Recombinant Human FBXW11 Protein, GST-tagged

• Cat.No.: FBXW11-3967H
• Product Overview: Human FBXW11 full-length ORF ( AAH26213, 1 a.a. - 529 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 83.93 kDa
• AA Sequence: MEPDSVIEDKTIELMNTSVMEDQNE DESPKKNTLWQISNGTSSVIVSRKR PSEGNYQKEKDLCIKYFDQWSESDQ VEFVEHLISRMCHYQHGHINSYLKP MLQRDFITALPEQGLDHIAENILSY LDARSLCAAELVCKEWQRVISEGML WKKLIERMVRTDPLWKGLSERRGWD QYLFKNRPTDGPPNSFYRSLYPKII QDIETIESNWRCGRHNLQRIQCRSE NSKGVYCLQYDDEKIISGLRDNSIK IWDKTSLECLKVLTGHTGSVLCLQY DERVIVTGSSDSTVRVWDVNTGEVL NTLIHHNEAVLHLRFSNGLMVTCSK DRSIAVWDMASATDITLRRVLVGHR AAVNVVDFDDKYIVSASGDRTIKVW STSTCEFVRTLNGHKRGIACLQYRD RLVVSGSSDNTIRLWDIECGACLRV LEGHEELVRCIRFDNKRIVSGAYDG KIKVWDLQAALDPRAPASTLCLRTL VEHSGRVFRLQFDEFQIISSSHDDT ILIWDFLNVPPSAQNETRSPSRTYT YISR
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: FBXW11 F-box and WD repeat domain containing 11 [ Homo sapiens ]
• Official Symbol: FBXW11
• Synonyms: FBXW11; F-box and WD repeat domain containing 11; F box and WD 40 domain protein 1B , F box and WD 40 domain protein 11 , FBXW1B; F-box/WD repeat-containing protein 11; BTRC2; BTRCP2; Fbw1b; Fbw11; Hos; KIAA0696; F-box protein Fbw1b; homologous to Slimb protein; F-box and WD-40 domain protein 11; F-box and WD-40 domain protein 1B; F-box/WD repeat-containing protein 1B; F-box and WD repeats protein beta-TrCP2; beta-transducin repeat-containing protein 2; FBW1B; FBXW1B
• Gene ID: 23291
• mRNA Refseq: NM_012300
• Protein Refseq: NP_036432
• MIM: 605651
• UniProt ID: Q9UKB1