FLT1

  • Official Full Name

    fms-related tyrosine kinase 1

  • Overview

    This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]
  • Synonyms

    FLT1; fms-related tyrosine kinase 1; FLT; FLT-1; VEGFR1; VEGFR-1; vascular endothelial growth factor receptor 1; fms-like tyrosine kinase 1; tyrosine-protein kinase FRT; tyrosine-protein kinase receptor FLT; vascular permeability factor receptor; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Therapeutic Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Mouse
  • Pig
  • Rat
  • Rhesus macaque
  • Zebrafish
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Human Cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • 8X His(C
  • ter)
  • C
  • Fc
  • hIgG
  • His
  • DDK
  • Fc Chimera
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|Avi
  • His|GST
  • His|T7
  • mFc
  • Mouse|IgG2a|Fc
  • Myc
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FLT1-1407H Active Recombinant Human FLT1, GST-tagged Sf9 Insect Cell GST 784 aa-end
Human FLT1-12H Active Recombinant Human FLT1 protein Insect Cell N/A
Human FLT1-241H Active Recombinant Human FLT1, Fc Chimera Sf21 Insect Cell Fc Chimera
Human FLT1-615H Active Recombinant Human FLT1, Fc-tagged, Biotinylated Human Cell Fc
Human FLT1-616H Active Recombinant Human FLT1, Fc-tagged Human Cell Fc
Human FLT1-89H Active Recombinant Human FLT1(783-end) Protein, N-GST-tagged Sf21 GST 783-end
Human FLT1-3809H Active Recombinant Human FLT1 protein, His-tagged HEK293 His Met1-Ile328
Human FLT1-938H Recombinant Human FLT1 Protein, DDK-tagged Sf9 Insect Cell DDK
Human FLT1-190H Active Recombinant Human FLT1 protein, Fc-tagged HEK293 Fc Met1-Ile328
Human FLT1-530H Active Recombinant Human FLT1 protein, His-tagged HEK293 His Met1-Ile328
Human FLT1-31714TH Recombinant Human FLT1, His-tagged E.coli His
Human FLT1-31709TH Recombinant Human FLT1 N/A
Human FLT1-31713TH Recombinant Human FLT1, His-tagged His
Human FLT1-318H Recombinant Human FLT1, GST-tagged, Active Sf9 Insect Cell GST
Human FLT1-544H Recombinant Human FLT1, His-tagged Sf9 Insect Cell His
Human FLT1-31711TH Recombinant Human FLT1 N/A
Human FLT1-79H Recombinant Human Fms-related Tyrosine Kinase 1, 4 Domains Insect Cell N/A
Human FLT1-32H Recombinant Human FLT1, His-tagged Human Cell His
Human FLT1-31708TH Recombinant Human FLT1, His-tagged His
Human FLT1-7650H Recombinant Human FLT1 N/A
Human FLT1-81H Recombinant Human Fms-related Tyrosine Kinase 1, 5 Domains, Fc-tagged Insect Cell Fc
Human FLT1-1221H Recombinant Human Fms-Related Tyrosine Kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) Insect Cell N/A
Human FLT1-31710TH Recombinant Human FLT1, His-tagged His
Human FLT1-1015H Recombinant Human Fms-Related Tyrosine Kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), GST-tagged Sf9 Insect Cell GST
Human FLT1-979H Recombinant Human Fms-related Tyrosine Kinase 1, Fc Chimera Insect Cell Fc
Human FLT1-80H Recombinant Human Fms-related Tyrosine Kinase 1, 5 Domains Insect Cell N/A
Human FLT1-899H Recombinant Human Fms-Related Tyrosine Kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), His-tagged Human His
Human FLT1-82H Recombinant Human Fms-related Tyrosine Kinase 1, 6 Domains Insect Cell N/A
Human FLT1-1222H Recombinant Human Fms-Related Tyrosine Kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), His-tagged Sf9 Insect Cell His
Human FLT1-78H Recombinant Human Fms-related Tyrosine Kinase 1, 3 Domains Insect Cell N/A
Human FLT1-1909HCL Recombinant Human FLT1 cell lysate Human Cell N/A
Human FLT1-4369H Recombinant Human FLT1 Protein, GST-tagged Wheat Germ GST
Human FLT1-24H Recombinant Human FLT1 Protein, His-tagged HEK293 His
Human FLT1 & KDR-P1006H Recombinant Human FLT1/KDR, Fc-tagged therapeutic protein CHO Fc
Human FLT1-3809HAF488 Recombinant Human FLT1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 741
Human FLT1-2341H Recombinant Human FLT1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human FLT1-1313H Recombinant Human FLT1 Protein (P801-L1158), Tag Free E.coli No tag P801-L1158
Human VEGFR1&VEGFR2-P019H Recombinant Human FLT1/VEGFR2, Fc-tagged therapeutic protein CHO Fc
Human FLT1-372H Recombinant Human FLT1 Protein, His-tagged E.coli N-His Ser27-Ile328
Human FLT1-310HB Recombinant Human FLT1 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi It contains Ser27-His687.
Human FLT1-1314H Recombinant Human FLT1 Protein (P801-L1158), His tagged E.coli His P801-L1158
