GPC3 Protein

GPC3

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GPC3

Official Full Name glypican 3
Background Glypican-3 (GPC3) is a glycosylphospatidyl inositol-anchored membrane protein, which may also be found in a secreted form. Recently, GPC3 was identified to be useful tumor marker for the diagnosis of HCC, hepatoblastoma, melanoma, testicular germ cell tum
Synonyms GPC3; glypican 3; SDYS; glypican-3; DGSX; glypican proteoglycan 3; OCI 5; SGB; SGBS; SGBS1; secreted glypican-3; intestinal protein OCI-5; heparan sulphate proteoglycan; MXR7; OCI-5; GTR2-2
    • Species :
    • Chimpanzee
    • Cynomolgus
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • CHO cells
    • E.coli
    • HEK293
    • Human Cell
    • Insect Cell
    • Mammalian cells
    • Wheat Germ
    • Yeast
    • Tag :
    • C-6His-Avi
    • Fc
    • GST
    • hFc
    • His
    • His/Avi
    • His/Myc
    • His\Avi
    • Avi
    • T7
    • human
    • IgG1
    • mFc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GPC3-619H Active Recombinant Human GPC3, Fc-tagged, Biotinylated Human Cell Fc Inquiry
    Human GPC3-620H Active Recombinant Human GPC3, Fc-tagged Human Cell Fc Inquiry
    Mouse Gpc3-506M Active Recombinant Mouse Gpc3, His-tagged Insect Cell His Inquiry
    Mouse Gpc3-5627M Active Recombinant Mouse Gpc3, His-tagged Mammalian cells His Inquiry
    Human GPC3-051H Active Recombinant Human GPC3 protein, His/Avi-tagged, Biotinylated CHO cells His/Avi Inquiry
    Human GPC3-138H Active Recombinant Human GPC3 Protein(495S/A), hFc-tagged HEK293 hFc Inquiry
    Human GPC3-620HAF488 Active Recombinant Human GPC3 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
    Human GPC3-620HAF555 Active Recombinant Human GPC3 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
    Human GPC3-620HAF647 Active Recombinant Human GPC3 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
    Human GPC3-620HF Active Recombinant Human GPC3 Protein, Fc-tagged, FITC conjugated HEK293 Fc
    Human GPC3-338H Active Recombinant Human GPC3 Protein (Gln 25 - His 559), Fc-tagged, FITC-Labeled HEK293 Fc Inquiry
    Human GPC3-2246H Recombinant Human GPC3 protein (S359F), His-tagged, low endotoxin HEK293 His Inquiry
    Human GPC3-2551H Recombinant Human GPC3 protein, His-tagged HEK293 His
    Human GPC3-27455TH Recombinant Human GPC3 Wheat Germ N/A Inquiry
    Human GPC3-50H Recombinant Human GPC3 Yeast N/A Inquiry
    Human GPC3-5683H Recombinant Human GPC3 protein, His & GST-tagged E.coli His/GST Inquiry
    Mouse Gpc3-120M Recombinant Mouse Gpc3 protein, Fc-tagged HEK293 human/IgG1/Fc Inquiry
    Mouse Gpc3-5684M Recombinant Mouse Gpc3 protein, His & T7-tagged E.coli His/T7 Inquiry
    Rat GPC3-2633R Recombinant Rat Gpc3 protein, His-tagged E.coli His Inquiry
    Cynomolgus GPC3-50C Recombinant Cynomolgus GPC3 protein, Fc-tagged HEK293 human/IgG1/Fc Inquiry
    Human GPC3-2538HCL Recombinant Human GPC3 cell lysate Human Cell N/A Inquiry
    Mouse GPC3-001MCL Recombinant Mouse GPC3 cell lysate Insect Cell N/A Inquiry
    Rhesus Macaque GPC3-1120R Recombinant Rhesus Macaque GPC3(Gln25-His559) Protein, C-6*His-tagged HEK293 His Inquiry
    Mouse Gpc3-120MAF488 Recombinant Mouse Gpc3 Protein, hFc-tagged, Alexa Fluor 488 conjugated HEK293 hFc
    Mouse Gpc3-120MAF555 Recombinant Mouse Gpc3 Protein, hFc-tagged, Alexa Fluor 555 conjugated HEK293 hFc
    Mouse Gpc3-120MAF647 Recombinant Mouse Gpc3 Protein, hFc-tagged, Alexa Fluor 647 conjugated HEK293 hFc
    Mouse Gpc3-120MF Recombinant Mouse Gpc3 Protein, hFc-tagged, FITC conjugated HEK293 hFc
    Rat GPC3-1305R Recombinant Rat GPC3 protein, His-tagged HEK293 His Inquiry
    Human GPC3-1456H Recombinant Human GPC3 protein, His-Myc-tagged HEK293 His/Myc Inquiry
    Human GPC3-14H Recombinant Human GPC3 Protein, C-6His-Avi tagged, Biotinylated Human Cell C-6His-Avi Inquiry
    Human GPC3-186H Recombinant Human GPC3 Protein, His\Avi-tagged Human Cell His\Avi Inquiry
    Human GPC3-2246HAF488 Recombinant Human GPC3 Protein (S359F), His-tagged, low endotoxin, Alexa Fluor 488 conjugated HEK293 His
    Human GPC3-2246HAF555 Recombinant Human GPC3 Protein (S359F), His-tagged, low endotoxin, Alexa Fluor 555 conjugated HEK293 His
    Human GPC3-2246HAF647 Recombinant Human GPC3 Protein (S359F), His-tagged, low endotoxin, Alexa Fluor 647 conjugated HEK293 His
    Human GPC3-2246HF Recombinant Human GPC3 Protein (S359F), His-tagged, low endotoxin, FITC conjugated HEK293 His
    Human GPC3-336H Recombinant Human GPC3 Protein(495S/A), mFc-tagged HEK293 mFc Inquiry
    Chimpanzee GPC3-5020C Recombinant Chimpanzee GPC3 protein, His-tagged HEK293 His Inquiry
    Cynomolgus GPC3-50CAAF488 Recombinant Cynomolgus GPC3 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
    Cynomolgus GPC3-50CAAF555 Recombinant Cynomolgus GPC3 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
    Cynomolgus GPC3-50CAAF647 Recombinant Cynomolgus GPC3 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
    Cynomolgus GPC3-50CAF Recombinant Cynomolgus GPC3 Protein, Fc-tagged, FITC conjugated HEK293 Fc
    Cynomolgus GPC3-50CAF488 Recombinant Cynomolgus GPC3 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc Inquiry
    Cynomolgus GPC3-50CAF555 Recombinant Cynomolgus GPC3 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc Inquiry
    Cynomolgus GPC3-50CAF647 Recombinant Cynomolgus GPC3 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc Inquiry
    Cynomolgus GPC3-50CF Recombinant Cynomolgus GPC3 Protein, Fc-tagged, FITC conjugated HEK293 Fc Inquiry
    Cynomolgus GPC3-50CPAF488 Recombinant Monkey GPC3 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
    Cynomolgus GPC3-50CPAF555 Recombinant Monkey GPC3 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
    Cynomolgus GPC3-50CPAF647 Recombinant Monkey GPC3 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
    Cynomolgus GPC3-50CPF Recombinant Monkey GPC3 Protein, His-tagged, FITC conjugated HEK293 His
    Rat Gpc3-5418R Recombinant Rat Gpc3 protein, His-tagged Yeast His Inquiry
    Human GPC3-2246HA Recombinant Human GPC3 protein, His-tagged, APC labeled Human Cell His Inquiry
    Human GPC3-2246HP Recombinant Human GPC3 protein, His-tagged, R-PE labeled Human Cell His Inquiry
    Human GPC3-2247H Recombinant Human GPC3 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi Inquiry
    Human GPC3-2551HB Recombinant Human GPC3 protein, His-tagged, Biotinylated HEK293 His Inquiry
    Human GPC3-337H Recombinant Human GPC3 Protein (Gln 25 - His 559), Fc-tagged, low endotoxin HEK293 Fc Inquiry
    Human GPC3-5147H Recombinant Human GPC3 Protein, GST-tagged Wheat Germ GST Inquiry
    Human GPC3-551HG GMP Recombinant Human GPC3 protein, His-tagged HEK293 His Inquiry
    Human GPC3-620HA Recombinant Human GPC3 protein, Fc-tagged, APC labeled HEK293 Fc Inquiry
    Human GPC3-620HP Recombinant Human GPC3 protein, Fc-tagged, R-PE labeled HEK293 Fc Inquiry
    Human GPC3-621H Recombinant Human GPC3 Protein, Fc-tagged HEK293 Fc Inquiry
    Mouse Gpc3-1118M Recombinant Mouse Gpc3 protein, His-tagged HEK293 His Inquiry
    Mouse Gpc3-120MA Recombinant Mouse Gpc3 protein, Fc-tagged, APC labeled HEK293 Fc Inquiry
    Mouse Gpc3-120MP Recombinant Mouse Gpc3 protein, Fc-tagged, R-PE labeled HEK293 Fc Inquiry
    Cynomolgus GPC3-1117C Recombinant Cynomolgus GPC3 protein, His-tagged HEK293 His Inquiry
    Cynomolgus GPC3-50CA Recombinant Cynomolgus GPC3 protein, Fc-tagged, APC labeled HEK293 Fc Inquiry
    Cynomolgus GPC3-50CP Recombinant Cynomolgus GPC3 protein, Fc-tagged, R-PE labeled HEK293 Fc Inquiry

    GPC3 involved in several pathways and played different roles in them. We selected most pathways GPC3 participated on our site, such as Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Proteoglycans in cancer MAPK12; FN1; PIK3CD; RPS6KB1; NANOG; PIK3CG; ARHGEF1; WNT3A; KRAS; HRAS

    GPC3 has several biochemical functions, for example, heparan sulfate proteoglycan binding, peptidyl-dipeptidase inhibitor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GPC3 itself. We selected most functions GPC3 had, and list some proteins which have the same functions with GPC3. You can find most of the proteins on our site.

    Function Related Protein
    heparan sulfate proteoglycan binding SLIT2; Itgam&Itgb2; GPC5A; UBE4A; GPC6A; AZU1; GPC5; PLA2G2D; HPSE2; GPC6
    peptidyl-dipeptidase inhibitor activity GPC3
    protein binding PIGS; SNRPE; INSIG1; PDCD10; SEC23B; CYP1A1; ZNF581; RB1CC1; LATS1; INTS5

    GPC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPC3.

    APPL1

    Zaghloul, RA; El-Shishtawy, MM; et al. Evaluation of antiglypican-3 therapy as a promising target for amelioration of hepatic tissue damage in hepatocellular carcinoma. EUROPEAN JOURNAL OF PHARMACOLOGY 746:353-362(2015).
    Tretiakova, M; Zynger, DL; et al. Glypican 3 overexpression in primary and metastatic Wilms tumors. VIRCHOWS ARCHIV 466:67-76(2015).

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