HSPB8 Protein


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Official Full Name heat shock 22kDa protein 8
Background The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.
Synonyms HSPB8; heat shock 22kDa protein 8; H11; HMN2; CMT2L; DHMN2; E2IG1; HMN2A; HSP22; heat shock protein beta-8; OTTHUMP00000239768; protein kinase H11; alpha-crystallin C chain; E2-induced gene 1 protein; heat shock 27kDa protein 8; small stress protein-like protein HSP22
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MBP
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HSPB8-1254H Recombinant Human Heat Shock 22kDa Protein 8 E.coli N/A
    Human HSPB8-165H Recombinant Human HSPB8 protein, His/MBP-tagged E.coli His/MBP
    Human HSPB8-2025H Recombinant Human Heat Shock 22kDa Protein 8, His-tagged E.coli His
    Human HSPB8-27526TH Recombinant Human HSPB8, His-tagged E.coli His
    Human HSPB8-29389TH Recombinant Human HSPB8 E.coli N/A
    Human HSPB8-5120H Recombinant Human HSPB8 Protein, GST-tagged Wheat Germ GST
    Mouse HSPB8-7919M Recombinant Mouse HSPB8 Protein Mammalian Cell His
    Rat HSPB8-2954R Recombinant Rat HSPB8 Protein Mammalian Cell His
    Rhesus Macaque HSPB8-2170R Recombinant Rhesus monkey HSPB8 Protein, His-tagged Mammalian Cell His
    Zebrafish HSPB8-5907Z Recombinant Zebrafish HSPB8 Mammalian Cell His
    Human HSPB8-5345HCL Recombinant Human HSPB8 293 Cell Lysate HEK293 N/A
    Human HSPB8-6700H Recombinant Human HSPB8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Hspb8-3457M Recombinant Mouse Hspb8 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    HSPB8 involved in several pathways and played different roles in them. We selected most pathways HSPB8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPB8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    HSPB8 has several biochemical functions, for example, identical protein binding, protein binding, NOT protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPB8 itself. We selected most functions HSPB8 had, and list some proteins which have the same functions with HSPB8. You can find most of the proteins on our site.

    Function Related Protein
    identical protein binding ITGA2B; PKD2L1; SNX16; NEFL; IGF2R; AGXT2L2; CASC3; SNRNP200; GAPDH; PON2
    protein binding DCLRE1C; PI4K2A; MAF; KRTAP13-3; BTRC; FARS2; NCKAP1; NHEJ1; ZNF32; PDE6G
    NOT protein kinase activity HSPB8; TRIB1; MLKL; TRIB2; STRADB; PXK; STRADA

    HSPB8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPB8 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPB8.

    HSPB7; BAG3; HSPB2

    Tao, X; Lu, W; et al. HspB8 expression in brain tissue after cerebral ischemic reperfusion and atorvastatin intervention in Sprague-Dawley rats. NEUROLOGICAL RESEARCH 37:229-237(2015).
    Giorgetti, E; Rusmini, P; et al. Synergic prodegradative activity of Bicalutamide and trehalose on the mutant androgen receptor responsible for spinal and bulbar muscular atrophy. HUMAN MOLECULAR GENETICS 24:64-75(2015).

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