Recombinant Human GCK Protein, MYC/DDK-tagged

• Cat.No.: GCK-658H
• Product Overview: Recombinant Human GCK, transcript variant 1, fused with MYC/DDK tag at C-terminal was expressed in HEK293.

Specification

• Description: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 52 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: GCK glucokinase (hexokinase 4) [ Homo sapiens ]
• Official Symbol: GCK
• Synonyms: GCK; glucokinase (hexokinase 4); maturity onset diabetes of the young 2 , MODY2; glucokinase; HK4; HK IV; hexokinase-4; hexokinase-D; hexokinase type IV; hexokinase D, pancreatic isozyme; ATP:D-hexose 6-phosphotransferase; GK; GLK; HHF3; HKIV; HXKP; LGLK; MODY2; FGQTL3
• Gene ID: 2645
• mRNA Refseq: NM_000162
• Protein Refseq: NP_000153
• MIM: 138079
• UniProt ID: P35557