Active Recombinant Human IL1B Protein, Pre-aliquoted
Cat.No. : | IL1B-05H |
Product Overview : | Recombinant Human IL1B Protein, Ala117 - Ser269, was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. |
Source : | E. coli |
Species : | Human |
Bio-activity : | Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. The ED50 for this effect is <12 pg/mL. |
Molecular Mass : | Predicted Molecular Mass:17 kDa |
Protein length : | Ala117-Ser269 |
N-terminal Sequence Analysis : | Ala117 & Pro118 |
Endotoxin : | < 0.10 EU/μg of the protein by the LAL method. |
Purity : | > 97% by SDS-PAGE under reducing conditions and visualized by silver stain. |
Stability : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. • 6 months from date of receipt at room temperature. • 12 months from date of receipt at 2-8 centigrade as supplied. • 1 month at 2-8 centigrade under sterile conditions after reconstitution. • 3 months at -20 to -80 centigrade under sterile conditions after reconstitution. |
Reconstitution : | For a stock solution, reconstitute at 25 μg/mL in sterile PBS, or simply roll Pre-aliquoted directly into cell culture medium for immediate use. |
Shipping : | The product is shipped at ambient temperature. |
Gene Name : | IL1B interleukin 1 beta [ Homo sapiens (human) ] |
Official Symbol : | IL1B |
Synonyms : | IL1B; interleukin 1 beta; IL-1; IL1F2; IL1beta; IL1-BETA; interleukin-1 beta; IL-1 beta; catabolin; interleukin 1beta; preinterleukin 1 beta; pro-interleukin-1-beta |
Gene ID : | 3553 |
mRNA Refseq : | NM_000576 |
Protein Refseq : | NP_000567 |
MIM : | 147720 |
UniProt ID : | P01584 |
Products Types
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◆ Lysates | ||
IL1B-853HCL | Recombinant Human IL1B cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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