Human VEGFR1&VEGFR2-P09H Recombinant Human FLT1/VEGFR2, Fc-tagged therapeutic protein Fc
Human FLT1-190HAF555 Recombinant Human FLT1 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 543
Human FLT1-3809HAF555 Recombinant Human FLT1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 741
Human FLT1-923H-B Recombinant Human FLT1 Protein Pre-coupled Magnetic Beads HEK293
Human FLT1-321H Recombinant Human FLT1 protein, His-Avi-tagged HEK293 His-Avi It contains Ser27-Asn756.
Human FLT1-3809HAF647 Recombinant Human FLT1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 741
Human FLT1-190HAF647 Recombinant Human FLT1 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 543
Human FLT1-133H Active Recombinant Human FLT1 Protein (27-328aa), C-hIgG tagged HEK293 C-hIgG 27-328aa
Human FLT1-5899H Recombinant Human FLT1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FLT1-3809HF Recombinant Human FLT1 Protein, His-tagged, FITC conjugated HEK293 His 741
Human FLT1-190HF Recombinant Human FLT1 Protein, Fc-tagged, FITC conjugated HEK293 Fc 543
Human FLT1-95H Recombinant Human FLT1 Protein (ECD), 8X His-tagged(C-ter) HEK293 8X His(C-ter) Met1-Asn756
Human FLT1-190HAF488 Recombinant Human FLT1 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 543
Human FLT1-01H Active Recombinant Human FLT1 Protein (27-328aa), C-hIgG-tagged HEK293 C-hIgG 27-328aa
Human FLT1-1576HFL Recombinant Full Length Human FLT1 Protein, C-Flag-tagged Mammalian cells Flag
Human FLT1-923H Recombinant Human FLT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human FLT1-4366H Recombinant Human FLT1 Protein E.coli N/A
Human FLT1-3810H Active Recombinant Human FLT1 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
Human Flt1-0826H Active Recombinant Human Flt1 protein, His-tagged HEK293 His Ser27-Asn756
Human FLT1-4367H Active Recombinant Human FLT1 Protein, GST-tagged Insect Cell GST
Human FLT1-474H Recombinant Human FLT1 Protein, His-tagged HEK293 His 1338
Human FLT1-2804H Recombinant Human FLT1 Protein (Met1-Ile328), C-His tagged Mammalian cells C-His Met1-Ile328
Human FLT1-2805H Recombinant Human FLT1 Protein (Met1-Val232), C-Fc tagged Mammalian cells C-Fc Met1-Val232
Mouse Flt1-1786M Active Recombinant Mouse Flt1 Protein, Fc-tagged Mammalian cells Fc Ser27-Glu759
Mouse Flt1-1785M Active Recombinant Mouse Flt1 Protein, Fc-tagged Mammalian cells Fc
Mouse FLT1-5927M Recombinant Mouse FLT1 Protein Mammalian Cell His
Mouse Flt1-1838M Recombinant Mouse Flt1 protein, His-tagged E.coli His Ser27~Val329
Mouse Flt1-7210M Active Recombinant Mouse Flt1 Protein, Fc-tagged Insect Cell Fc
Mouse Flt1-8114M Recombinant Mouse Flt1 protein, mFc-tagged HEK293 mFc AA Tyr 23 - Glu 759
Mouse Flt1-49M Recombinant Mouse Flt1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Flt1-12M Recombinant Mouse Flt1 protein, His-tagged HEK293 His Met1-Glu759
Mouse Flt1-49M-B Recombinant Mouse Flt1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Flt1-3044M Recombinant Mouse Flt1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Flt1-1840R Recombinant Rat Flt1 protein, His-tagged E.coli His Ser303~Val524
Rat Flt1-8712R Active Recombinant Rat Flt1 protein, His-tagged HEK293 His Met1-Glu758
Rat FLT1-2364R Recombinant Rat FLT1 Protein Mammalian Cell His
Rat Flt1-1841R Recombinant Rat Flt1 protein, His & T7-tagged E.coli His/T7 Leu18~Leu308 (Accession # P53767)
Rat FLT1-1207RCL Recombinant Rat FLT1 cell lysate Human Cell N/A
Rat FLT1-2020R Recombinant Rat FLT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Flt1-8712RAF555 Recombinant Rat Flt1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 747
Rat Flt1-8712RAF488 Recombinant Rat Flt1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 747
Rat FLT1-2020R-B Recombinant Rat FLT1 Protein Pre-coupled Magnetic Beads HEK293
Rat Flt1-8712RF Recombinant Rat Flt1 Protein, His-tagged, FITC conjugated HEK293 His 747
Rat Flt1-8712RAF647 Recombinant Rat Flt1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 747
Rhesus macaque FLT1-379R Recombinant Rhesus macaque FLT1 protein, Mouse IgG2a Fc-tagged, low endotoxin HEK293 Mouse/IgG2a/Fc 730
Zebrafish FLT1-2299Z Recombinant Zebrafish FLT1 Mammalian Cell His
Pig FLT1-1839P Recombinant Pig FLT1 protein, His & GST-tagged E.coli His/GST Pro167~Ala424
Chicken FLT1-5825C Recombinant Chicken FLT1 Mammalian Cell His
  • Background
  • Quality Guarantee
  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

