"HGF" Related Products

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Recombinant Human HGF Protein

Cat.No. : HGF-4728H
Product Overview : Human HGF (heterodimer) (P14210, alpha chain 463 amino acids, beta chain 234 amino acids) recombinant protein expressed in Hi-5 cells.
Description : Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq
Source : Insect Cell
Species : Human
Form : Lyophilized
Bio-activity : The ED50 determined by the scattering activity in the MDCK cell assay is typically at 0.5-1.0 ng/mL.
Molecular Mass : 78 kDa
Endotoxin : < 0.1 ng/μg
Purity : >= 98% by SDS-PAGE and HPLC
Applications : Functional Study
SDS-PAGE
Storage : Store at -2 centigrade on dry atmosphere. After reconstitution with sterilized water, store at -2 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : Lyophilized from 50 mM acetic acid
Gene Name : HGF hepatocyte growth factor (hepapoietin A; scatter factor) [ Homo sapiens ]
Official Symbol : HGF
Synonyms : HGF; hepatocyte growth factor (hepapoietin A; scatter factor); deafness, autosomal recessive 39 , DFNB39; hepatocyte growth factor; F TCF; fibroblast derived tumor cytotoxic factor; hepatopoietin A; HGFB; HPTA; lung fibroblast derived mitogen; scatter factor; SF; hepatopoeitin-A; hepatopoietin-A; lung fibroblast-derived mitogen; fibroblast-derived tumor cytotoxic factor; F-TCF; DFNB39;
Gene ID : 3082
mRNA Refseq : NM_000601
Protein Refseq : NP_000592
MIM : 142409
UniProt ID : P14210

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