiens (human) ]
Official Symbol : FAS
Synonyms : FAS; Fas (TNF receptor superfamily, member 6); APT1, FAS1, TNFRSF6, tumor necrosis factor receptor superfamily, member 6; tumor necrosis factor receptor superfamily member 6; APO 1; CD95; Fas AMA; FAS 827dupA; CD95 antigen; FASLG receptor; apoptosis antigen 1; Delta Fas/APO-1/CD95; APO-1 cell surface antigen; apoptosis-mediating surface antigen FAS; tumor necrosis factor receptor superfamily, member 6; APT1; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6;
Gene ID : 355
mRNA Refseq : NM_000043
Protein Refseq : NP_000034
MIM : 134637
UniProt ID : P25445

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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Reviews
09/07/2022

    When experimenting with FAS, the results are very reproducible.

    07/29/2022

      The stability of FAS products allows them to cope with different experimental conditions and modes of operation.

      09/20/2021

        FAS has high specific activity and can exert strong biological effect at low concentration.

        Q&As (6)

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        Does FAS protein play a role in cell signaling? 10/30/2022

        FAS protein plays an important role in cell signaling, it can activate downstream signaling pathways, such as death signaling pathway and survival signaling pathway, by binding to its ligand and transmitting signals.

        Why apply knowledge of FAS proteins to clinical practice? 06/27/2022

        It can provide a reference for clinical practice and guide the diagnosis, treatment and prevention of diseases by detecting the expression level of FAS protein and understanding its mechanism of action.

        How can diseases associated with FAS protein be prevented and treated? 05/13/2022

        FAS protein-related diseases can be prevented and treated by regulating the expression level of FAS protein and inhibiting its signaling pathway.

        How can gene knockout or knockdown techniques be used to study the function of FAS proteins? 03/31/2021

        Gene knockout or knockdown techniques can be used to study the function and mechanism of action of FAS proteins. By knocking out or knocking down the FAS gene, changes in processes such as apoptosis and immune response can be observed to further understand its function and mechanism of action.

        What is the role of FAS protein in apoptosis? 09/29/2020

        FAS protein can bind to its ligand, activate the death signaling pathway, and induce apoptosis.

        How can FAS protein be used to predict disease prognosis? 06/19/2020

        The expression level and activity of FAS protein can be measured to predict the prognosis and development trend of certain diseases.

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