FGFR1

  • Official Full Name

    fibroblast growth factor receptor 1

  • Overview

    Fibroblast growth factor receptor 1 (FGFR1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome, and CD331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. FGFR1 has been shown to be associated with Pfeiffer syndrome.
  • Synonyms

    FLG; FGFR1; fibroblast growth factor receptor 1; CEK; OGD; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; FLJ99988; bFGF-R-1; OTTHUMP00000190874; OTTHUMP00000190875; OTTHUMP00000190876; OTTHUMP00000190877; OTTHUMP00000190879; OTTHUMP00000190880; OTTHUMP00000190881; OTTHUMP00000190885; proto-oncogene c-Fgr; FMS-like tyrosine kinase 2; hydroxyaryl-protein kinase; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; H2; H3; H4; H5; Basic fibroblast growth factor receptor 1; N sam tyrosine kinase; Protein tyrosine kinase; Tyrosylprotein kinase; Hydroxyaryl protein kinase; Heparin binding growth factor receptor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Cynomolgus Monkey
  • Gallus gallus (Chicken)
  • Human
  • Human
  • Monkey
  • Mouse
  • Rat
  • Rhesus
  • Rhesus Macaque
  • Xenopus laevis (African clawed frog)
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • Human cells
  • Human Cells
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21
  • Sf9 Insect Cell
  • SF9 insect cells
  • Wheat Germ
  • Yeast
  • C
  • hFc
  • His
  • DDK|His
  • Fc
  • Fc|His
  • His(C
  • ter)
  • Flag
  • GST
  • GST|His
  • his
  • His (Fc)
  • Avi
  • His|GST
  • His|S
  • His|T7
  • sumostar
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • Strep
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FGFR1-605H Active Recombinant Human FGFR1, His-tagged, Biotinylated Human Cell His
Human FGFR1-697H Active Recombinant Human FGFR1 Protein, Fc Chimera Mammalian cells Fc
Human FGFR1-606H Active Recombinant Human FGFR1, Fc-tagged, Biotinylated Human Cell Fc
Human FGFR1-236H Active Recombinant Human FGFR1 Protein, His & GST-tagged Insect Cell His/GST
Human FGFR1-1405H Active Recombinant Human FGFR1, GST-tagged Sf9 Insect Cell GST 399-822 aa
Human FGFR1-236HAF555 Active Recombinant Human FGFR1 Protein, His/GST-tagged, Alexa Fluor 555 conjugated Insect Cell His/GST 658
Human FGFR1-236HAF488 Active Recombinant Human FGFR1 Protein, His/GST-tagged, Alexa Fluor 488 conjugated Insect Cell His/GST 658
Human FGFR1-82H Active Recombinant Human FGFR1(456-765) Protein, N-GST-tagged Sf21 GST 456-765 aa
Human FGFR1-1275H Acitve Recombinant Human FGFR1 protein(Met1-Lys310), hFc-tagged HEK293 C-hFc Met1-Lys310
Human FGFR1-236HAF647 Active Recombinant Human FGFR1 Protein, His/GST-tagged, Alexa Fluor 647 conjugated Insect Cell His/GST 658
Human FGFR1-236HF Active Recombinant Human FGFR1 Protein, His/GST-tagged, FITC conjugated Insect Cell His/GST 658
Human FGFR1-81H Active Recombinant Human FGFR1(V561M)(456-765) Mutation Protein, N-GST-tagged Sf21 GST 456-765 aa
Human FGFR1-316H Recombinant Human Fibroblast Growth Factor Receptor 1, His-tagged HEK293 His
Human FGFR1-138H Recombinant Human FGFR1, Fc-His tagged Human Cell Fc/His
Human FGFR1-28890TH Recombinant Human FGFR1 N/A
Human FGFR1-8305H Recombinant Human FGFR1 Mammalian cells N/A
Human FGFR1-28886TH Recombinant Human FGFR1 N/A
Human FGFR1-312H Recombinant Human FGFR1, GST-tagged, Active Sf9 Insect Cell GST
Human FGFR1-207H Recombinant Human FGFR1 protein, His-tagged HEK293 His Ala1-Lys221
Human FGFR1-28834TH Recombinant Human FGFR1 N/A
Human FGFR1-485H Recombinant Human Fibroblast Growth Factor Receptor 1(IIIb) Mammalian cells N/A
Human FGFR1-18H Recombinant Human FGFR1 protein, His-tagged HEK293 His 355
Human FGFR1-111H Recombinant Human FGFR1 protein, T7/His-tagged E.coli T7/His
Human FGFR1-498H Recombinant Human FGFR1, Fc Chimera HEK293 Fc
Human FGFR1-208H Recombinant Human FGFR1 protein, DDK/His-tagged HEK293 DDK/His Arg22-Tyr374
Human FGFR1-486H Recombinant Human Fibroblast Growth Factor Receptor 1(IIIc) Mammalian cells N/A
Human FGFR1-210H Recombinant Human FGFR1 protein, DDK/His-tagged HEK293 DDK/His Arg22-Glu376
