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Recombinant Human HSPA5 Protein, His-tagged

Cat.No. : HSPA5-8943H
Product Overview : Recombinant human HSPA5 protein (19-654aa), fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
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Description : The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins in the ER and is a master regulator of ER homeostasis. During cellular stress, as during viral infection or tumorogenesis, this protein interacts with the transmembrane stress sensor proteins PERK (protein kinase R-like endoplasmic reticulum kinase), IRE1 (inositol-requiring kinase 1), and ATF6 (activating transcription factor 6) where it acts as a repressor of the unfolded protein response (UPR) and also plays a role in cellular apoptosis and senescence. Elevated expression and atypical translocation of this protein to the cell surface has been reported in viral infections and some types of cancer cells. At the cell surface this protein may facilitate viral attachment and entry to host cells. This gene is a therapeutic target for the treatment of coronavirus diseases and chemoresistant cancers.
Source : E. coli
Species : Human
Tag : His
Form : Liquid
Molecular Mass : 72.9 kDa (659aa)
Protein length : 19-654
AA Sequence : EEEDKKEDVGTVVGIDLGTTYSCVG VFKNGRVEIIANDQGNRITPSYVAF TPEGERLIGDAAKNQLTSNPENTVF DAKRLIGRTWNDPSVQQDIKFLPFK VVEKKTKPYIQVDIGGGQTKTFAPE EISAMVLTKMKETAEAYLGKKVTHA VVTVPAYFNDAQRQATKDAGTIAGL NVMRIINEPTAAAIAYGLDKREGEK NILVFDLGGGTFDVSLLTIDNGVFE VVATNGDTHLGGEDFDQRVMEHFIK LYKKKTGKDVRKDNRAVQKLRREVE KAKRALSSQHQARIEIESFYEGEDF SETLTRAKFEELNMDLFRSTMKPVQ KVLEDSDLKKSDIDEIVLVGGSTRI PKIQQLVKEFFNGKEPSRGINPDEA VAYGAAVQAGVLSGDQDTGDLVLLD VCPLTLGIETVGGVMTKLIPRNTVV PTKKSQIFSTASDNQPTVTIKVYEG ERPLTKDNHLLGTFDLTGIPPAPRG VPQIEVTFEIDVNGILRVTAEDKGT GNKNKITITNDQNRLTPEEIERMVN DAEKFAEEDKKLKERIDTRNELESY AYSLKNQIGDKEKLGGKLSSEDKET MEKAVEEKIEWLESHQDADIEDFKA KKKELEEIVQPIISKLYGSAGPPPT GEEDTAEKDEL
Purity : > 90% by SDS-PAGE
Applications : SDS-PAGE
Storage : Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 1 mg/mL (determined by Bradford assay)
Storage Buffer : 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol, 1mM DTT
Gene Name : HSPA5 heat shock protein family A (Hsp70) member 5 [ Homo sapiens (human) ]
Official Symbol : HSPA5
Synonyms : HSPA5; heat shock protein family A (Hsp70) member 5; BIP; GRP78; HEL-S-89n; endoplasmic reticulum chaperone BiP; 78 kDa glucose-regulated protein; HSP70 family protein 5; binding-immunoglobulin protein; endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; epididymis secretory sperm binding protein Li 89n; glucose-regulated protein, 78kDa; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); heat shock protein 70 family protein 5; heat shock protein family A member 5; immunoglobulin heavy chain-binding protein; EC 3.6.4.10
Gene ID : 3309
mRNA Refseq : NM_005347
Protein Refseq : NP_005338
MIM : 138120
UniProt ID : P11021

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there drugs targeting HSPA5 currently in development? 03/16/2021

Some studies explore small molecules and compounds that target HSPA5 as potential therapeutic agents, but clinical applications are still under investigation.

In what other medical conditions is HSPA5 relevant? 01/27/2021

HSPA5 is involved in various conditions, including cardiovascular diseases, diabetes, and neurodegenerative disorders.

Are there diagnostic applications of HSPA5 in cancer? 03/16/2018

Elevated levels of HSPA5 in certain cancers may serve as a diagnostic marker, providing information about the cellular stress response and potential malignancy.

Is there a relationship between HSPA5 and autoimmune disorders? 11/19/2017

HSPA5's involvement in the immune response suggests potential links to autoimmune disorders, but specific mechanisms are still being studied.

How does HSPA5 influence the immune response? 03/25/2016

HSPA5 is involved in antigen presentation, linking its role in protein folding to the modulation of immune responses.

Customer Reviews (3)

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Reviews
07/02/2022

    This level of support ensures that researchers have a seamless experience, enabling them to focus on their research goals without worrying about logistical or technical concerns.

    01/18/2020

      Its versatility in various biological applications, along with its compatibility with different techniques, strongly recommend it as a preferred reagent for researchers in the field.

      07/07/2019

        researchers highly appreciate HSPA5 protein for its excellent performance in ELISA assays and protein electron microscopy structure analysis.

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