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Recombinant Human FGF2, StrepII-tagged

Cat.No. : FGF2-293H
Product Overview : Purified, full-length human recombinant bFGF (FGF2) protein (amino acids 2-288, 287 a.a.) with StrepII tag, produced in human cells. Predicted molecular weight: 30.6 kDa. (Accession NP_001997.5; UniProt P09038)
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Description : FGF2 is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. It plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration, and has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth.
Source : Human Cells
Species : Human
Tag : StrepII
Form : Lyophilized from sterile 0.2μm filtered solution in 0.3X PBS with 10% Trehalose (carrier-free)
Protein length : 2-288, 287 a.a.
AA Sequence : VGVGGGDVEDVTPRPGGCQISGRGA RGCNGIPGAAAWEAALPRRRPRRHP SVNPRSRAAGSPRTRGRRTEERPSG SRLGDRGRGRALPGGRLGGRGRGRA PERVGGRGRGRGTAAPRAAPAARGS RPGPAGTMAAGSITTLPALPEDGGS GAFPPGHFKDPKRLYCKNGGFFLRI HPDGRVDGVREKSDPHIKLQLQAEE RGVVSIKGVCANRYLAMKEDGRLLA SKCVTDECFFFERLESNNYNTYRSR KYTSWYVALKRTGQYKLGSKTGPGQ KAILFLPMSAKS
Endotoxin : <0.1 eu per μg protein by lal
Purity : 85% by SDS-PAGE
Storage : 12 months at -20°C as supplied; 1 month at 4°C after reconstitution. Avoid freeze/thaw cycles.
Reconstitution : Centrifuge the vial prior to opening. Reconstitute in PBS to a concentration of 0.1 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for up to 1 month.
Gene Name : FGF2 fibroblast growth factor 2 (basic) [ Homo sapiens ]
Official Symbol : FGF2
Synonyms : FGF2; fibroblast growth factor 2 (basic); FGFB; fibroblast growth factor 2; prostatropin; heparin-binding growth factor 2; basic fibroblast growth factor bFGF; BFGF; FGF-2; HBGF-2;
Gene ID : 2247
mRNA Refseq : NM_002006
Protein Refseq : NP_001997
MIM : 134920
UniProt ID : P09038
Chromosome Location : 4q26
Pathway : Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Downstream signaling of activated FGFR, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; FGFR ligand binding and activation, organism-specific biosystem; FGFR1 ligand binding and activation, organism-specific biosystem; FGFR1b ligand binding and activation, organism-specific biosystem; FGFR1c ligand binding and activation, organism-specific biosystem;
Function : chemoattractant activity; cytokine activity; fibroblast growth factor binding; fibroblast growth factor receptor binding; growth factor activity; heparin binding; ligand-dependent nuclear receptor transcription coactivator activity; protein binding; protein tyrosine kinase activity; voltage-gated calcium channel activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the biological function of FGF2? 11/10/2022

FGF2 promotes cell migration and angiogenesis and regulates bone homeostatic balance.

Where is FGF2 mainly expressed? 10/22/2022

FGF2 is widely expressed in the nervous system.

In which tissues of sheep is FGF2 primarily expressed? 01/01/2022

FGF2 is mainly expressed in tissues such as mammary glands and ovaries of sheep.

What protein does FGF2 share high homology with? 03/08/2021

FGF1 has a high degree of homology with FGF2.

What diseases is FGF2 involved in? 02/12/2021

FGF2 is involved in diseases such as cardiovascular disease, breast disease and bone homeostasis.

How does FGF2 regulate bone homeostasis? 11/21/2020

FGF2 negatively regulates bone homeostasis.

Customer Reviews (2)

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Reviews
07/14/2022

    The technical expert communicated with me in time to understand the progress of my experiment and gave me suggestions for improvement.

    02/04/2022

      The purchased protein is suitable for WB experiments and I am satisfied with the results.

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