What is flt1 protein?

FLT1 stands for FMS-like tyrosine kinase 1, also known as vascular endothelial growth factor receptor 1 (VEGFR1). It is a type I transmembrane receptor tyrosine kinase that binds VEGF-A, VEGF-B, and PlGF ligands with high affinity. FLT1 plays a key role in blood vessel formation (vasculogenesis) and maturation (angiogenesis) during embryonic development and tissue remodeling.

What is the function of flt1 protein?

Angiogenesis: FLT1 signaling promotes endothelial cell proliferation, migration and survival, key steps in sprouting angiogenesis and blood vessel branch formation.

Vasculogenesis: During embryonic development, FLT1 helps in de novo blood vessel formation through vasculogenesis, the process of assembling endothelial progenitor cells into primitive vessels.

Vascular permeability: FLT1 activation increases permeability of endothelial cell junctions, allowing plasma components and cells to exit vessels during angiogenesis.

Flt1 related signaling pathway

PI3K-Akt pathway: FLT1 dimerization leads to recruitment and phosphorylation of PI3K, which activates PDK1 and Akt. Akt promotes cell survival, growth and metabolism.

PLCγ pathway: PLCγ is activated by FLT1 and generates IP3 and DAG. IP3 causes calcium release while DAG activates PKC. This regulates cell migration, survival and permeability.

Ras-Raf-MEK-ERK pathway: FLT1 activates GRB2/SOS complex which activates Ras. This triggers the Raf-MEK-ERK cascade, promoting cell proliferation and survival.

SRC family kinases: FLT1 recruits and activates c-SRC and other SRC kinases. They induce downstream signaling regulating migration, sprouting and permeability.

