Recombinant Human GFER, His-SUMO-tagged
Cat.No. : | GFER-216H |
Product Overview : | Recombinant Human GFER /ALR MS Standard Protein, C13 and N15-labeled (GFER, Heavy Labeled) Met 81 - Asp 205 (Accession # NP_005253) was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain >99% incorporation eff |
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Description : | Growth factor, augmenter of liver regeneration (GFER) is also known as FAD-linked sulfhydryl oxidase ALR, which belongs to the Erv1/ALR family of proteins. This family can be found in higher and lower eukaryotes. There are two isoform of GFER: Isoform 1 and isoform 2. Isoform 2 missing 1 – 80 aa. Isoform 1 is mainly located in mitochondrion intermembrane space, while Isoform 1 is secreted to cytoplasm. Isoform 1 of GFER regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. The isoform 2 of GFER may act as an autocrine hepatotrophic growth factor promoting liver regeneration. |
Source : | HEK293 |
Species : | Human |
Tag : | His&SUMO |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization. |
Molecular Mass : | rh GFER, Heavy Labeled is fused with polyhistidine tag and SUMO tag at the N-terminus, and has a calculated MW of 27.3 kDa. The predicted N-terminus is Met 81. DTT-reduced Protein migrates as 33 kDa in SDS-PAGE .GFER, Heavy Labeled is labeled with [U- 13 |
Endotoxin : | Less than 1.0 EU per μg of the rh GFER, Heavy Labeled by the LAL method. |
Purity : | >80% as determined by SDS-PAGE. |
Storage : | Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC). |
Reconstitution : | See Certificate of Analysis for reconstitution instructions and specific concentrations. |
Protein length : | Met81-Asp205 |
Gene Name : | GFER growth factor, augmenter of liver regeneration [ Homo sapiens ] |
Official Symbol : | GFER |
Synonyms : | GFER; growth factor, augmenter of liver regeneration; growth factor, erv1 (S. cerevisiae) like (augmenter of liver regeneration); FAD-linked sulfhydryl oxidase ALR; ALR; ERV1; ERV1 homolog (S. cerevisiae); HERV1; HPO1; HPO2; HSS; ERV1 homolog; hepatopoietin protein; erv1-like growth factor; hepatic regenerative stimulation substance; HPO; |
Gene ID : | 2671 |
mRNA Refseq : | NM_005262 |
Protein Refseq : | NP_005253 |
MIM : | 600924 |
UniProt ID : | P55789 |
Chromosome Location : | 16p13.3-p13.12 |
Pathway : | Metabolism of proteins, organism-specific biosystem; Mitochondrial Protein Import, organism-specific biosystem; |
Function : | growth factor activity; oxidoreductase activity; protein binding; thiol oxidase activity; |
Products Types
◆ Recombinant Protein | ||
GFER-491H | Recombinant Human GFER Protein | +Inquiry |
GFER-4849H | Recombinant Human GFER Protein, GST-tagged | +Inquiry |
GFER-2165R | Recombinant Rat GFER Protein, His (Fc)-Avi-tagged | +Inquiry |
GFER-3536M | Recombinant Mouse GFER Protein, His (Fc)-Avi-tagged | +Inquiry |
GFER-1225R | Recombinant Rat GFER Protein, His-SUMO-tagged | +Inquiry |
◆ Lysates | ||
GFER-5954HCL | Recombinant Human GFER 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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