Recombinant Human HSPA5 Protein, His-tagged

PRODUCTS

Home / Products / Recombinant Proteins / Recombinant Human HSPA5 Protein, His-tagged

Recombinant Human HSPA5 Protein, His-tagged

HSPA5 Related Products

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.

Cat.No. : HSPA5-8943H
Product Overview : Recombinant human HSPA5 protein (19-654aa), fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Description : The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins in the ER and is a master regulator of ER homeostasis. During cellular stress, as during viral infection or tumorogenesis, this protein interacts with the transmembrane stress sensor proteins PERK (protein kinase R-like endoplasmic reticulum kinase), IRE1 (inositol-requiring kinase 1), and ATF6 (activating transcription factor 6) where it acts as a repressor of the unfolded protein response (UPR) and also plays a role in cellular apoptosis and senescence. Elevated expression and atypical translocation of this protein to the cell surface has been reported in viral infections and some types of cancer cells. At the cell surface this protein may facilitate viral attachment and entry to host cells. This gene is a therapeutic target for the treatment of coronavirus diseases and chemoresistant cancers.
Source : E. coli
Species : Human
Tag : His
Form : Liquid
Molecular Mass : 72.9 kDa (659aa)
Protein length : 19-654
AA Sequence : <MGSSHHHHH HSSGLVPRGS HMGS>EEEDK KEDVGTVVGI DLGTTYSCVG VFKNGRVEII ANDQGNRITP SYVAFTPEGE RLIGDAAKNQ LTSNPENTVF DAKRLIGRTW NDPSVQQDIK FLPFKVVEKK TKPYIQVDIG GGQTKTFAPE EISAMVLTKM KETAEAYLGK KVTHAVVTVP AYFNDAQRQA TKDAGTIAGL NVMRIINEPT AAAIAYGLDK REGEKNILVF DLGGGTFDVS LLTIDNGVFE VVATNGDTHL GGEDFDQRVM EHFIKLYKKK TGKDVRKDNR AVQKLRREVE KAKRALSSQH QARIEIESFY EGEDFSETLT RAKFEELNMD LFRSTMKPVQ KVLEDSDLKK SDIDEIVLVG GSTRIPKIQQ LVKEFFNGKE PSRGINPDEA VAYGAAVQAG VLSGDQDTGD LVLLDVCPLT LGIETVGGVM TKLIPRNTVV PTKKSQIFST ASDNQPTVTI KVYEGERPLT KDNHLLGTFD LTGIPPAPRG VPQIEVTFEI DVNGILRVTA EDKGTGNKNK ITITNDQNRL TPEEIERMVN DAEKFAEEDK KLKERIDTRN ELESYAYSLK NQIGDKEKLG GKLSSEDKET MEKAVEEKIE WLESHQDADI EDFKAKKKEL EEIVQPIISK LYGSAGPPPT GEEDTAEKDE L
Purity : > 90% by SDS-PAGE
Applications : SDS-PAGE
Storage : Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 1 mg/mL (determined by Bradford assay)
Storage Buffer : 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol, 1mM DTT
Figure :

Gene Name : HSPA5 heat shock protein family A (Hsp70) member 5 [ Homo sapiens (human) ]
Official Symbol : HSPA5
Synonyms : HSPA5; heat shock protein family A (Hsp70) member 5; BIP; GRP78; HEL-S-89n; endoplasmic reticulum chaperone BiP; 78 kDa glucose-regulated protein; HSP70 family protein 5; binding-immunoglobulin protein; endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; epididymis secretory sperm binding protein Li 89n; glucose-regulated protein, 78kDa; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); heat shock protein 70 family protein 5; heat shock protein family A member 5; immunoglobulin heavy chain-binding protein; EC 3.6.4.10
Gene ID : 3309
mRNA Refseq : NM_005347
Protein Refseq : NP_005338
MIM : 138120
UniProt ID : P11021
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Online Inquiry


  • Note: There will be extra charge for optional service!

Optional Service: Optional requirements on this protein

Other Requirements:

Apply For A Coupon

$50 OFF Your First Purchase

Apply For a Coupon

Enter your email here to subscribe.

creative biomart inc.

Easy access to products and services you need from our library via powerful searching tools.

Follow Us

Copyright © 2021 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy