HGF

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HGF

Official Full Name hepatocyte growth factor (hepapoietin A; scatter factor)
Background Hepatocyte growth factor/scatter factor (HGF/SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on haemopoietic progenitor cells. It has been shown to have a major role in embryonic organ development, in adult organ regeneration and in wound healing.
Synonyms SF; HGFB; HPTA; F-TCF; DFNB39;Fibroblast derived tumor cytotoxic factor; Hepatocyte growth factor; Hepatocyte growth factor beta chain; Hepatocyte growth factor precursor; Hepatopoeitin-A; Hepatopoietin A; Hgf; Lung fibroblast derived mitogen; OTTHUMP00000161349; OTTHUMP00000206710; OTTHUMP00000206711; OTTHUMP00000206712; OTTHUMP00000206713; OTTHUMP00000206730; Scatter factor; Rilotumumab; 872514-65-3; Flanvotumab; 1188277-05-5
    • Species :
    • Canine
    • Chicken
    • Cynomolgus Monkey
    • Dog
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293T
    • Hi-5 Inscet Cell
    • Human
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Pig Liver
    • Sf21 Insect Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • Fc
    • His
    • GST
    • T7
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HGF-01H Recombinant Human HGF Protein HEK293
    Human HGF-001HCL Recombinant Human HGF cell lysate CHO N/A
    Human HGF-123H Recombinant Human Hepatocyte Growth Factor (Hepapoietin A; Scatter factor) CHO N/A
    Human HGF-13H Recombinant Human HGF Propeptide Protein Insect Cell N/A
    Human HGF-143HG GMP Recombinant Human HGF Protein Mammalian cells N/A
    Human HGF-157H Human Hepatocyte Growth Factor(precursor, rDNA derived) Reference standard Sf21 Insect Cell N/A
    Human HGF-158H Human Hepatocyte Growth Factor(rDNA derived) Reference standard CHO N/A
    Human HGF-195H Recombinant Human HGF protein HEK293 N/A
    Human HGF-210H Recombinant Human HGF protein, Fc-tagged HEK293 Fc
    Human HGF-225H Recombinant Human HGF E.coli N/A
    Human HGF-226H Recombinant Human HGF, 495-728aa, His-tagged E.coli His
    Human HGF-254H Recombinant Human HGF Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human HGF-27731TH Recombinant Human HGF, His-tagged E.coli His
    Human HGF-290H Recombinant Human HGF Sf9 Insect Cell N/A
    Human HGF-29231TH Native Human HGF N/A
    Human HGF-341H Recombinant Human HGF Mammalian cells N/A
    Human HGF-364H Recombinant Human HGF, His tagged Human Cell His
    Human HGF-4726H Recombinant Human HGF Protein E.coli N/A
    Human HGF-4728H Recombinant Human HGF Protein Insect Cell N/A
    Human HGF-4729H Recombinant Human HGF Protein, GST-tagged Wheat Germ GST
    Human HGF-501H Recombinant Human HGF Hi-5 Inscet Cell N/A
    Human HGF-5037H Recombinant Human HGF Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human HGF-543H Recombinant Human Hepatocyte Growth Factor Insect Cell Fc
    Human HGF-592H Recombinant Human Hepatocyte Growth Factor (Hepapoietin A; Scatter Factor) HEK293 N/A
    Human HGF-593H Recombinant Human HGF, His-tagged HEK293 His
    Human HGF-627H Recombinant Human Hepatocyte Growth Factor Human N/A
    Human HGF-6H Recombinant Human HGF Hi-5 Inscet Cell N/A
    Human HGF-792H Recombinant Human HGF protein, His & T7-tagged E.coli His/T7
    Human HGF-793H Recombinant Human HGF protein, His & GST-tagged E.coli His/GST
    Human HGF-8535H Recombinant Human HGF CHO N/A
    Human HGF-872H Recombinant Human HGF, None tagged CHO N/A
    Mouse Hgf-072M Recombinant Mouse Hgf Protein Insect Cell
    Mouse Hgf-073M Recombinant Mouse Hgf Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse HGF-1210MCL Recombinant Mouse HGF cell lysate Human Cell N/A
    Mouse Hgf-257M Recombinant Mouse Hgf Protein Insect Cell N/A
    Mouse Hgf-4731M Recombinant Mouse Hgf Protein Insect Cell N/A
    Mouse Hgf-599M Recombinant Mouse Hgf Insect Cell N/A
    Mouse Hgf-728M Recombinant Mouse Hepatocyte Growth Factor, His-tagged Mammalian cells His
    Mouse Hgf-734M Recombinant Mouse Hepatocyte Growth Factor Mammalian cells N/A
    Mouse Hgf-794M Recombinant Mouse Hgf protein, His-tagged E.coli His
    Mouse Hgf-8664M Recombinant Mouse Hgf, His tagged Human Cell His
    Mouse Hgf-8665M Recombinant Mouse Hgf, None tagged Human Cell Fc/His
    Rat HGF-1233RCL Recombinant Rat HGF cell lysate Human Cell N/A
    Rat Hgf-1237R Recombinant Rat Hgf Protein, GST-tagged E.coli GST
    Rat HGF-2836R Recombinant Rat HGF Protein Mammalian Cell His
    Rat Hgf-795R Recombinant Rat Hgf protein, His-tagged E.coli His
    Rat Hgf-8806R Recombinant Rat Hgf, None tagged Human Cell N/A
    Cynomolgus Monkey HGF-1077CCL Recombinant Cynomolgus HGF cell lysate Human Cell N/A
    Cynomolgus Monkey HGF-152C Recombinant Cynomolgus HGF, None tagged Human Cell Fc/His
    Canine HGF-1045C Recombinant Canine HGF Protein HEK293 N/A
    Dog HGF-791D Recombinant Dog HGF protein, His & T7-tagged E.coli His/T7
    Chicken HGF-2239C Recombinant Chicken HGF Mammalian Cell His
    Rabbit HGF-796R Recombinant Rabbit HGF protein, His & T7-tagged E.coli His/T7
    Pig HGF-38P Native Porcine HGF Pig Liver N/A

