Glypican-3 (GPC3) is a glycosylphospatidyl inositol-anchored membrane protein, which may also be found in a secreted form. Recently, GPC3 was identified to be useful tumor marker for the diagnosis of HCC, hepatoblastoma, melanoma, testicular germ cell tum
GPC3 involved in several pathways and played different roles in them. We selected most pathways GPC3 participated on our site, such as Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
GPC3 has several biochemical functions, for example, heparan sulfate proteoglycan binding, peptidyl-dipeptidase inhibitor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GPC3 itself. We selected most functions GPC3 had, and list some proteins which have the same functions with GPC3. You can find most of the proteins on our site.
GPC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPC3.
Zaghloul, RA; El-Shishtawy, MM; et al. Evaluation of antiglypican-3 therapy as a promising target for amelioration of hepatic tissue damage in hepatocellular carcinoma. EUROPEAN JOURNAL OF PHARMACOLOGY 746:353-362(2015).
Tretiakova, M; Zynger, DL; et al. Glypican 3 overexpression in primary and metastatic Wilms tumors. VIRCHOWS ARCHIV 466:67-76(2015).