Recombinant Human HAVCR2 Protein, His-tagged
Cat.No. : | HAVCR2-149H |
Product Overview : | Recombinant Human HAVCR2 Protein with His tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | T cell Ig- and mucin-domain-containing molecules (TIMs) are a family of transmembrane proteins expressed by various immune cells. TIM-3 is an inhibitory molecule that is induced following T cell activation. TIM-3 is expressed by exhausted T cells in the settings of chronic infection and cancer, and tumor-infiltrating T cells that coexpress PD-1 and TIM-3 exhibit the most severe exhausted phenotype. Tumor-infiltrating dendritic cells (DCs) also express TIM-3. TIM-3 expression on DCs was found to suppress innate immunity by reducing the immunogenicity of nucleic acids released by dying tumor cells. Research studies show that heterodimerization of TIM-3 with CEACAM-1 is critical for the inhibitory function of TIM-3, and co-blockade of TIM-3 and CEACAM-1 enhanced anti-tumor responses in a mouse model of colorectal cancer. In addition, blockade of TIM-3 in mouse models of autoimmunity enhanced the severity of disease. Finally, binding of Galectin-9 to TIM-3 expressed by Th1 cells induces T cell death. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Molecular Mass : | ~24 kDa |
AA Sequence : | MSEVEYRAEVGQNAYLPCFYTPAAP GNLVPVCWGKGACPVFECGNVVLRT DERDVNYWTSRYWLNGDFRKGDVSL TIENVTLADSGIYCCRIQIPGIMND EKFNLKLVIKPAKVTPAPTRQRDFT AAFPRMLTTRGHGPAETQTLGSLPD INLTQISTLANELRDSRLANDLRDS GATIRIG |
Purity : | Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). |
Notes : | For research use only, not for use in diagnostic procedure. |
Storage : | Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. |
Storage Buffer : | PBS, 4M Urea, pH7.4 |
Gene Name : | HAVCR2 hepatitis A virus cellular receptor 2 [ Homo sapiens (human) ] |
Official Symbol : | HAVCR2 |
Synonyms : | HAVCR2; hepatitis A virus cellular receptor 2; FLJ14428; Tim 3; TIM3; TIMD3; kidney injury molecule-3; T-cell membrane protein 3; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; T-cell immunoglobulin and mucin domain-containing protein 3; KIM-3; Tim-3; TIMD-3; HAVcr-2; |
Gene ID : | 84868 |
mRNA Refseq : | NM_032782 |
Protein Refseq : | NP_116171 |
MIM : | 606652 |
UniProt ID : | Q8TDQ0 |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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