    HGF involved in several pathways and played different roles in them. We selected most pathways HGF participated on our site, such as Ras signaling pathway, Rap signaling pathway, Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with HGF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ras signaling pathway FGF11; EFNA4; ANGPT1; PIK3CG; FASLG; RAC2; CALML3; GNG5; PLA2G1B; PIK3R1
    Rap signaling pathway HRAS; LPAR2; F2RL3; PIK3R2; FLT4; NGFR; ITGA2B; FGF19; MAP2K3; FGF2
    Cytokine-cytokine receptor interaction IL15RA; IL6; IFNA12; LTB; CCL4L2; IL20RB; KITB; IFNA13; IL5RA; IL20RA
    PIK-Akt signaling pathway YWHAH; IFNA16; GYS1; EIF4E1B; PPP2R5B; FGF22; PHLPP1; MDM2; COL6A5; ITGB7
    Focal adhesion KDRL; ITGB1B.2; CAPN2L; ACTB2; ITGA7; THBS3; LAMA1; COL27A1; AKT3A; TLN1
    Malaria CCL2; ITGAL; TGFB2; SELP; TGFB1; HGF; DARC; TNF; KLRK1; CSF3
    Pathways in cancer CBLC; FGF11; PDGFRB; FH1; VEGFA; LAMA5; BRCA2; ETS1; BIRC5; NFKB1
    Proteoglycans in cancer TNF; IGF1R; PIK3R3; PIK3CG; SOS1; WNT3; WNT2; PLCG2; THBS1; PDCD4
    Renal cell carcinoma KRAS; NRAS; EPAS1; PIK3CD; RAC1; TCEB2; PAK1; HGF; PIK3R5; PIK3CB
    Melanoma FGF5; BRAF; MAP2K2; PIK3R5; FGF1; CDH1; BAD; IGF1R; PIK3R2; HGF

    HGF has several biochemical functions, for example, chemoattractant activity, growth factor activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HGF itself. We selected most functions HGF had, and list some proteins which have the same functions with HGF. You can find most of the proteins on our site.

    Function Related Protein
    chemoattractant activity FGF8; MIF; CXCL12; NTF3; FGF10; FIGF; CXCL12B; CXCL12A; HMGB2; VHL
    growth factor activity INHBB; MDKB; OSM; GPI1; IGF2A; VHL; PTN; MSTN; NUDT6; PDGFAB
    identical protein binding PKD2; HSP90AA1; PRNP; PCM1; HOOK1; APLP2; TRIP10; KHDC1A; BAIAP2; ATL1
    protein binding RSL24D1; PIN4; CTSH; NR3C1; OPRD1; ADRBK1; SNX1; RUNX1T1; PRKAA1; TBC1D1
    protein heterodimerization activity TAP1; BCL2A; ALX4; MAFA; HIST1H2BE; ADIPOR1; SPTAN1; ADORA2A; USF1; H2AFB2
    serine-type endopeptidase activity F11; PRSS3; PRSS58; KLK6; KLK11; GZMB; CFI; CFD; PCSK4; KLK14
    NOT serine-type endopeptidase activity RHBDF1; RHBDF2; HGF

    HGF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HGF here. Most of them are supplied by our site. Hope this information will be useful for your research of HGF.

    MET; MEOX2; Met; ADAMTSL4; SRPX2; Hgf; FN1; CD44

    Pena-Silva, RA; Chalouhi, N; et al. Novel Role for Endogenous Hepatocyte Growth Factor in the Pathogenesis of Intracranial Aneurysms. HYPERTENSION 65:587-593(2015).
    Wang, YQ; Fukuda, T; et al. Loss of alpha 1,6-fucosyltransferase suppressed liver regeneration: implication of core fucose in the regulation of growth factor receptor-mediated cellular signaling. SCIENTIFIC REPORTS 5:-(2015).

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