Recombinant Human HSPA5 Protein, His-tagged
Cat.No. : | HSPA5-8943H |
Product Overview : | Recombinant human HSPA5 protein (19-654aa), fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins in the ER and is a master regulator of ER homeostasis. During cellular stress, as during viral infection or tumorogenesis, this protein interacts with the transmembrane stress sensor proteins PERK (protein kinase R-like endoplasmic reticulum kinase), IRE1 (inositol-requiring kinase 1), and ATF6 (activating transcription factor 6) where it acts as a repressor of the unfolded protein response (UPR) and also plays a role in cellular apoptosis and senescence. Elevated expression and atypical translocation of this protein to the cell surface has been reported in viral infections and some types of cancer cells. At the cell surface this protein may facilitate viral attachment and entry to host cells. This gene is a therapeutic target for the treatment of coronavirus diseases and chemoresistant cancers. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Liquid |
Molecular Mass : | 72.9 kDa (659aa) |
Protein length : | 19-654 |
AA Sequence : | |
Purity : | > 90% by SDS-PAGE |
Applications : | SDS-PAGE |
Storage : | Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles. |
Concentration : | 1 mg/mL (determined by Bradford assay) |
Storage Buffer : | 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol, 1mM DTT |
Gene Name : | HSPA5 heat shock protein family A (Hsp70) member 5 [ Homo sapiens (human) ] |
Official Symbol : | HSPA5 |
Synonyms : | HSPA5; heat shock protein family A (Hsp70) member 5; BIP; GRP78; HEL-S-89n; endoplasmic reticulum chaperone BiP; 78 kDa glucose-regulated protein; HSP70 family protein 5; binding-immunoglobulin protein; endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; epididymis secretory sperm binding protein Li 89n; glucose-regulated protein, 78kDa; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); heat shock protein 70 family protein 5; heat shock protein family A member 5; immunoglobulin heavy chain-binding protein; EC 3.6.4.10 |
Gene ID : | 3309 |
mRNA Refseq : | NM_005347 |
Protein Refseq : | NP_005338 |
MIM : | 138120 |
UniProt ID : | P11021 |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionSome studies explore small molecules and compounds that target HSPA5 as potential therapeutic agents, but clinical applications are still under investigation.
HSPA5 is involved in various conditions, including cardiovascular diseases, diabetes, and neurodegenerative disorders.
Elevated levels of HSPA5 in certain cancers may serve as a diagnostic marker, providing information about the cellular stress response and potential malignancy.
HSPA5's involvement in the immune response suggests potential links to autoimmune disorders, but specific mechanisms are still being studied.
HSPA5 is involved in antigen presentation, linking its role in protein folding to the modulation of immune responses.
Customer Reviews (3)
Write a reviewThis level of support ensures that researchers have a seamless experience, enabling them to focus on their research goals without worrying about logistical or technical concerns.
Its versatility in various biological applications, along with its compatibility with different techniques, strongly recommend it as a preferred reagent for researchers in the field.
researchers highly appreciate HSPA5 protein for its excellent performance in ELISA assays and protein electron microscopy structure analysis.
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