Recombinant Human GRK4 Protein (Ala187-Phe449), His tagged

• Cat.No.: GRK4-2601H
• Product Overview: Recombinant human GRK4 (Ala187-Phe449) protein fused with His tag was expressed in E. coli.

Specification

• Description: Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: 30.65 kDa
• Protein Length: Ala187-Phe449
• Purity: >90 % as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: GRK4 G protein-coupled receptor kinase 4 [ Homo sapiens (human) ]
• Official Symbol: GRK4
• Synonyms: GRK4; G protein-coupled receptor kinase 4; G protein coupled receptor kinase 2 like (Drosophila), GPRK2L; GPRK4; ITI1; IT11; GRK4a; GPRK2L
• Gene ID: 2868
• mRNA Refseq: NM_001004056
• Protein Refseq: NP_001004056
• MIM: 137026
• UniProt ID: P32298