HSPB8

  • Official Full Name

    heat shock 22kDa protein 8

  • Overview

    The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.
  • Synonyms

    HSPB8; heat shock 22kDa protein 8; H11; HMN2; CMT2L; DHMN2; E2IG1; HMN2A; HSP22; heat shock protein beta-8; OTTHUMP00000239768; protein kinase H11; alpha-crystallin C chain; E2-induced gene 1 protein; heat shock 27kDa protein 8; small stress protein-like protein HSP22;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|MBP
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HSPB8-1254H Recombinant Human Heat Shock 22kDa Protein 8 E.coli N/A
Human HSPB8-29389TH Recombinant Human HSPB8 E.coli N/A
Human HSPB8-5120H Recombinant Human HSPB8 Protein, GST-tagged Wheat Germ GST
Human HSPB8-27526TH Recombinant Human HSPB8, His-tagged E.coli His 196 amino acids
Human HSPB8-2025H Recombinant Human Heat Shock 22kDa Protein 8, His-tagged E.coli His
Human HSPB8-165H Recombinant Human HSPB8 protein, His/MBP-tagged E.coli His/MBP 1-145+170-196 aa
Human HSPB8-5345HCL Recombinant Human HSPB8 293 Cell Lysate HEK293 N/A
Human HSPB8-3969HF Recombinant Full Length Human HSPB8 Protein, GST-tagged In Vitro Cell Free System GST 196 amino acids
Human HSPB8-6700H Recombinant Human HSPB8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HSPB8-2016HFL Recombinant Full Length Human HSPB8 Protein, C-Flag-tagged Mammalian cells Flag
Human HSPB8-1123H Recombinant Human HSPB8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HSPB8-045H Recombinant Human HSPB8 Protein E.coli 196
Human HSPB8-1123H-B Recombinant Human HSPB8 Protein Pre-coupled Magnetic Beads HEK293
Human HSPB8-3504H Recombinant Human HSPB8 Protein (Met1-Thr196), C-His tagged E.coli C-His Met1-Thr196
Mouse HSPB8-7919M Recombinant Mouse HSPB8 Protein Mammalian Cell His
Mouse HSPB8-4366M Recombinant Mouse HSPB8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Hspb8-3457M Recombinant Mouse Hspb8 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse HSPB8-4366M-B Recombinant Mouse HSPB8 Protein Pre-coupled Magnetic Beads HEK293
Rat HSPB8-2954R Recombinant Rat HSPB8 Protein Mammalian Cell His
Rat HSPB8-2609R-B Recombinant Rat HSPB8 Protein Pre-coupled Magnetic Beads HEK293
Rat HSPB8-2609R Recombinant Rat HSPB8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HSPB8-2170R Recombinant Rhesus monkey HSPB8 Protein, His-tagged Mammalian Cell His
Rhesus Macaque HSPB8-1991R-B Recombinant Rhesus Macaque HSPB8 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque HSPB8-1991R Recombinant Rhesus Macaque HSPB8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish HSPB8-5907Z Recombinant Zebrafish HSPB8 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

HSPB8 involved in several pathways and played different roles in them. We selected most pathways HSPB8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPB8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

HSPB8 has several biochemical functions, for example, identical protein binding, protein binding, NOT protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPB8 itself. We selected most functions HSPB8 had, and list some proteins which have the same functions with HSPB8. You can find most of the proteins on our site.

Function Related Protein
identical protein bindingGLUL;TNN;CLDN7;MUL1A;CLDN17;PARK2;HAND1;PDGFB;MRAP2
protein bindingLCMT1;ANK2;MAPRE2;GNPDA2;SCARA5;PRPF4B;PRDX4;UBE2W;HNRNPD
NOT protein kinase activityTRIB2;TRIB1;STRADB;PXK;MLKL;STRADA;HSPB8

HSPB8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPB8 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPB8.

HSPB7; BAG3; HSPB2

Research Area

Related articles

Tao, X; Lu, W; et al. HspB8 expression in brain tissue after cerebral ischemic reperfusion and atorvastatin intervention in Sprague-Dawley rats. NEUROLOGICAL RESEARCH 37:229-237(2015).
Giorgetti, E; Rusmini, P; et al. Synergic prodegradative activity of Bicalutamide and trehalose on the mutant androgen receptor responsible for spinal and bulbar muscular atrophy. HUMAN MOLECULAR GENETICS 24:64-75(2015).
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