Recombinant Human FGFR1 protein, DDK/His-tagged
Cat.No. : | FGFR1-210H |
Product Overview : | Recombinant Human FGFR1(Arg22-Glu376), transcript variant 1, fused with DDK/His tag at C-terminal was expressed in HEK293. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. |
Source : | HEK293 |
Species : | Human |
Tag : | DDK/His |
Form : | 1 x PBS, pH7.4, 10% glycerol |
Molecular Mass : | 42 Kda |
Protein length : | Arg22-Glu376 |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | FGFR1 fibroblast growth factor receptor 1 [ Homo sapiens ] |
Official Symbol : | FGFR1 |
Synonyms : | FGFR1; fibroblast growth factor receptor 1; FLT2, fms related tyrosine kinase 2 , KAL2; BFGFR; CD331; CEK; FLG; H2; H3; H4; H5; N SAM; Pfeiffer syndrome; FGFR1/PLAG1 fusion; proto-oncogene c-Fgr; FMS-like tyrosine kinase 2; hydroxyaryl-protein kinase; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; basic fibroblast growth factor receptor 1; OGD; FLT2; KAL2; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; bFGF-R-1; FLJ99988; |
Gene ID : | 2260 |
mRNA Refseq : | NM_023110 |
Protein Refseq : | NP_075598 |
MIM : | 136350 |
UniProt ID : | P11362 |
Products Types
◆ Recombinant Protein | ||
FGFR1-715H | Recombinant Human FGFR1 Protein, His-tagged | +Inquiry |
FGFR1-2054H | Recombinant Human FGFR1 Protein, MYC/DDK-tagged | +Inquiry |
FGFR1-1275H | Acitve Recombinant Human FGFR1 protein(Met1-Lys310), hFc-tagged | +Inquiry |
FGFR1-4407H | Recombinant Human FGFR1 Protein, His (Fc)-Avi-tagged | +Inquiry |
FGFR1-1348H | Recombinant Human FGFR1 protein(Ala1-Lys221), hFc-tagged | +Inquiry |
◆ Lysates | ||
FGFR1-2133MCL | Recombinant Mouse FGFR1 cell lysate | +Inquiry |
FGFR1-1171CCL | Recombinant Cynomolgus FGFR1 cell lysate | +Inquiry |
FGFR1-476HCL | Recombinant Human FGFR1 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1590 | FGFR1 Functional Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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