This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]
FLT1 involved in several pathways and played different roles in them. We selected most pathways FLT1 participated on our site, such as Ras signaling pathway, Rap signaling pathway, Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with FLT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
FLT1 has several biochemical functions, for example, ATP binding, VEGF-A-activated receptor activity, VEGF-B-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FLT1 itself. We selected most functions FLT1 had, and list some proteins which have the same functions with FLT1. You can find most of the proteins on our site.
FLT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FLT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FLT1.
VEGFA; PTPRJ; PGF; PIK3R1; VEGFA; CRKL
Ahmadova, Z; Yagublu, V; et al. Fluorescent Resonance Energy Transfer Imaging of VEGFR Dimerization. ANTICANCER RESEARCH 34:2123-2133(2014).
Suspitsin, EN; Kashyap, A; et al. Evidence for angiogenesis-independent contribution of VEGFR1 (FLT1) in gastric cancer recurrence. MEDICAL ONCOLOGY 30:-(2013).
How is FLT1 linked to preeclampsia in pregnancy?
Elevated levels of soluble FLT1 have been associated with preeclampsia, a pregnancy complication. Soluble FLT1 acts as a decoy receptor, reducing the bioavailability of VEGF and contributing to vascular dysfunction.
How does FLT1 contribute to retinal diseases such as diabetic retinopathy?
FLT1 has been implicated in retinal diseases like diabetic retinopathy, where abnormal blood vessel growth can lead to vision impairment. Inhibiting FLT1 may help regulate angiogenesis in such conditions.
How is FLT1 expression regulated in the human body?
FLT1 expression is regulated by various factors, including VEGF itself, as well as hypoxia and inflammation. These factors influence the balance of angiogenic signaling.
Can FLT1 be a biomarker for certain diseases?
Yes, elevated levels of soluble FLT1 have been investigated as potential biomarkers for conditions like preeclampsia, cancer, and certain cardiovascular diseases.
Can FLT1 be targeted for anti-angiogenic therapy?
Yes, targeting FLT1 is a strategy for anti-angiogenic therapy. Inhibiting FLT1 can impede blood vessel formation, limiting the blood supply to tumors and potentially slowing their growth.