Recombinant Human GPC3 Protein, His\Avi-tagged
Cat.No. : | GPC3-186H |
Product Overview : | Biotinylated Recombinant Human Glypican-3 is produced by our Mammalian expression system and the target gene encoding Gln25-His559 is expressed with a 6His, Avi tag at the C-terminus. |
- Specification
- Gene Information
- Related Products
Description : | Glypican-3/GPC3 is a member of the glypican family. It belongs to the glypican family and is highly expressed in lung, liver, and kidney. It is a heparan sulfate proteoglycan, which is overexpressed in various neoplasms such as hepatocellular carcinoma, malignant melanoma, and testicular yolk sac tumor, and plays an important role in cell growth and differentiation. GPC3 function is tissue dependent. In some tissues, GPC3 acts as a tumor suppressor gene, whereas in others, it acts as an oncofetal protein. GPC3 is a reliable marker for hepatocellular carcinoma. The sensitivity and specificity exceeds both alpha-fetoprotein and hepatocyte-paraffin1. GPC3 immunohistochemistry can aid in the differentiation of testicular germ cell tumors, being expressed in all yolk sac tumors but not in seminomas. GPC3 expression has also been identified in some squamous cell carcinomas of the lung and clear cell carcinomas of the ovary. Glypican-3 is currently regarded as a tumor marker and potential target for immunotherapy. |
Source : | Human Cells |
Species : | Human |
Tag : | His\Avi |
Form : | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
AA Sequence : | Gln25-His559 |
Endotoxin : | Less than 0.1 ng/ug (1 EU/ug). |
Shipping : | Ambient |
Gene Name : | GPC3 glypican 3 [ Homo sapiens (human) ] |
Official Symbol : | GPC3 |
Synonyms : | Sialic acid-binding Ig-like lectin 9; Siglec-9; CDw329; Protein FOAP-9; SGB; DGSX; MXR7; SDYS; SGBS; OCI-5; SGBS1; GTR2-2 |
Gene ID : | 2719 |
mRNA Refseq : | NM_001164617.2 |
Protein Refseq : | NP_001158089.1 |
MIM : | 300037 |
UniProt ID : | P51654 |
Products Types
◆ Recombinant Protein | ||
Gpc3-272M | Recombinant Mouse Gpc3 Protein, His-tagged | +Inquiry |
Gpc3-273M | Recombinant Mouse Gpc3 Protein, Fc-tagged | +Inquiry |
GPC3-269C | Recombinant Cynomolgus monkey GPC3 Protein, Fc-tagged | +Inquiry |
GPC3-271H | Recombinant Human GPC3 Protein, His-tagged | +Inquiry |
GPC3-5147H | Recombinant Human GPC3 Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
GPC3-2538HCL | Recombinant Human GPC3 cell lysate | +Inquiry |
GPC3-001MCL | Recombinant Mouse GPC3 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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