Human FGFR1-487H Recombinant Human Fibroblast Growth Factor Receptor 1 Beta Mammalian cells N/A
Human FGFR1-211H Recombinant Human FGFR1 protein, His-tagged Insect Cell His Met1 - Glu376
Human FGFR1-01H Recombinant Human Fibroblast Growth Factor Receptor 1, Fc-tagged Insect Cell Fc
Human FGFR1-45H Recombinant Human FGFR1 protein, Flag-tagged, Biotinylated Insect Cell Flag
Human FGFR1-4843H Recombinant Human Fibroblast Growth Factor Receptor 1, GST-tagged Sf9 Insect Cell GST
Human FGFR1-5417H Recombinant Human Fibroblast Growth Factor Receptor 1, His-tagged Insect Cell his
Human FGFR1-2765HCL Recombinant Human FGFR1 cell lysate Human Cell N/A
Human FGFR1-476HCL Recombinant Human FGFR1 cell lysate Insect Cell N/A
Human FGFR1-384H Recombinant Human FGFR1 protein, Strep-tagged HEK293 Strep 355
Human FGFR1-4121H Active Recombinant Human FGFR1 Protein, GST/His-tagged Insect Cell GST/His
Human FGFR1-362HB Recombinant Human FGFR1 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi It contains Arg22-Glu374.
Human FGFR1-5404H Recombinant Human FGFR1 protein, His-sumostar-tagged Yeast His-sumostar 22-376aa
Human FGFR1-5375H Recombinant Human FGFR1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FGFR1-1133H Active Recombinant Human FGFR1 Protein, His-tagged HEK293 His
Human FGFR1-28H Recombinant Active Human FGFR1 (W666R) Mutant Protein, GST-tagged Insect Cell GST
Human FGFR1-91H Recombinant Active Human FGFR1 Protein (ECD), Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter) Arg22-Glu376
Human FGFR1-2915H Recombinant Human FGFR1 protein, His-tagged E.coli His 22-376aa
Human FGFR1-1414H Recombinant Human FGFR1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FGFR1-138HAF488 Recombinant Human FGFR1 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His 512
Human FGFR1-1134H Recombinant Human FGFR1 Protein (Trp471-Arg821), N-His tagged E.coli N-His Trp471-Arg821
Human FGFR1-138HAF647 Recombinant Human FGFR1 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His 512
Human FGFR1-2914H Recombinant Human FGFR1 protein, His-tagged E.coli His 156-376aa
Human FGFR1-138HF Recombinant Human FGFR1 Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His 512
Human FGFR1-0260H Recombinant Human FGFR1 protein, His-tagged HEK293 His Met1-Lys310
Human FGFR1-4885HF Recombinant Full Length Human FGFR1 Protein, GST-tagged In Vitro Cell Free System GST 731 amino acids
Human FGFR1-4884HF Recombinant Full Length Human FGFR1 Protein In Vitro Cell Free System 1,025 amino acids
Human FGFR1-034H Recombinant Human FGFR1 Protein, His-tagged E.coli His
Human FGFR1-2325H Recombinant Human FGFR1 protein(Met1-Glu285), hFc-tagged HEK293 C-hFc Met1-Glu285
Human FGFR1-1056HFL Recombinant Full Length Human FGFR1 Protein, C-Flag-tagged Mammalian cells Flag
Human FGFR1-247H Recombinant Human FGFR1 Protein, Strep-tagged HEK293 Strep 822
Human FGFR1-142F Active Recombinant Human FGFR1 Protein (592 aa), Fc-tagged SF9 insect cells Fc 592
Human FGFR1-4122H Recombinant Human FGFR1 Protein Wheat Germ N/A
Human FGFR1-4407H Recombinant Human FGFR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human FGFR1-4407H-B Recombinant Human FGFR1 Protein Pre-coupled Magnetic Beads HEK293
Human FGFR1-246H Recombinant Human FGFR1 Protein, His-tagged HEK293 His 822
Human FGFR1-4123H Recombinant Human FGFR1 Protein, GST-tagged Wheat Germ GST
Human FGFR1-4112H Recombinant Human FGFR1 Protein (Met1-Glu285), C-His tagged Mammalian cells C-His Met1-Glu285
Human FGFR1-2856H Recombinant Human FGFR1 Protein (Met1-Pro285), C-His tagged Mammalian cells C-His Met1-Pro285
Human FGFR1-1348H Recombinant Human FGFR1 protein(Ala1-Lys221), hFc-tagged HEK293 C-hFc Ala1-Lys221
Human FGFR1-2054H Recombinant Human FGFR1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human FGFR1-138HAF555 Recombinant Human FGFR1 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His 512
Human FGFR1-2056H Recombinant Human FGFR1 Protein, His-tagged Insect Cell His
Human FGFR1-715H Recombinant Human FGFR1 Protein, His-tagged Insect Cell His 22-374 aa
Human FGFR1-362H Recombinant Human FGFR1 protein, His-Avi-tagged HEK293 His-Avi Arg22-Glu374
