Recombinant Human IL18R1 Protein, Fc-tagged
Cat.No. : | IL18R1-314H |
Product Overview : | Recombinant human IL18R1 protein with Fc tag was expressed in HEK293. |
- Specification
- Gene Information
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Description : | The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Source : | HEK293 |
Species : | Human |
Tag : | Fc |
Form : | Lyophilized |
Molecular Mass : | 62.4 kDa |
Protein Length : | 541 |
AA Sequence : | MNCRELPLTLWVLISVSTAESCTSR PHITVVEGEPFYLKHCSCSLAHEIE TTTKSWYKSSGSQEHVELNPRSSSR IALHDCVLEFWPVELNDTGSYFFQM KNYTQKWKLNVIRRNKHSCFTERQV TSKIVEVKKFFQITCENSYYQTLVN STSLYKNCKKLLLENNKNPTIKKNA EFEDQGYYSCVHFLHHNGKLFNITK TFNITIVEDRSNIVPVLLGPKLNHV AVELGKNVRLNCSALLNEEDVIYWM FGEENGSDPNIHEEKEMRIMTPEGK WHASKVLRIENIGESNLNVLYNCTV ASTGGTDTKSFILVRKADMADIPGH VFTRGMIIAVLILVAVVCLVTVCVI YRVDLVLFYRHLTRRDETLTDGKTY DAFVSYLKECRPENGEEHTFAVEIL PRVLEKHFGYKLCIFERDVVPGGAV VDEIHSLIEKSRRLIIVLSKSYMSN EVRYELESGLHEALVERKIKIILIE FTPVTDFTFLPQSLKLLKSHRVLKW KADKSLSYNSRFWKNLLYLMPAKTV KPGRDEPEVLPVLSES |
Purity : | > 98% |
Applications : | WB; ELISA; FACS; FC |
Stability : | This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
Storage : | At -20 centigrade. |
Concentration : | 1 mg/mL |
Storage Buffer : | PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
Reconstitution : | Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
Gene Name : | IL18R1 interleukin 18 receptor 1 [ Homo sapiens (human) ] |
Official Symbol : | IL18R1 |
Synonyms : | IL18R1; interleukin 18 receptor 1; interleukin-18 receptor 1; CD218a; IL 1Rrp; IL1RRP; IL-18R1; IL1R-rp; IL-18R-1; cytokine receptor; IL1 receptor-related protein; CD218 antigen-like family member A; IL18RA; CDw218a; IL-1Rrp; |
Gene ID : | 8809 |
mRNA Refseq : | NM_003855 |
Protein Refseq : | NP_003846 |
MIM : | 604494 |
UniProt ID : | Q13478 |
Products Types
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◆ Lysates | ||
IL18R1-837CCL | Recombinant Canine IL18R1 cell lysate | +Inquiry |
IL18R1-829RCL | Recombinant Rat IL18R1 cell lysate | +Inquiry |
IL18R1-2785MCL | Recombinant Mouse IL18R1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionCo-immunoprecipitation, co-receptor binding assays, and functional studies unveil the cooperative roles of IL18R1 and IL18RAP in signaling.
Fluorescence microscopy, confocal imaging, and super-resolution microscopy visualize IL18R1 dynamics and clustering upon IL18 stimulation.
Mass spectrometry, phosphorylation assays, and ubiquitination studies investigate IL18R1 post-translational modifications.
Disease model assessments, patient sample analyses, and pharmacological interventions explore IL18R1's involvement in diseases and therapeutic potential.
RT-qPCR, flow cytometry, and single-cell RNA sequencing assess IL18R1 expression across different cell types and physiological states.
Knockout models, siRNA-mediated knockdown, and CRISPR/Cas9 gene editing reveal the physiological roles of IL18R1 in vivo and in vitro.
Western blotting, ELISAs, and phosphoprotein analyses decipher IL18R1-mediated signaling cascades and cytokine production.
Site-directed mutagenesis, chimera studies, and domain swapping experiments dissect the functional contributions of IL18R1's domains.
X-ray crystallography, cryo-electron microscopy, and molecular dynamics simulations elucidate the structural basis of IL18R1-IL18 recognition and activation.
Surface plasmon resonance, bio-layer interferometry, and kinetic binding assays quantify IL18R1-IL18 interactions.
Customer Reviews (3)
Write a reviewLow endotoxin levels.
Good for flow cytometry.
Potent in Th1 activation.
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