Recombinant Human HSPA5 Protein, GST-tagged

• Cat.No.: HSPA5-5107H
• Product Overview: Human HSPA5 full-length ORF ( AAH20235.1, 19 a.a. - 654 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: When Chinese hamster K12 cells are starved of glucose, the synthesis of several proteins, called glucose-regulated proteins (GRPs), is markedly increased. Hendershot et al. (1994) [PubMed 8020977] pointed out that one of these, GRP78 (HSPA5), also referred to as immunoglobulin heavy chain-binding protein (BiP), is a member of the heat-shock protein-70 (HSP70) family and is involved in the folding and assembly of proteins in the endoplasmic reticulum (ER). Because so many ER proteins interact transiently with GRP78, it may play a key role in monitoring protein transport through the cell.[supplied by OMIM
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 95.7 kDa
• AA Sequence: EEEDKKEDVGTVVGIDLGTTYSCVG VFKNGRVEIIANDQGNRITPSYVAF TPEGERLIGDAAKNQLTSNPENTVF DAKRLIGRTWNDPSVQQDIKFLPFK VVEKKTKPYIQVDIGGGQTKTFAPE EISAMVLTKMKETAEAYLGKKVTHA VVTVPAYFNDAQRQATKDAGTIAGL NVMRIINEPTAAAIAYGLDKREGEK NILVFDLGGGTFDVSLLTIDNGVFE VVATNGDTHLGGEDFDQRVMEHFIK LYKKKTGKDVRKDNRAVQKLRREVE KAKRALSSQHQARIEIESFYEGEDF SETLTRAKFEELNMDLFRSTMKPVQ KVLEDSDLKKSDIDEIVLVGGSTRI PKIQQLVKEFFNGKEPSRGINPDEA VAYGAAVQAGVLSGDQDTGDLVLLD VCPLTLGIETVGGVMTKLIPRNTVV PTKKSQIFSTASDNQPTVTIKVYEG ERPLTKDNHLLGTFDLTGIPPAPRG VPQIEVTFEIDVNGILRVTAEDKGT GNKNKITITNDQNRLTPEEIERMVN DAEKFAEEDKKLKERIDTRNELESY AYSLKNQIGDKEKLGGKLSSEDKET MEKAVEEKIEWLESHQDADIEDFKA KKKELEEIVQPIISKLYGSAGPPPT GEEDTAEKDEL
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [ Homo sapiens ]
• Official Symbol: HSPA5
• Synonyms: HSPA5; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); GRP78, heat shock 70kD protein 5 (glucose regulated protein, 78kD); 78 kDa glucose-regulated protein; BiP; immunoglobulin heavy chain-binding protein; endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; BIP; MIF2; GRP78; FLJ26106
• Gene ID: 3309
• mRNA Refseq: NM_005347
• Protein Refseq: NP_005338
• MIM: 138120
• UniProt ID: P11021

Reviews

07/02/2022

This level of support ensures that researchers have a seamless experience, enabling them to focus on their research goals without worrying about logistical or technical concerns.

01/18/2020

Its versatility in various biological applications, along with its compatibility with different techniques, strongly recommend it as a preferred reagent for researchers in the field.

07/07/2019

researchers highly appreciate HSPA5 protein for its excellent performance in ELISA assays and protein electron microscopy structure analysis.

Q&As

Are there drugs targeting HSPA5 currently in development?

Some studies explore small molecules and compounds that target HSPA5 as potential therapeutic agents, but clinical applications are still under investigation.

In what other medical conditions is HSPA5 relevant?

HSPA5 is involved in various conditions, including cardiovascular diseases, diabetes, and neurodegenerative disorders.

Are there diagnostic applications of HSPA5 in cancer?

Elevated levels of HSPA5 in certain cancers may serve as a diagnostic marker, providing information about the cellular stress response and potential malignancy.

Is there a relationship between HSPA5 and autoimmune disorders?

HSPA5's involvement in the immune response suggests potential links to autoimmune disorders, but specific mechanisms are still being studied.

How does HSPA5 influence the immune response?

HSPA5 is involved in antigen presentation, linking its role in protein folding to the modulation of immune responses.