Species : |
Human |
Source : |
E.coli |
Tag : |
His |
Protein Length : |
196 amino acids |
Description : |
The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. |
Conjugation : |
HIS |
Molecular Weight : |
23.700kDa inclusive of tags |
Tissue specificity : |
Predominantly expressed in skeletal muscle and heart. |
Form : |
Liquid |
Purity : |
>95% by SDS-PAGE |
Storage buffer : |
pH: 8.00Constituents:10% Glycerol, 0.58% Sodium chloride, 0.32% Tris HCl |
Storage : |
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : |
MGSSHHHHHH SSGLVPRGSH MADGQMPFSC HYPSRLRRDP FRDSPLSSRL LDDGFGMDPF PDDLTASWPD WALPRLSSAW PGTLRSGMVP RGPTATARFG VPAEGRTPPP FPGEPWKVCV NVHSFKPEEL MVKTKDGYVE VSGKHEEKQQ EGGIVSKNFT KKIQLPAEVD PVTVFASLSP EGLLIIEAPQ VPPYSTFGES SFNNELPQDS QEVTCT |
Sequence Similarities : |
Belongs to the small heat shock protein (HSP20) family. |