Recombinant Human IL13RA1 Protein (Met1-Thr343), His-tagged, Biotinylated

Cat.No. : IL13RA1-457H
Product Overview : Recombinant Human IL13RA1 Protein (NP_001551.1) (Met1-Thr343) was produced by HEK293 Cells expression system. This protein was expressed with a C-terminal polyhistidine tag. The purified protein was biotinylated in vitro.
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Description : Interleukin 13 receptor, alpha 1, also known as IL13RA1/IL-13RA1 and CD213A1 (cluster of differentiation 213A1), is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. IL13RA1/IL-13RA1 serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. IL13RA1/IL-13RA1 binds with low affinity to interleukin-13 (IL13). This subunit together with IL4RA can form a functional receptor for IL13. IL13RA1/IL-13RA1 also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.
Source : HEK293
Species : Human
Tag : His
Predicted N Terminal : Gly 22
Form : Lyophilized from sterile Sterile PBS. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Molecular Mass : The recombinant IL13RA1 consists of 333 amino acids and predicts a molecular mass of 38.3 kDa.
Protein length : Met1-Thr343
Endotoxin : < 1.0 EU per μg protein as determined by the LAL method.
Purity : > 95 % as determined by SDS-PAGE.
Stability : Samples are stable for up to twelve months from date of receipt at -70 centigrade.
Storage : Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4ºC before opening to recover the entire contents.
Shipping : In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Gene Name : IL13RA1 interleukin 13 receptor, alpha 1 [ Homo sapiens ]
Official Symbol : IL13RA1
Synonyms : IL13RA1; CD213a1; CD213a1 antigen; IL 13Ra; NR4; CT19; IL-13RA1; IL-13R-alpha-1; CD213A1; IL-13Ra;
Gene ID : 3597
mRNA Refseq : NM_001560
Protein Refseq : NP_001551
MIM : 300119
UniProt ID : P78552

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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Q&As (10)

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What techniques determine IL13RA1 expression levels in different cell types? 12/05/2022

Techniques quantify IL13RA1 expression across diverse cell types.

What experimental strategies discern IL13RA1 isoforms and their functions? 10/04/2021

Strategies distinguish IL13RA1 isoforms and their roles.

Could you elaborate on the use of RNA-seq in profiling IL13RA1-regulated gene expression? 04/01/2021

RNA-seq profiles IL13RA1's influence on gene expression.

What are the advantages of using CRISPR/Cas9 to knockout IL13RA1 expression? 05/10/2020

CRISPR/Cas9 knockout clarifies IL13RA1's functional impact.

How do siRNA knockdown experiments validate IL13RA1's involvement in specific pathways? 03/08/2020

siRNA knockdown validates IL13RA1's pathway involvement.

Can you explain the role of co-immunoprecipitation in identifying IL13RA1 interaction partners? 01/17/2020

Co-immunoprecipitation identifies IL13RA1 interactors.

How does immunofluorescence microscopy visualize IL13RA1 localization within cells? 05/22/2019

Immunofluorescence microscopy visualizes intracellular IL13RA1 localization.

How does surface plasmon resonance (SPR) elucidate IL13RA1 binding kinetics? 10/08/2018

SPR elucidates IL13RA1 binding kinetics with precision.

Can you describe how surface biotinylation studies reveal IL13RA1 membrane localization? 09/25/2018

Surface biotinylation shows IL13RA1 membrane distribution.

How do fluorescence-based assays assess IL13RA1 internalization upon ligand binding? 06/19/2018

Fluorescence assays monitor IL13RA1 internalization upon ligand binding.

Customer Reviews (3)

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    High solubility. -


      Potent in anti-allergic assays. -


        Suitable for ELISA. -

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