Focal adhesion kinase (FAK) pathway: FLT1 induces FAK phosphorylation which triggers reorganization of actin cytoskeleton and focal adhesions, controlling cell motility.

FLT1 Related Diseases

  •  Preeclampsia: Abnormal placentation and reduced FLT1 signaling is implicated in the hypertensive disorder of pregnancy.
  •  Cancer: Overexpression of FLT1/VEGF drives angiogenesis, invasion and metastasis in many tumors like breast and colon cancers.
  •  Macular degeneration: Genetic risk factors exist involving FLT1 pathway in age-related degeneration of the eye's macula.
  •  Atherosclerosis: FLT1 likely influences endothelial dysfunction and lesion formation in the artery-narrowing disease.
  •  Cancer therapy: FLT1 inhibitors/antagonists are being developed to block tumor angiogenesis and growth.
  •  Regenerative medicine: Delivery of FLT1 promotes revascularization of tissues/organs in transplants and repairs.
  •  Wound healing: FLT1 enhances healing by inducing neovascularization of damaged dermal and epithelial tissues.
  •  Ischemic disease treatment: Stimulating FLT1 signaling aids reperfusion of blood to ischemic tissues in heart attacks and strokes.
  •  Diabetic ulcer/foot care: Angiogenesis induced via FLT1 improves healing of non-healing ulcers in diabetes.
  •  Cancer therapy: FLT1 inhibitors/antagonists are being developed to block tumor angiogenesis and growth.
  •  Regenerative medicine: Delivery of FLT1 promotes revascularization of tissues/organs in transplants and repairs.
  •  Wound healing: FLT1 enhances healing by inducing neovascularization of damaged dermal and epithelial tissues.
  •  Ischemic disease treatment: Stimulating FLT1 signaling aids reperfusion of blood to ischemic tissues in heart attacks and strokes.
  •  Diabetic ulcer/foot care: Angiogenesis induced via FLT1 improves healing of non-healing ulcers in diabetes.

High Purity

SDS-PAGE Flt1-1840R.jpg

Fig1. SDS-PAGE (Cat. No.: Flt1-1840R)

High Bioactivity & Detection Sensitivity

Flt1 bioactivity.jpg

Fig2. The protein has a predicted MW of 85. 1 kDa. Due to glycosylation, the protein migrates to 100- 120KDa based on Bis-Tris PAGE result.

Quantification of endothelial cell numbers in four consecutive segmental vessel.jpg

(Janna Krueger, 2011)

Fig3. Quantification of endothelial cell numbers in four consecutive segmental vessel (ISV) – dorsal longitudinal anastomotic vessel (DLAV) loops reveals an increase in flt1 morphants.

locations of sequencing primers for flt1 gene.jpg

(Jee Yeon Kim, 2015)

Fig4. Closed bars, exon 1 region for each gene; arrows, translation start site; open bars, the region targeted for pyrosequencing; black segments within open bars, locations of sequencing primers for each gene.

FLT1 involved in several pathways and played different roles in them. We selected most pathways FLT1 participated on our site, such as Ras signaling pathway, Rap signaling pathway, Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with FLT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ras signaling pathwayFGF22;RASAL2;FLT4;PRKACB;PLA2G12B;PIK3R3;CDC42;NGFR;FGF10
Rap signaling pathwayPLCB2;LPAR4;PDGFD;PRKD2;FGF16;ITGB2;RHOA;FGF4;ITGAM
Cytokine-cytokine receptor interactionIFNAR1;GH1;CX3CR1;CCL4L2;VEGFAA;PLEKHO2;Ccl27a;KDRL;IL6ST
HIF- signaling pathwayLTBR;TIMP1;IFNG;VHL;MAP2K1;ARNT;CAMK2A;STAT3;TLR4
EndocytosisHLA-G;WASLA;RET;CDC42L2;GRK5;SH3GL1;RAB35B;AGAP2;RAB11FIP4A
PIK-Akt signaling pathwayYWHAG;CCND1;AKT1;Ifna11;SGK3;FGF21;VTN;IL7R;FGFR3
Focal adhesionMYLK;BCL2A;FIGF;AKT1;HRASB;PTENA;DOCK1;ITGB7;PARVA
Transcriptional misregulation in cancerERG;HOXA9;ETV1;JMJD1C;SIX1;TRAF1;HIST2H3C1;FOXO1;MLF1
Rheumatoid arthritisHLA-DOB;TNFRSF11A;IL1A;IL-8;CD86;TLR4;FOS;ATP6V1H;ATP6V0A1

