Recombinant Human Fms-Related Tyrosine Kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), GST-tagged
Cat.No. : | FLT1-1015H |
Product Overview : | Recombinant human FLT1 (784-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
- Download
Cat. No. : | FLT1-1015H |
Description : | FLT1, also known as fms-like tyrosine kinase 1, is a member of the VEGFR family and is related to the oncogene ROS. The tyrosine kinase activity of FLT1 has been shown to play a key role in control of cell proliferation and differentiation. FLT1 is a receptor for vascular endothelial growth factor (VEGF) and it has been observed that the ratio of FLT1 mRNA to VEGF mRNA correlates with tumor angiogenesis and prognosis in non-small cell lung cancers. In addition to the full-length receptor, FLT1 gene also encodes a soluble form of receptor due to alternative splicing. |
Applications : | Kinase Assay; Western Blot |
Molecular Weight : | 94 kDa |
Expression System : | Sf9 insect cells using baculovirus |
Species : | Human |
Form : | Recombinant protein stored in 50 mM Tris-HCl, PH 7.5, 150 mM NaCI, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol. |
Specific Activity : | 40 nmol/min/mg |
Purity : | >75% |
Concentration : | 0.1 ug/ul |
Sequences : | 784-end |
Storage : | Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Pathways : | Cytokine-cytokine receptor interaction; Endocytosis; Focal adhesion; Focal adhesion; Glypican 1 network; HIF-2-alpha transcription factor network; Id Signaling Pathway; Neurophilin interactions with VEGF and VEGFR; Rheumatoid arthritis; S1P3 pathway; Signaling by VEGF; Signaling events mediated by VEGFR1 and VEGFR2; VEGF binds to VEGFR leading to receptor dimerization; VEGF ligand-receptor interactions; VEGFR1 specific signals |
Protein length : | 784-end |
Gene Name : | FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) [ Homo sapiens ] |
Official Symbol : | FLT1 |
Synonyms : | FLT1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); FLT; VEGFR1; vascular endothelial growth factor receptor 1; FLT-1; VEGFR-1; OTTHUMP00000018183; fms-like tyrosine kinase 1; tyrosine-protein kinase FRT; tyrosine-protein kinase receptor FLT; vascular permeability factor receptor |
Gene ID : | 2321 |
mRNA Refseq : | NM_002019 |
Protein Refseq : | NP_002010 |
MIM : | 165070 |
UniProt ID : | P17948 |
Chromosome Location : | 13q12 |
Function : | ATP binding; growth factor binding; identical protein binding; nucleotide binding; receptor activity; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor-activated receptor activity |
Products Types
◆ Recombinant Protein | ||
Flt1-1785M | Active Recombinant Mouse Flt1 Protein, Fc-tagged | +Inquiry |
FLT1-4366H | Recombinant Human FLT1 Protein | +Inquiry |
FLT1-4367H | Active Recombinant Human FLT1 Protein, GST-tagged | +Inquiry |
FLT1-01H | Active Recombinant Human FLT1 Protein (27-328aa), C-hIgG-tagged | +Inquiry |
FLT1-133H | Active Recombinant Human FLT1 Protein (27-328aa), C-hIgG tagged | +Inquiry |
◆ Lysates | ||
FLT1-1207RCL | Recombinant Rat FLT1 cell lysate | +Inquiry |
FLT1-1909HCL | Recombinant Human FLT1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewthe FLT1 protein is an excellent choice for researchers due to its high quality, reliability, and the comprehensive technical support provided by the manufacturer.
The manufacturer of FLT1 protein provides excellent technical support, ensuring that researchers receive prompt assistance and guidance when encountering any challenges or difficulties.
Researchers can confidently incorporate FLT1 protein into their experiments, knowing that they have access to a reliable resource that will meet their experimental needs effectively.
Q&As (5)
Ask a questionElevated levels of soluble FLT1 have been associated with preeclampsia, a pregnancy complication. Soluble FLT1 acts as a decoy receptor, reducing the bioavailability of VEGF and contributing to vascular dysfunction.
FLT1 has been implicated in retinal diseases like diabetic retinopathy, where abnormal blood vessel growth can lead to vision impairment. Inhibiting FLT1 may help regulate angiogenesis in such conditions.
FLT1 expression is regulated by various factors, including VEGF itself, as well as hypoxia and inflammation. These factors influence the balance of angiogenic signaling.
Yes, elevated levels of soluble FLT1 have been investigated as potential biomarkers for conditions like preeclampsia, cancer, and certain cardiovascular diseases.
Yes, targeting FLT1 is a strategy for anti-angiogenic therapy. Inhibiting FLT1 can impede blood vessel formation, limiting the blood supply to tumors and potentially slowing their growth.
Ask a Question for All FLT1 Products
Required fields are marked with *
My Review for All FLT1 Products
Required fields are marked with *
Inquiry Basket