Recombinant Human FGF2, StrepII-tagged

• Cat.No.: FGF2-293H
• Product Overview: Purified, full-length human recombinant bFGF (FGF2) protein (amino acids 2-288, 287 a.a.) with StrepII tag, produced in human cells. Predicted molecular weight: 30.6 kDa. (Accession NP_001997.5; UniProt P09038)

Specification

• Description: FGF2 is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. It plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration, and has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth.
• Source: Human Cells
• Species: Human
• Tag: StrepII
• Form: Lyophilized from sterile 0.2μm filtered solution in 0.3X PBS with 10% Trehalose (carrier-free)
• Protein length: 2-288, 287 a.a.
• AA Sequence: VGVGGGDVEDVTPRPGGCQISGRGA RGCNGIPGAAAWEAALPRRRPRRHP SVNPRSRAAGSPRTRGRRTEERPSG SRLGDRGRGRALPGGRLGGRGRGRA PERVGGRGRGRGTAAPRAAPAARGS RPGPAGTMAAGSITTLPALPEDGGS GAFPPGHFKDPKRLYCKNGGFFLRI HPDGRVDGVREKSDPHIKLQLQAEE RGVVSIKGVCANRYLAMKEDGRLLA SKCVTDECFFFERLESNNYNTYRSR KYTSWYVALKRTGQYKLGSKTGPGQ KAILFLPMSAKS
• Endotoxin: <0.1 eu per μg protein by lal
• Purity: 85% by SDS-PAGE
• Storage: 12 months at -20°C as supplied; 1 month at 4°C after reconstitution. Avoid freeze/thaw cycles.
• Reconstitution: Centrifuge the vial prior to opening. Reconstitute in PBS to a concentration of 0.1 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for up to 1 month.

Gene Information

• Gene Name: FGF2 fibroblast growth factor 2 (basic) [ Homo sapiens ]
• Official Symbol: FGF2
• Synonyms: FGF2; fibroblast growth factor 2 (basic); FGFB; fibroblast growth factor 2; prostatropin; heparin-binding growth factor 2; basic fibroblast growth factor bFGF; BFGF; FGF-2; HBGF-2
• Gene ID: 2247
• mRNA Refseq: NM_002006
• Protein Refseq: NP_001997
• MIM: 134920
• UniProt ID: P09038
• Chromosome Location: 4q26
• Pathway: Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Downstream signaling of activated FGFR, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; FGFR ligand binding and activation, organism-specific biosystem; FGFR1 ligand binding and activation, organism-specific biosystem; FGFR1b ligand binding and activation, organism-specific biosystem; FGFR1c ligand binding and activation, organism-specific biosystem
• Function: chemoattractant activity; cytokine activity; fibroblast growth factor binding; fibroblast growth factor receptor binding; growth factor activity; heparin binding; ligand-dependent nuclear receptor transcription coactivator activity; protein binding; protein tyrosine kinase activity; voltage-gated calcium channel activity

Reviews

07/14/2022

The technical expert communicated with me in time to understand the progress of my experiment and gave me suggestions for improvement.

02/04/2022

The purchased protein is suitable for WB experiments and I am satisfied with the results.

Q&As

What is the biological function of FGF2?

FGF2 promotes cell migration and angiogenesis and regulates bone homeostatic balance.

Where is FGF2 mainly expressed?

FGF2 is widely expressed in the nervous system.

In which tissues of sheep is FGF2 primarily expressed?

FGF2 is mainly expressed in tissues such as mammary glands and ovaries of sheep.

What protein does FGF2 share high homology with?

FGF1 has a high degree of homology with FGF2.

What diseases is FGF2 involved in?

FGF2 is involved in diseases such as cardiovascular disease, breast disease and bone homeostasis.

How does FGF2 regulate bone homeostasis?

FGF2 negatively regulates bone homeostasis.