Human FGFR1-1895H Recombinant Human FGFR1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FGFR1-153H Recombinant Human FGFR1 Protein, His-tagged Human cells His
Human FGFR1-152H Recombinant Human FGFR1 Protein, His-tagged Human Cells His
Human FGFR1-151H Recombinant Human FGFR1 Protein, His-tagged Human Cells His
Mouse Fgfr1-4015M Active Recombinant Mouse Fgfr1 protein(Met1-Glu376), hFc-tagged HEK293 C-hFc Met1-Glu376
Mouse Fgfr1-4016M Recombinant Mouse Fgfr1 protein, His-tagged HEK293 His Met1-Glu376
Mouse FGFR1-2133MCL Recombinant Mouse FGFR1 cell lysate Human Cell N/A
Mouse Fgfr1-4016MAF488 Recombinant Mouse Fgfr1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 366
Mouse Fgfr1-4015MF Recombinant Mouse Fgfr1 Protein, Fc-tagged, FITC conjugated HEK293 Fc 596
Mouse Fgfr1-3000M Recombinant Mouse Fgfr1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Fgfr1-4015MAF488 Recombinant Mouse Fgfr1 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 596
Mouse Fgfr1-4015MAF555 Recombinant Mouse Fgfr1 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 596
Mouse Fgfr1-4016MAF555 Recombinant Mouse Fgfr1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 366
Mouse Fgfr1-4015MAF647 Recombinant Mouse Fgfr1 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 596
Mouse Fgfr1-4016MAF647 Recombinant Mouse Fgfr1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 366
Mouse Fgfr1-4016MF Recombinant Mouse Fgfr1 Protein, His-tagged, FITC conjugated HEK293 His 366
Rat Fgfr1-2339R Recombinant Rat Fgfr1 protein, His-tagged HEK293 His 22-376 aa
Rat FGFR1-2338R Recombinant Rat Fgfr1 protein, His/T7-tagged E.coli His/T7 Arg22~Glu376
Rat Fgfr1-1800R Recombinant Rat Fgfr1 protein, His & S-tagged E.coli His/S Met1~Glu89
Monkey FGFR1-66RAF488 Recombinant Monkey FGFR1 Protein, His-tagged, Alexa Fluor 488 conjugated His
Monkey FGFR1-66RAF555 Recombinant Monkey FGFR1 Protein, His-tagged, Alexa Fluor 555 conjugated His
Monkey FGFR1-8817RAF488 Recombinant Monkey FGFR1 Protein, Fc-tagged, Alexa Fluor 488 conjugated Fc
Monkey FGFR1-8817RAF555 Recombinant Monkey FGFR1 Protein, Fc-tagged, Alexa Fluor 555 conjugated Fc
Monkey FGFR1-66RF Recombinant Monkey FGFR1 Protein, His-tagged, FITC conjugated His
Monkey FGFR1-8817RF Recombinant Monkey FGFR1 Protein, Fc-tagged, FITC conjugated Fc
Monkey FGFR1-66RAF647 Recombinant Monkey FGFR1 Protein, His-tagged, Alexa Fluor 647 conjugated His
Monkey FGFR1-8817RAF647 Recombinant Monkey FGFR1 Protein, Fc-tagged, Alexa Fluor 647 conjugated Fc
Cynomolgus Monkey FGFR1-55C Recombinant Cynomolgus FGFR1, Fc tagged Mammalian Cell Fc
Cynomolgus Monkey FGFR1-67C Recombinant Cynomolgus FGFR1 protein, His-tagged HEK293 His
Cynomolgus Monkey FGFR1-1171CCL Recombinant Cynomolgus FGFR1 cell lysate Human Cell N/A
Cynomolgus Monkey FGFR1-5C-B Recombinant Cynomolgus Monkey FGFR1 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey FGFR1-5C Recombinant Cynomolgus Monkey FGFR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Gallus gallus (Chicken) RFL14852GF Recombinant Full Length Chicken Fibroblast Growth Factor Receptor 1(Fgfr1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-819)
Rhesus FGFR1-8817C Active Recombinant Rhesus FGFR1 protein, hFc-tagged HEK293 hFc Met1-Tyr283
Rhesus Macaque FGFR1-1704R Recombinant Rhesus monkey FGFR1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque FGFR1-66C Recombinant Rhesus FGFR1 protein, His-tagged HEK293 His Met1-Tyr283
Rhesus Macaque FGFR1-1526R Recombinant Rhesus Macaque FGFR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque FGFR1-1526R-B Recombinant Rhesus Macaque FGFR1 Protein Pre-coupled Magnetic Beads HEK293
Xenopus laevis (African clawed frog) RFL5885XF Recombinant Full Length Xenopus Laevis Fibroblast Growth Factor Receptor 1(Fgfr1) Protein, His-Tagged E.coli expression system His Full Length (21-812)
Chicken FGFR1-7059C Recombinant Chicken FGFR1 Mammalian Cell His
Kit-1590 FGFR1 Functional Assay Kit N/A
Kit-1557 U2OS FGFR1 Bioassay Kit N/A
  • Background
  • Quality Guarantee
  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • FGFR1 Related Signal Pathway

