Recombinant Human Fms-Related Tyrosine Kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), GST-tagged

Cat.No. : FLT1-1015H
Product Overview : Recombinant human FLT1 (784-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
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Cat. No. : FLT1-1015H
Description : FLT1, also known as fms-like tyrosine kinase 1, is a member of the VEGFR family and is related to the oncogene ROS. The tyrosine kinase activity of FLT1 has been shown to play a key role in control of cell proliferation and differentiation. FLT1 is a receptor for vascular endothelial growth factor (VEGF) and it has been observed that the ratio of FLT1 mRNA to VEGF mRNA correlates with tumor angiogenesis and prognosis in non-small cell lung cancers. In addition to the full-length receptor, FLT1 gene also encodes a soluble form of receptor due to alternative splicing.
Applications : Kinase Assay; Western Blot
Molecular Weight : 94 kDa
Expression System : Sf9 insect cells using baculovirus
Species : Human
Form : Recombinant protein stored in 50 mM Tris-HCl, PH 7.5, 150 mM NaCI, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Specific Activity : 40 nmol/min/mg
Purity : >75%
Concentration : 0.1 ug/ul
Sequences : 784-end
Storage : Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : Cytokine-cytokine receptor interaction; Endocytosis; Focal adhesion; Focal adhesion; Glypican 1 network; HIF-2-alpha transcription factor network; Id Signaling Pathway; Neurophilin interactions with VEGF and VEGFR; Rheumatoid arthritis; S1P3 pathway; Signaling by VEGF; Signaling events mediated by VEGFR1 and VEGFR2; VEGF binds to VEGFR leading to receptor dimerization; VEGF ligand-receptor interactions; VEGFR1 specific signals
Gene Name : FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) [ Homo sapiens ]
Official Symbol : FLT1
Synonyms : FLT1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); FLT; VEGFR1; vascular endothelial growth factor receptor 1; FLT-1; VEGFR-1; OTTHUMP00000018183; fms-like tyrosine kinase 1; tyrosine-protein kinase FRT; tyrosine-protein kinase receptor FLT; vascular permeability factor receptor
Gene ID : 2321
mRNA Refseq : NM_002019
Protein Refseq : NP_002010
MIM : 165070
UniProt ID : P17948
Chromosome Location : 13q12
Function : ATP binding; growth factor binding; identical protein binding; nucleotide binding; receptor activity; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor-activated receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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07/08/2019

    the FLT1 protein is an excellent choice for researchers due to its high quality, reliability, and the comprehensive technical support provided by the manufacturer.

    07/17/2018

      The manufacturer of FLT1 protein provides excellent technical support, ensuring that researchers receive prompt assistance and guidance when encountering any challenges or difficulties.

      05/27/2016

        Researchers can confidently incorporate FLT1 protein into their experiments, knowing that they have access to a reliable resource that will meet their experimental needs effectively.

        Q&As (5)

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        How is FLT1 linked to preeclampsia in pregnancy? 08/26/2021

        Elevated levels of soluble FLT1 have been associated with preeclampsia, a pregnancy complication. Soluble FLT1 acts as a decoy receptor, reducing the bioavailability of VEGF and contributing to vascular dysfunction.

        How does FLT1 contribute to retinal diseases such as diabetic retinopathy? 07/23/2021

        FLT1 has been implicated in retinal diseases like diabetic retinopathy, where abnormal blood vessel growth can lead to vision impairment. Inhibiting FLT1 may help regulate angiogenesis in such conditions.

        How is FLT1 expression regulated in the human body? 12/09/2020

        FLT1 expression is regulated by various factors, including VEGF itself, as well as hypoxia and inflammation. These factors influence the balance of angiogenic signaling.

        Can FLT1 be a biomarker for certain diseases? 12/01/2018

        Yes, elevated levels of soluble FLT1 have been investigated as potential biomarkers for conditions like preeclampsia, cancer, and certain cardiovascular diseases.

        Can FLT1 be targeted for anti-angiogenic therapy? 09/20/2017

        Yes, targeting FLT1 is a strategy for anti-angiogenic therapy. Inhibiting FLT1 can impede blood vessel formation, limiting the blood supply to tumors and potentially slowing their growth.

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