Recombinant Human HHLA2 Protein, Fc-tagged


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Recombinant Human HHLA2 Protein, Fc-tagged

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Cat.No. : HHLA2-421H
Product Overview : Recombinant Human HHLA2 (NP_009003.1) (Met1-Asn344) was expressed with the Fc region of human IgG1 at the C-terminus.
Description : B7H7 gene encodes a protein ligand found on the surface of mon centigradeytes. The encoded protein is thought to regulate cell-mediated immunity by binding to a receptor on T lymph centigradeytes and inhibiting the proliferation of these cells. Alternate splicing results in multiple transcript variants.
HERV–H LTR-ass centigradeiating 2 (HHLA2, also called B7H7/B7-H5/B7y)has been recently discovered as the newest member of the B7 family and has 23–33% similarity in amino acid sequence with the other B7 molecules. This ligand is the only B7 family member that is found in humans but not in mice. It is constitutively expressed on the surface of human mon centigradeytes and is induced on B cells. HHLA2 binds to its putative receptor(s) on a variety of immune cells including CD4 and CD8 T cells and antigen-presenting cells. Similarly to B7-H3, both a T cell coinhibitory role as well as a costimulatory role has been reported for this ligand.
Source : HEK293
Species : Human
Tag : Fc
Predicted N Terminal : Ile 23
Form : Lyophilized from sterile PBS, pH 7.4. Normally 5 %- 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Bio-activity : Measured by its binding ability in a functional ELISA. Immobilized human TMIGD2 at 10μg/mL (100μL/well) can bind human HHLA2-Fc, the EC50 of human HHLA2-Fc is 0.3-3μg/mL.
Molecular Mass : The recombinant human HHLA2 consists 560 amino acids and predicts a molecular mass of 63.7 kDa
Protein length : Met1-Asn344
Endotoxin : < 1.0 EU per μg protein as determined by the LAL method.
Purity : > 90 % as determined by SDS-PAGE.
Storage : Samples are stable for up to twelve months from date of receipt at-70 centigrade. Store it under sterile conditions at-20 centigrade to-80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.
Gene Name : HHLA2 HERV-H LTR-associating 2 [ Homo sapiens ]
Official Symbol : HHLA2
Synonyms : HHLA2; HERV-H LTR-associating 2; HERV-H LTR-associating protein 2; human endogenous retrovirus-H long terminal repeat-associating protein 2;
Gene ID : 11148
mRNA Refseq : NM_007072
Protein Refseq : NP_009003
MIM : 604371
UniProt ID : Q9UM44
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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