The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the
IL21R involved in several pathways and played different roles in them. We selected most pathways IL21R participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with IL21R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
IL21R has several biochemical functions, for example, interleukin-21 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL21R itself. We selected most functions IL21R had, and list some proteins which have the same functions with IL21R. You can find most of the proteins on our site.
interleukin-21 receptor activity
IL21R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL21R here. Most of them are supplied by our site. Hope this information will be useful for your research of IL21R.
Liao, W; Spolski, R; et al. Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:3508-3513(2014).
Berglund, LJ; Avery, DT; et al. IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts. BLOOD 122:3940-3950(2013).