Recombinant Human IL21R Protein, C-His-tagged

Cat.No. : IL21R-109H
Product Overview : Recombinant Human IL21R Protein with C-His tag was expressed in E. coli.
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Description : The IL-21 receptor (also designated IL-21R, NILR or novel interleukin receptor) is a type I cytokine receptor that forms a complex with the cytokine receptor γ chain, γc and mediates IL-21 signaling. IL-21R is present on the surface of natural killer, B and T cell populations with high levels in spleen and thymus. IL-21 and IL-21R influence lymphoid proliferation and early lymphoid development in the transition between innate and adaptive immunity. Tumor necrosis factor (TNF) upregulates IL-21R, and combinations of TNF and IL-21 can have synergistic effects on myeloma cell proliferation through pathways involving phosphorylation of JAK1, Stat3 and Erk1/2. The human IL-21R gene maps to chromosome 16p12.1 and encodes a 538 amino acid protein that is closely related to human IL2RB and shares 62% sequence identity to mouse Il21r.
Source : E. coli
Species : Human
Tag : C-His
Molecular Mass : ~23 kDa
AA Sequence : CPDLVCYTDYLQTVICILEMWNLHP STLTLTWQDQYEELKDEATSCSLHR SAHNATHATYTCHMDVFHFMADDIF SVNITDQSGNYSQECGSFLLAESIK PAPPFNVTVTFSGQYNISWRSDYED PAFYMLKGKLQYELQYRNRGDPWAV SPRRKLISVDSRSVSLLPLEFRKDS SYELQVRAGPMPGSSYQGTWSEWSD PVIFQTQSEELKE
Purity : Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).
Notes : For research use only, not for use in diagnostic procedure.
Storage : Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles.
Concentration : ≥0.5 mg/mL
Storage Buffer : PBS, 4M Urea, pH7.4
Gene Name : IL21R interleukin 21 receptor [ Homo sapiens (human) ]
Official Symbol : IL21R
Synonyms : IL21R; interleukin 21 receptor; interleukin-21 receptor; CD360; IL-21R; IL-21 receptor; novel interleukin receptor; NILR; MGC10967;
Gene ID : 50615
mRNA Refseq : NM_021798
Protein Refseq : NP_068570
MIM : 605383
UniProt ID : Q9HBE5

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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