What is fgfr1 protein?

FGFR1 protein stands for Fibroblast Growth Factor Receptor 1. It is a transmembrane receptor tyrosine kinase that is integral to many important biological processes:FGFR1 helps mediate the effects of fibroblast growth factors (FGFs), which are involved in processes like embryonic development, cell differentiation, cell proliferation, tumor growth, and angiogenesis.When FGFs bind to FGFR1, it causes FGFR1 to dimerize and autophosphorylate its cytoplasmic tyrosine kinase domains.This leads to activation of downstream signaling cascades like Ras-MAPK, PI3K-Akt, and PLCγ pathways.

FGFR1 is expressed in many tissues including epithelial, neuronal, endothelial cells during development and tumorigenesis.Gain-of-function mutations in FGFR1 can cause diseases by overactivating downstream signaling. Loss of function mutations also lead to diseases.FGFR1 play essential roles in development of tissues like bone, brain, lungs. It also contributes to wound healing, regeneration and various cancers when dysregulated.FGFR1 is a key cell surface receptor that mediates many critical FGF-induced biological functions through activation of intracellular signaling pathways upon ligand binding.

What is the function of fgfr1 protein?

Signal transduction: FGFR1 acts as a receptor for fibroblast growth factors (FGFs) on the cell surface. Binding of FGF ligands causes FGFR1 dimerization and autophosphorylation of its tyrosine kinase domains. This leads to activation of intracellular signaling cascades like Ras-MAPK, PI3K-Akt, PLCγ pathways.

Cell proliferation: FGFR1 signaling promotes proliferation of many cell types during development and tissue repair. It plays a role in regulating cell cycle progression, mitosis, and is crucial for growth and survival.

Embryonic development: FGFR1 signaling controls key processes like angiogenesis, limb development, bone formation, organogenesis etc. Important for development of tissues like lung, brain, bone during embryonic morphogenesis.

Fgfr1 related signaling pathway

RAS-MAPK pathway: Binding of FGF ligands leads to autophosphorylation and recruitment of FGFR substrate 2 (FRS2). This activates RAS, RAF, MEK and ERK kinases inducing gene expression changes influencing proliferation, differentiation and survival.

PI3K-Akt pathway: FRS2 also recruits and activates PI3K, leading to phosphorylation and activation of Akt. This pathway regulates cell growth, survival and metabolism.

PLCγ pathway: PLCγ is phosphorylated by FGFR1 inducing downstream PKC and calcium signaling regulating various cellular responses.