FLT1 has several biochemical functions, for example, ATP binding, VEGF-A-activated receptor activity, VEGF-B-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FLT1 itself. We selected most functions FLT1 had, and list some proteins which have the same functions with FLT1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingATP2C1;PKDCC;HIPK1;NTRK3;CLK2B;NMRK2;MYH9A;ATP1A1A.1;TK2
VEGF-A-activated receptor activity
VEGF-B-activated receptor activity
growth factor bindingHTRA1B;A2M;TEK;GHRHR;GHR;RPL37;BMPR2;FLT4;FLT1
placental growth factor-activated receptor activity
protein bindingGPATCH8;ALKBH4;PCMT1;AHSA1;MED23;RNF175;NRG4;HTATIP2;NUP85
transmembrane receptor protein tyrosine kinase activityINSRA;FGFR1B;DDR1;INSRB;EPHA4A;IGF1RB;RET;ALK;CSF1RA
vascular endothelial growth factor-activated receptor activityNRP1;PDGFRA;FLT4;FLT3;KDR;NRP1B;NRP2;FLT1;NRP1A

FLT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FLT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FLT1.

VEGFA; PTPRJ; PGF; PIK3R1; VEGFA; CRKL

Research Area

Related articles

Ahmadova, Z; Yagublu, V; et al. Fluorescent Resonance Energy Transfer Imaging of VEGFR Dimerization. ANTICANCER RESEARCH 34:2123-2133(2014).
Suspitsin, EN; Kashyap, A; et al. Evidence for angiogenesis-independent contribution of VEGFR1 (FLT1) in gastric cancer recurrence. MEDICAL ONCOLOGY 30:-(2013).
  • Q&As
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Q&As (5)

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How is FLT1 linked to preeclampsia in pregnancy? 08/26/2021

Elevated levels of soluble FLT1 have been associated with preeclampsia, a pregnancy complication. Soluble FLT1 acts as a decoy receptor, reducing the bioavailability of VEGF and contributing to vascular dysfunction.

How does FLT1 contribute to retinal diseases such as diabetic retinopathy? 07/23/2021

FLT1 has been implicated in retinal diseases like diabetic retinopathy, where abnormal blood vessel growth can lead to vision impairment. Inhibiting FLT1 may help regulate angiogenesis in such conditions.

How is FLT1 expression regulated in the human body? 12/09/2020

FLT1 expression is regulated by various factors, including VEGF itself, as well as hypoxia and inflammation. These factors influence the balance of angiogenic signaling.

Can FLT1 be a biomarker for certain diseases? 12/01/2018

Yes, elevated levels of soluble FLT1 have been investigated as potential biomarkers for conditions like preeclampsia, cancer, and certain cardiovascular diseases.

Can FLT1 be targeted for anti-angiogenic therapy? 09/20/2017

Yes, targeting FLT1 is a strategy for anti-angiogenic therapy. Inhibiting FLT1 can impede blood vessel formation, limiting the blood supply to tumors and potentially slowing their growth.

Customer Reviews (3)

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Reviews
07/08/2019

    the FLT1 protein is an excellent choice for researchers due to its high quality, reliability, and the comprehensive technical support provided by the manufacturer.

    07/17/2018

      The manufacturer of FLT1 protein provides excellent technical support, ensuring that researchers receive prompt assistance and guidance when encountering any challenges or difficulties.

      05/27/2016

        Researchers can confidently incorporate FLT1 protein into their experiments, knowing that they have access to a reliable resource that will meet their experimental needs effectively.

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