Recombinant Human FTO Protein, His-tagged

• Cat.No.: FTO-025H
• Product Overview: Recombinant N-terminal histidine-tagged human FTO protein (32-505) was purified from E. coli.

Specification

• Description: This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: 56.68 kDa
• Protein length: 32-505
• Purity: ≥80% as determined by SDS-PAGE
• Stability: ≥ 6 months
• Storage: At -80 centigrade.
• Storage Buffer: 50 mM HEPES, pH 8.0, with 150 mM sodium choride and 10% glycerol

Gene Information

• Gene Name: FTO FTO alpha-ketoglutarate dependent dioxygenase [ Homo sapiens (human) ]
• Official Symbol: FTO
• Synonyms: FTO; FTO alpha-ketoglutarate dependent dioxygenase; GDFD; ALKBH9; BMIQ14; alpha-ketoglutarate-dependent dioxygenase FTO; AlkB homolog 9; U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO; fat mass and obesity associated; fat mass and obesity-associated protein; m6A(m)-demethylase FTO; mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; mRNA N(6)-methyladenosine demethylase FTO; tRNA N1-methyl adenine demethylase FTO; EC 1.14.11.53
• Gene ID: 79068
• mRNA Refseq: NM_001080432
• Protein Refseq: NP_001073901
• MIM: 610966
• UniProt ID: Q9C0B1