fgfr1
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  • Official Full Name
  • fibroblast growth factor receptor 1
  • Background
  • Fibroblast growth factor receptor 1 (FGFR1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome, and CD331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. FGFR1 has been shown to be associated with Pfeiffer syndrome.
  • Synonyms
  • FLG; FGFR1; fibroblast growth factor receptor 1; CEK; OGD; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; FLJ99988; bFGF-R-1; OTTHUMP00000190874; OTTHUMP00000190875; OTTHUMP00000190876; OTTHUMP00000190877; OTTHUMP00000190879; OTTHUMP00000190880; OTTHUMP00000190881; OTTHUMP00000190885; proto-oncogene c-Fgr; FMS-like tyrosine kinase 2; hydroxyaryl-protein kinase; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; H2; H3; H4; H5; Basic fibroblast growth factor receptor 1; N sam tyrosine kinase; Protein tyrosine kinase; Tyrosylprotein kinase; Hydroxyaryl protein kinase; Heparin binding growth factor receptor
Cat.#:FGFR1-384HTag:Strep
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR1 Protein, Strep-tagged
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Cat.#:FGFR1-715HTag:His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human FGFR1 Protein, His-tagged
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Cat.#:FGFR1-1133HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR1 Protein, His-tagged
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Cat.#:FGFR1-2054HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR1 Protein, MYC/DDK-tagged
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Cat.#:FGFR1-2056HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human FGFR1 Protein, His-tagged
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Cat.#:FGFR1-4121HTag:GST/His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human FGFR1 Protein, GST/His-tagged
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Cat.#:FGFR1-4122HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FGFR1 Protein
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Cat.#:FGFR1-4123HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FGFR1 Protein, GST-tagged
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Cat.#:FGFR1-5417HTag:his
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 1, His-tagged
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Cat.#:FGFR1-316HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 1, His-tagged
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Cat.#:FGFR1-01HTag:Fc
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 1, Fc-tagged
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Cat.#:FGFR1-111HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGFR1 protein, T7/His-tagged
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Cat.#:FGFR1-138HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR1, Fc-His tagged
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Cat.#:FGFR1-18HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR1, His-tagged
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Cat.#:FGFR1-207HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human FGFR1
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Cat.#:FGFR1-208HTag:DDK/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR1 protein, DDK/His-tagged
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Cat.#:FGFR1-210HTag:DDK/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR1 protein, DDK/His-tagged
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Cat.#:FGFR1-211HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human FGFR1 protein, His-tagged
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Cat.#:FGFR1-236HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human FGFR1 Protein, His & GST-tagged
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Cat.#:FGFR1-28834THTag:
Source (Host):Species:Human
Product nameRecombinant Human FGFR1
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Cat.#:FGFR1-28886THTag:
Source (Host):Species:Human
Product nameRecombinant Human FGFR1
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Cat.#:FGFR1-28890THTag:
Source (Host):Species:Human
Product nameRecombinant Human FGFR1
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Cat.#:FGFR1-312HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FGFR1, GST-tagged, Active
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Cat.#:FGFR1-45HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human FGFR1 protein, Flag-tagged, Biotinylated
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Cat.#:FGFR1-4843HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 1, GST-tagged
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Cat.#:FGFR1-485HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 1(IIIb)
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Cat.#:FGFR1-486HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 1(IIIc)
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Cat.#:FGFR1-487HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 1 Beta
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Cat.#:FGFR1-498HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR1, Fc Chimera
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Cat.#:FGFR1-605HTag:His
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human FGFR1, His-tagged, Biotinylated
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Cat.#:FGFR1-606HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human FGFR1, Fc-tagged, Biotinylated
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Cat.#:FGFR1-697HTag:Fc
Source (Host):NSO CellsSpecies:Human
Product nameRecombinant Human FGFR1 Protein, Fc Chimera
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Cat.#:FGFR1-8305HTag:
Source (Host):NS0Species:Human
Product nameRecombinant Human FGFR1
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Cat.#:Fgfr1-4015MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Fgfr1, Fc tagged
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Cat.#:Fgfr1-4016MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Fgfr1, His tagged
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Cat.#:Fgfr1-1800RTag:His/S
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Fgfr1 protein, His & S-tagged
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Cat.#:FGFR1-2338RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Fgfr1 protein, His/T7-tagged
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Cat.#:Fgfr1-2339RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Fgfr1 protein, His-tagged
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Cat.#:FGFR1-55CTag:Fc
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus FGFR1, Fc tagged
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Cat.#:FGFR1-67CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus FGFR1 protein, His-tagged
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Cat.#:FGFR1-1704RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey FGFR1 Protein, His-tagged
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Cat.#:FGFR1-66CTag:His
Source (Host):HEK293Species:Rhesus Macaque
Product nameRecombinant Rhesus FGFR1 protein, His-tagged
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Cat.#:FGFR1-8817CTag:Fc
Source (Host):HEK293Species:Rhesus Macaque
Product nameRecombinant Rhesus FGFR1 protein, Fc-tagged
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Cat.#:FGFR1-7059CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FGFR1
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Cat.#:FGFR1-1405HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FGFR1 (Active), GST-tagged
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Cat.#:FGFR1-2765HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR1 cell lysate
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Cat.#:FGFR1-476HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human FGFR1 cell lysate
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Cat.#:FGFR1-2133MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse FGFR1 cell lysate
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Cat.#:FGFR1-1171CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus FGFR1 cell lysate
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Cat.#:Kit-1557Tag:
Source (Host):Species:
Product nameU2OS FGFR1 Bioassay Kit
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Cat.#:Kit-1590Tag:
Source (Host):Species:
Product nameFGFR1 Functional Assay Kit
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Involved Pathway

