Recombinant Human HSD3B7 Protein, GST-tagged

• Cat.No.: HSD3B7-5081H
• Product Overview: Human HSD3B7 full-length ORF ( NP_079469.2, 1 a.a. - 369 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes an enzyme which is involved in the initial stages of the synthesis of bile acids from cholesterol and a member of the short-chain dehydrogenase/reductase superfamily. The encoded protein is a membrane-associated endoplasmic reticulum protein which is active against 7-alpha hydrosylated sterol substrates. Mutations in this gene are associated with a congenital bile acid synthesis defect which leads to neonatal cholestasis, a form of progressive liver disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 67.4 kDa
• AA Sequence: MADSAQAQKLVYLVTGGCGFLGEHV VRMLLQREPRLGELRVFDQHLGPWL EELKTGPVRVTAIQGDVTQAHEVAA AVAGAHVVIHTAGLVDVFGRASPKT IHEVNVQGTRNVIEACVQTGTRFLV YTSSMEVVGPNTKGHPFYRGNEDTP YEAVHRHPYPCSKALAEWLVLEANG RKVRGGLPLVTCALRPTGIYGEGHQ IMRDFYRQGLRLGGWLFRAIPASVE HGRVYVGNVAWMHVLAARELEQRAT LMGGQVYFCYDGSPYRSYEDFNMEF LGPCGLRLVGARPLLPYWLLVFLAA LNALLQWLLRPLVLYAPLLNPYTLA VANTTFTVSTDKAQRHFGYEPLFSW EDSRTRTILWVQAATGSAQ
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 [ Homo sapiens ]
• Official Symbol: HSD3B7
• Synonyms: HSD3B7; hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7; 3 beta-hydroxysteroid dehydrogenase type 7; C(27) 3BETA HSD; SDR11E3; short chain dehydrogenase/reductase family 11E; member 3; 3-beta-HSD VII; C(27)-3BETA-HSD; c(27) 3-beta-HSD; 3 beta-hydroxysteroid dehydrogenase type VII; 3 beta-hydroxy-delta 5-C27-steroid oxidoreductase; 3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase; cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase; short chain dehydrogenase/reductase family 11E, member 3; CBAS1; PFIC4
• Gene ID: 80270
• mRNA Refseq: NM_025193
• Protein Refseq: NP_079469
• MIM: 607764
• UniProt ID: Q9H2F3