Fgfr1 Related Diseases

  •  Kallmann Syndrome: Genetic defect in FGFR1 causes hypogonadotropic hypogonadism and anosmia.
  •  Pfeiffer Syndrome: Dominant FGFR1/FGFR2 mutations lead to craniosynostosis, limb/digital anomalies.
  •  Bladder cancer: FGFR3-TACC3 gene fusions activate FGFR1 signaling driving invasive phenotypes.
  •  Cancer therapeutic target: Inhibitors targeting FGFR1 signaling show promise in clinical trials for advanced cancers dependent on FGFR activation.
  •  Angiogenesis modulator: Agents modulating FGFR1 activity influence neovascularization, have scope in treating ischemic diseases and cancer anti-angiogenic strategies.

Biomedical Application of fgfr1 Protein

  •  Cancer therapeutic target: Inhibitors targeting FGFR1 signaling show promise in clinical trials for advanced cancers dependent on FGFR activation.
  •  Biomarker for cancer diagnosis: FGFR1 amplification, mutation, expression status used to classify cancer subtypes and guide targeted therapies.
  •  Tissue regeneration: FGFR1 plays roles in development; enhancing its signaling may aid wound healing, organ reconstruction in regenerative medicine.
  •  Tissue regeneration: FGFR1 plays roles in development; enhancing its signaling may aid wound healing, organ reconstruction in regenerative medicine.

High Purity

FGFR1

Fig1. SDS-PAGE (FGFR1-18H)

High Bioactivity & Detection Sensitivity

FGFR1

Fig2. Immobilized humen FGF10 (10573-HNAE) at 10 μg/ml (100 μl/well) can bind Rhesus FGFR1-Fc with a linear range of 31.25-2000 ng/mL.2. Measured by its ability to inhibit FGF-acidic dependent proliferation of Balb/c 3T3 mouse fibroblasts. The ED50 for this effect is typically 0.1-0.6 ng/Ml

FGFR1

(Cheng-Hsiang Kuo, 2015)

Fig3. rTMD23 proteins interact with syndecan-4 and FGFR1. rTMD23 pull-down assay. The pull-down complex was analysed by western blot with antibodies against FGFR1, syndecan-4, and α-tubulin. (A) Pull-down assay in HUVECs. (B) Pull-down assay in FGFR1-expressing HEK293 cells.

FGFR1

Fig4. rTMD23 enhances the phosphorylation of FGFR1. After serum-deprived starvation, HUVECs or HEK293 cells were stimulated with various rTMD23 proteins for the indicated time. Cell lysates were analysed by western blot with specific antibodies against phosphorylated FGFR1-Y653/654, FGFR1, and α-tubulin. (A) rTMD23 enhances the phosphorylation of FGFR1 in HUVECs in a dose-dependent manner. (B) The PD173074 compound suppresses the activation of FGFR1 in FGFR1-expressing HEK293 cells.

FGFR1 involved in several pathways and played different roles in them. We selected most pathways FGFR1 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGFR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayMAPK6;CACNG4;RASGRP3;FGF18;MAP4K3;NTF3;GNA12;FGF3;MAX
Ras signaling pathwayPDGFD;FGF18;KSR2;PLCG2;FGF16;INS2;Kitl;GNG5;Pdgfa&Pdgfb
Rap signaling pathwayKLK1B4;FYB;LPAR3;RHOA;PIK3R1;PLCB2;ITGAL;PFN3;PDGFC
PIK-Akt signaling pathwaySGK3;RPS6KB1;IL7;FGF20;G6PC2;GNB4;IFNA6;OSMR;ANGPT4
Adherens junctionACTN2B;MAPK3;RHOA;CREBBP;RHOAA;MET;SMAD3A;RAC1A;PTPRJA
Signaling pathways regulating pluripotency of stem cellsID4;WNT9B;FZD9;TCF3;MAPK11;BMI1;SMAD1;WNT7B;TBX3
Regulation of actin cytoskeletonMAP2K2B;ACTB;MYL2B;MYH10;PFN2L;PIP5K1AA;RAC1A;VAV3B;FGF10A
Pathways in cancerRUNX1T1;HDAC1;STK36;PLCB3;PLEKHG5;STAT1;FN1;GNG13;AGTR1A
Proteoglycans in cancerIGF1R;FGF2;WNT9A;FASLG;PAK1;EZR;ITGB1;SMO;TWIST1
Prostate cancerSPRY1;GSK3B;CCNE1;MAP2K2;PDGFRA;NOXA1;IGF1R;IGF1;GSTP1
MelanomaBAD;PIK3CA;IGF1R;PIK3CD;RAF1;PIK3R3;MAPK1;IGF1;TRP53
Central carbon metabolism in cancerNTRK3;FGFR1;PKM;PGAM2;HK2;PIK3CB;TRP53;PIK3R1;HRAS