FGFR1 involved in several pathways and played different roles in them. We selected most pathways FGFR1 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGFR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
RELA; PPP3CC; CACNA1G; MAX; NR4A1; ATF4; GRB2; PTPN7; CACNG1; RASGRP3
Ras signaling pathway
HRAS; ANGPT4; RIN1; PGF; GRIN2B; RALBP1; RASAL2; CSF1; SHC4; RAB5C
Rap signaling pathway
RAP1GAP; SKAP1; FGFR3; GNAI2; FLT1; CALM2; MRAS; FGF22; FGF16; GNAI1
PIK-Akt signaling pathway
BCL2; CRTC2; TLR2; CCNE1; PIK3R5; IFNAR1; STK11; PCK1; PDPK1; PDGFB
Adherens junction
LMO7; EP300; CSNK2A1; PVRL1B; VCL; TGFBR1B; Fert2; RAC3B; ACTN3A; PTPN1
Signaling pathways regulating pluripotency of stem cells
IGF1R; HESX1; PIK3R5; INHBB; WNT6; ACVR1C; MYF5; MAPK3; ZIC3; PIK3CB
Regulation of actin cytoskeleton
ABI2A; WASL; INSRR; MYH10; PIK3R3; GSNA; MYL7; ARPC5B; PIK3CA; CDC42L2
Pathways in cancer
CXCL12; GNG2; WNT3A; PIK3CG; SMAD4; GNAI1; RASGRP3; STK4; MAPK1; TGFBR2
Proteoglycans in cancer
PLAUR; MAP2K1; Ctsl; CAMK2A; WNT9B; PTPN6; PIK3CB; MAPK12; ARHGEF12; STAT3
Prostate cancer
IGF1R; ACTL6B; CCND1; CCNE1; HSP90AA1; NKX3-1; INSRR; PDGFC; MDM2; MAPK1
Melanoma
RB1; Pdgfa&Pdgfb; FGF4; AKT2; FGF7; FGF5; IGF1R; FGF6; FGF12; MAPK1
Central carbon metabolism in cancer
HK3; PDHA1; HK1; PIK3CB; HKDC1; ERBB2; TRP53; PKM2; G6PD; SLC1A5

Protein Function

FGFR1 has several biochemical functions, for example, ATP binding, cell adhesion molecule binding, fibroblast growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGFR1 itself. We selected most functions FGFR1 had, and list some proteins which have the same functions with FGFR1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PI4KB; ATP9A; TTK; GUCY2C; MAP2K1; STRADB; ERBB3B; CCT6A; PAK3; ABCF2
Function cell adhesion molecule binding
Related Protein CADM2A; VCAM1; CDH1; DSP; ITGB3; FGG; Fert2; CADM1B; PVRL2L; NLGN3
Function fibroblast growth factor binding
Related Protein CEP57; GLG1; GPC1; FGFR2; FGFBP1; FGFRL1; FGFR4; THBS1; CXCL13; FGFR1A
Function fibroblast growth factor-activated receptor activity
Related Protein FGFR1A; FGFR1; FGFR3; FGFR1B; FGFR2; FGFRL1; FGFR4
Function glycoprotein binding
Related Protein TFRC; LACRT; CSNK1D; SERPINA1E; BMPR1B; F7; ACE2; BMPR1A; STX1A; CALR
Function heparin binding
Related Protein APOB; Itgam&Itgb2; FN1; POSTN; FGFBP3; PF4; SERPIND1; SERPINE2; MDK; ITGAM
Function identical protein binding
Related Protein NPR2; GBP5; GOT1; GUCY2E; UBQLN1; CLDN20; RALYL; RABAC1; CBLL1; SNRNP200
Function protein binding
Related Protein PRKAR2A; CXCR2; TIMP2; HBA2; SNCG; NRL; C1S; GPRIN2; TRMT61B; SGPL1
Function protein complex binding
Related Protein SKIL; CDK2; C8G; ST13; CD2AP; DLG4; FADD; PPFIA2; NR0B2; RBM10
Function protein homodimerization activity
Related Protein PLEK; UGT1A3; RASGRP1; PYGL; TSG101; PVR; PDGFC; CEBPA; RNF40; JUP
Function protein tyrosine kinase activity
Related Protein RET; EPHB4A; ERBB3A; EPHA4B; Aatk; TTK; ERBB4; INSRA; CSK; YES1

Interacting Protein

FGFR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGFR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGFR1.
PLCG1; HTR1A; FGF2

FGFR1 Related Articles

Stachowiak, MK; Birkaya, B; et al. "Nuclear FGF Receptor-1 and CREB Binding Protein: An Integrative Signaling Module". JOURNAL OF CELLULAR PHYSIOLOGY 230:989-1002(2015).
Ambrosini, S; Sarchielli, E; et al. FIBROBLAST GROWTH FACTOR AND ENDOTHELIN-1 RECEPTORS MEDIATE THE RESPONSE OF HUMAN STRIATAL PRECURSOR CELLS TO HYPOXIA. NEUROSCIENCE 289:123-133(2015).

FGFR1 Related Gene Family

Cytokines