FGFR1 has several biochemical functions, for example, ATP binding, cell adhesion molecule binding, fibroblast growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGFR1 itself. We selected most functions FGFR1 had, and list some proteins which have the same functions with FGFR1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingSRPK1;JAK1;PKN3;PSKH2;NAV2;PL10;MAP3K1;PAICS;BCS1L
cell adhesion molecule bindingSMAGP;CADM3;PVRL1B;CADM1;SDCBP;FGFR1;DSG2;PTBP3;LILRB2
fibroblast growth factor bindingGPC1;KLB;FGFBP1;FGFR1;CXCL13;THBS1;TGFBR3;FGFBP3;S100A13
fibroblast growth factor-activated receptor activityFGFR1A;FGFR3;FGFR4;FGFR2;FGFR1B;FGFRL1;FGFR1
glycoprotein bindingPIP;HSPA5;BMPR1A;FLNA;Itgam&Itgb2;CD4;DNAJA2;CNTN2;FGFR1
heparin bindingPOSTN;NRP2;SFRP1;RSPO3;FGF10;RSPO2;LIPC;CCL2;PTN
identical protein bindingLECT2;RIPK3;MCM10;GCC2;TRIM5;GBP1;DHX8;PRMT1;NONO
protein bindingCOPS7B;SIN3B;BCKDK;CLPB;MLLT10;LNX2B;SLC30A1;HTR1A;WASF2
protein complex bindingRRAS;ANKRD32;HSPD1;GRIN2A;EP300;LAMB3;CCNE1;KLHL8;MLC1
protein homodimerization activityNUDT21;DMRTC2;ODZ4;DDX1;VAPB;Fzd4;PDGFB;IKZF2;DARS2
protein tyrosine kinase activityTYK2;ZAP70;DSTYK;SHC1;YES1;DYRK3;BMX;FGFR3;FGFR2

FGFR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGFR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGFR1.

PLCG1; HTR1A; FGF2

Gene Family

Cytokines

Research Area

Related articles

Stachowiak, MK; Birkaya, B; et al. "Nuclear FGF Receptor-1 and CREB Binding Protein: An Integrative Signaling Module". JOURNAL OF CELLULAR PHYSIOLOGY 230:989-1002(2015).
Ambrosini, S; Sarchielli, E; et al. FIBROBLAST GROWTH FACTOR AND ENDOTHELIN-1 RECEPTORS MEDIATE THE RESPONSE OF HUMAN STRIATAL PRECURSOR CELLS TO HYPOXIA. NEUROSCIENCE 289:123-133(2015).
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Q&As (5)

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How does DEFB103A interact with the human microbiome? 06/10/2022

DEFB103A plays a role in maintaining a balanced microbiome by exerting selective antimicrobial activity. Understanding this interaction is crucial for potential applications in microbiome-related disorders.

Can DEFB103A be used as a diagnostic marker for certain diseases? 05/01/2022

Research suggests that altered levels of DEFB103A expression may be associated with certain diseases. However, its specific use as a diagnostic marker requires further validation.

Are there any side effects or concerns associated with the therapeutic use of DEFB103A? 04/25/2022

While research is ongoing, potential side effects and concerns related to the therapeutic use of DEFB103A or its analogs need to be thoroughly investigated, including any possible immunogenicity.

How does DEFB103A contribute to the immune system? 02/08/2018

DEFB103A plays a crucial role in the innate immune system by acting as an antimicrobial peptide. It helps defend the body against a wide range of pathogens, including bacteria, viruses, and fungi.

What specific clinical conditions are associated with DEFB103A deficiency? 05/25/2017

DEFB103A deficiency has been linked to an increased susceptibility to various infections, particularly those affecting the skin and mucosal surfaces.

Customer Reviews (3)

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Reviews
05/01/2021

    FGFR1, a calcium-dependent phospholipid-binding protein, plays a crucial role in various cellular processes, making it a valuable tool for investigation.

    12/25/2018

      When combined with the support and quality assurance provided by the manufacturer, researchers can confidently utilize FGFR1 protein to unravel the intricate mechanisms underlying cellular processes, ultimately advancing scientific knowledge.

      07/24/2017

        The manufacturer can contribute to the research process by providing top-quality FGFR1 protein that meets rigorous standards of purity, stability, and reliability.

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